Wenli Zhou, Xinming Jing, Ruyi Hang, Zheng Liu, Lin Cao, Mengxia Li
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Base excision repair in human cancer: Emerging diagnostic and therapeutic target.
DNA base excision repair (BER) is an evolutionarily conserved and essential DNA repair mechanism that acts as the major surveillance system for base lesions caused by endogenous and exogenous attacks. Therefore, BER is required for maintaining genomic stability under both physiological and pathological conditions. In this paper, we provide a brief review of the germline and somatic alterations of BER in cancer, with a particular focus on the core enzyme apurinic/ apyrimidinic endonuclease 1 (APE1), encoded by APEX1, and the mechanistic relationship to the development and treatment of cancer. Additionally, the review discusses the latest advances in BER-associated detection technologies and their potential clinical applications, underscoring the therapeutic potential of targeting BER for cancer prevention and intervention.
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