呼吸道合胞病毒抑制剂的研究进展。

IF 2.2 4区医学 Q3 CHEMISTRY, MEDICINAL

Bioorganic & Medicinal Chemistry Letters Pub Date : 2025-08-07 DOI:10.1016/j.bmcl.2025.130365

Zhongling Shi , Anchao Ge , Xin Li , Jinyuan Wu , Zhao Wang , Dongwei Kang , Xinyong Liu

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引用次数: 0

摘要

呼吸道合胞病毒（RSV）仍然是婴儿和老年人严重下呼吸道感染的主要原因，尽管缺乏治疗RSV感染的特异性治疗药物。本文综述了近年来RSV药物发现的结构进展，特别是病毒融合(F)蛋白和RNA聚合酶抑制剂的共晶结构。通过强调它们在合理的基于结构的药物设计中的重要性，我们希望通过基于结构的方法为下一代RSV治疗药物的开发提供有价值的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Recent advances of the respiratory syncytial virus inhibitors

Respiratory syncytial virus (RSV) remains a leading cause of severe lower respiratory tract infections in infants and the elderly, despite the lack of specific therapeutic drugs for treating RSV infection. This review summarizes recent structural advances in RSV drug discovery, particularly the co-crystal structures of the viral fusion (F) protein and RNA polymerase with inhibitors. By highlighting their significance in rational structure-based drug design, we hope to provide valuable insights for the development of next-generation RSV therapeutics via structure-based approaches.

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来源期刊

Bioorganic & Medicinal Chemistry Letters 医学-医药化学

CiteScore

5.70

自引率

3.70%

发文量

463

审稿时长

27 days

期刊介绍： Bioorganic & Medicinal Chemistry Letters presents preliminary experimental or theoretical research results of outstanding significance and timeliness on all aspects of science at the interface of chemistry and biology and on major advances in drug design and development. The journal publishes articles in the form of communications reporting experimental or theoretical results of special interest, and strives to provide maximum dissemination to a large, international audience.