五环三萜山林酸促进头发生长与米诺地尔相当：对纤毛活性潜在参与的新见解

IF 3.7 Q1 CHEMISTRY, MEDICINAL

ACS Pharmacology and Translational Science Pub Date : 2025-07-24 DOI:10.1021/acsptsci.5c00189

Aprill Kee Oliva Mizushima, Meryem Bouhoute, Meriem Bejaoui, Farhana Ferdousi, Mitsutoshi Nakajima and Hiroko Isoda*,

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引用次数: 0

摘要

山茱萸酸是橄榄提取物中的一种五环三萜成分。在这项研究中，我们阐明了山茱萸酸对头发生长的影响，并探讨了其潜在的机制。局部应用山楂酸刺激小鼠毛发生长，与米诺地尔相当，其中观察到加速生长原诱导。此外，山楂酸治疗导致CTNNB1和VEGF蛋白水平升高，并上调毛原基因（包括CTNNB1、ALPL和FGF1） mRNA表达。此外，参与头发生长的关键途径和生物过程被激活，如Wnt、Notch、MAPK和血管生成。有趣的是，一种促进纤毛生长的基因Iqcb1被发现被山楂酸上调，这使我们探索了头发生长和纤毛活性之间的潜在联系。值得注意的是，抑制纤毛活性导致CTNNB1下调。总之，我们的研究表明，山楂酸通过Wnt/β-catenin途径刺激头发生长，并引入了一个可能的机制，涉及纤毛基因活性。

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Pentacyclic Triterpenoid Maslinic Acid Promotes Hair Growth Comparable to Minoxidil: A New Insight on the Potential Involvement of Cilia Activity

Maslinic acid is a pentacyclic triterpene component of olive extracts. In this study, we elucidated the effects of maslinic acid on hair growth and explored its underlying mechanisms. The topical application of maslinic acid stimulates hair growth in mice comparable to minoxidil, where an acceleration in anagen induction was observed. Moreover, treatment with maslinic acid led to increased protein levels of CTNNB1 and VEGF, and upregulated the mRNA expression of trichogenic genes, including CTNNB1, ALPL, and FGF1. Additionally, crucial pathways and biological processes involved in hair growth were activated such the Wnt, Notch, MAPK, and angiogenesis. Interestingly, Iqcb1, a ciliogenesis-promoting gene, was found to be upregulated by maslinic acid, leading us to explore the potential link between hair growth and cilia activity. Notably, inhibiting cilia activity resulted in the downregulation of CTNNB1. Altogether, our study suggests that maslinic acid stimulates hair growth through the Wnt/β-catenin pathway and introduces a possible mechanism involving ciliary gene activity.

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来源期刊

ACS Pharmacology and Translational Science Medicine-Pharmacology (medical)

CiteScore

10.00

自引率

3.30%

发文量

133

期刊介绍： ACS Pharmacology & Translational Science publishes high quality, innovative, and impactful research across the broad spectrum of biological sciences, covering basic and molecular sciences through to translational preclinical studies. Clinical studies that address novel mechanisms of action, and methodological papers that provide innovation, and advance translation, will also be considered. We give priority to studies that fully integrate basic pharmacological and/or biochemical findings into physiological processes that have translational potential in a broad range of biomedical disciplines. Therefore, studies that employ a complementary blend of in vitro and in vivo systems are of particular interest to the journal. Nonetheless, all innovative and impactful research that has an articulated translational relevance will be considered. ACS Pharmacology & Translational Science does not publish research on biological extracts that have unknown concentration or unknown chemical composition. Authors are encouraged to use the pre-submission inquiry mechanism to ensure relevance and appropriateness of research.