低成本手性助剂辅助羟基肟酸衍生物与甘氨酸衍生物的远端不对称C(sp3) -H烷基化反应

IF 4.2 3区化学 Q2 CHEMISTRY, PHYSICAL

Catalysis Science & Technology Pub Date : 2025-07-08 DOI:10.1039/d5cy00604j

Zhongzhen Yang , Li Li , Jian Chen , Jinyu Hou , Hongying Fan , Xue Zhang , Guanghui Lv , Yong Wu

{"title":"低成本手性助剂辅助羟基肟酸衍生物与甘氨酸衍生物的远端不对称C(sp3) -H烷基化反应","authors":"Zhongzhen Yang , Li Li , Jian Chen , Jinyu Hou , Hongying Fan , Xue Zhang , Guanghui Lv , Yong Wu","doi":"10.1039/d5cy00604j","DOIUrl":null,"url":null,"abstract":"<div><div>Visible-light-mediated commercially available and cost-effective chiral auxiliary-assisted radical–radical cross-coupling for the preparation of noncanonical chiral amino acids under base- and metal-free conditions has been reported. The reaction featured a broad substrate scope and excellent enantioselectivity. Besides, the products can be converted to biologically important chiral β-amino alcohols under simple procedures.</div></div>","PeriodicalId":66,"journal":{"name":"Catalysis Science & Technology","volume":"15 16","pages":"Pages 4866-4871"},"PeriodicalIF":4.2000,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cost-effective chiral auxiliary-assisted remote asymmetric C(sp3)–H alkylation of hydroxamic acid derivatives with glycine derivatives†\",\"authors\":\"Zhongzhen Yang , Li Li , Jian Chen , Jinyu Hou , Hongying Fan , Xue Zhang , Guanghui Lv , Yong Wu\",\"doi\":\"10.1039/d5cy00604j\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Visible-light-mediated commercially available and cost-effective chiral auxiliary-assisted radical–radical cross-coupling for the preparation of noncanonical chiral amino acids under base- and metal-free conditions has been reported. The reaction featured a broad substrate scope and excellent enantioselectivity. Besides, the products can be converted to biologically important chiral β-amino alcohols under simple procedures.</div></div>\",\"PeriodicalId\":66,\"journal\":{\"name\":\"Catalysis Science & Technology\",\"volume\":\"15 16\",\"pages\":\"Pages 4866-4871\"},\"PeriodicalIF\":4.2000,\"publicationDate\":\"2025-07-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Catalysis Science & Technology\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/org/science/article/pii/S2044475325003028\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Catalysis Science & Technology","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S2044475325003028","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}

引用次数: 0

摘要

在无碱和无金属的条件下，用可见光介导的、商业化的、具有成本效益的手性辅助自由基-自由基交叉偶联制备了非典型手性氨基酸。该反应的底物范围广，对映体选择性好。此外，产物可以在简单的程序下转化为具有重要生物学意义的手性β-氨基醇。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Cost-effective chiral auxiliary-assisted remote asymmetric C(sp3)–H alkylation of hydroxamic acid derivatives with glycine derivatives†

查看原文本刊更多论文

Cost-effective chiral auxiliary-assisted remote asymmetric C(sp3)–H alkylation of hydroxamic acid derivatives with glycine derivatives†

Visible-light-mediated commercially available and cost-effective chiral auxiliary-assisted radical–radical cross-coupling for the preparation of noncanonical chiral amino acids under base- and metal-free conditions has been reported. The reaction featured a broad substrate scope and excellent enantioselectivity. Besides, the products can be converted to biologically important chiral β-amino alcohols under simple procedures.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Catalysis Science & Technology CHEMISTRY, PHYSICAL-

CiteScore

8.70

自引率

6.00%

发文量

587

审稿时长

1.5 months

期刊介绍： A multidisciplinary journal focusing on cutting edge research across all fundamental science and technological aspects of catalysis. Editor-in-chief: Bert Weckhuysen Impact factor: 5.0 Time to first decision (peer reviewed only): 31 days