{"title":"含四苯乙烯π-肽的序列依赖性聚集诱导发射特性","authors":"Runlai Wang, and , John D. Tovar*, ","doi":"10.1021/acs.macromol.5c00976","DOIUrl":null,"url":null,"abstract":"<p >Four pH-responsive π-peptide macromolecules embedded with the known Aggregation Induced Emission chromophore (AIE-gen) tetraphenylethene (TPE) were examined to explore how peptide side chain composition influenced the nature of the AIE under aqueous conditions. These molecules were readily synthesized via standard solid-phase peptide synthesis (SPPS) followed by on-resin 4-fold conjugation with a functionalized TPE. The specific outcomes of the AIE upon π-peptide pH-driven assembly, as influenced by the nature of the peptide sequence, were characterized by ultraviolet–visible (UV–vis), photoluminescence (PL) and circular dichroism (CD) spectroscopies in aqueous media, along with transmission electron microscopy (TEM) to visualize nanomaterial morphologies resulting from the pH-triggered aggregation. Peptide side chains play a critical role in regulating emission in aggregated states. This study offers a new strategy for designing and modulating fluorescent molecules in aggregated states.</p>","PeriodicalId":51,"journal":{"name":"Macromolecules","volume":"58 15","pages":"8352–8359"},"PeriodicalIF":5.2000,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Sequence-Dependent Aggregation-Induced-Emission Characteristics of Tetraphenylethene-Containing π-Peptides\",\"authors\":\"Runlai Wang, and , John D. Tovar*, \",\"doi\":\"10.1021/acs.macromol.5c00976\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >Four pH-responsive π-peptide macromolecules embedded with the known Aggregation Induced Emission chromophore (AIE-gen) tetraphenylethene (TPE) were examined to explore how peptide side chain composition influenced the nature of the AIE under aqueous conditions. These molecules were readily synthesized via standard solid-phase peptide synthesis (SPPS) followed by on-resin 4-fold conjugation with a functionalized TPE. The specific outcomes of the AIE upon π-peptide pH-driven assembly, as influenced by the nature of the peptide sequence, were characterized by ultraviolet–visible (UV–vis), photoluminescence (PL) and circular dichroism (CD) spectroscopies in aqueous media, along with transmission electron microscopy (TEM) to visualize nanomaterial morphologies resulting from the pH-triggered aggregation. Peptide side chains play a critical role in regulating emission in aggregated states. This study offers a new strategy for designing and modulating fluorescent molecules in aggregated states.</p>\",\"PeriodicalId\":51,\"journal\":{\"name\":\"Macromolecules\",\"volume\":\"58 15\",\"pages\":\"8352–8359\"},\"PeriodicalIF\":5.2000,\"publicationDate\":\"2025-07-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Macromolecules\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://pubs.acs.org/doi/10.1021/acs.macromol.5c00976\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"POLYMER SCIENCE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Macromolecules","FirstCategoryId":"92","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acs.macromol.5c00976","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}
Sequence-Dependent Aggregation-Induced-Emission Characteristics of Tetraphenylethene-Containing π-Peptides
Four pH-responsive π-peptide macromolecules embedded with the known Aggregation Induced Emission chromophore (AIE-gen) tetraphenylethene (TPE) were examined to explore how peptide side chain composition influenced the nature of the AIE under aqueous conditions. These molecules were readily synthesized via standard solid-phase peptide synthesis (SPPS) followed by on-resin 4-fold conjugation with a functionalized TPE. The specific outcomes of the AIE upon π-peptide pH-driven assembly, as influenced by the nature of the peptide sequence, were characterized by ultraviolet–visible (UV–vis), photoluminescence (PL) and circular dichroism (CD) spectroscopies in aqueous media, along with transmission electron microscopy (TEM) to visualize nanomaterial morphologies resulting from the pH-triggered aggregation. Peptide side chains play a critical role in regulating emission in aggregated states. This study offers a new strategy for designing and modulating fluorescent molecules in aggregated states.
期刊介绍：
Macromolecules publishes original, fundamental, and impactful research on all aspects of polymer science. Topics of interest include synthesis (e.g., controlled polymerizations, polymerization catalysis, post polymerization modification, new monomer structures and polymer architectures, and polymerization mechanisms/kinetics analysis); phase behavior, thermodynamics, dynamic, and ordering/disordering phenomena (e.g., self-assembly, gelation, crystallization, solution/melt/solid-state characteristics); structure and properties (e.g., mechanical and rheological properties, surface/interfacial characteristics, electronic and transport properties); new state of the art characterization (e.g., spectroscopy, scattering, microscopy, rheology), simulation (e.g., Monte Carlo, molecular dynamics, multi-scale/coarse-grained modeling), and theoretical methods. Renewable/sustainable polymers, polymer networks, responsive polymers, electro-, magneto- and opto-active macromolecules, inorganic polymers, charge-transporting polymers (ion-containing, semiconducting, and conducting), nanostructured polymers, and polymer composites are also of interest. Typical papers published in Macromolecules showcase important and innovative concepts, experimental methods/observations, and theoretical/computational approaches that demonstrate a fundamental advance in the understanding of polymers.
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