与天冬酰胺酶pegol相关的严重高甘油三酯血症。

IF 2.2 4区医学 Q3 HEMATOLOGY

Leukemia & Lymphoma Pub Date : 2025-08-09 DOI:10.1080/10428194.2025.2543578

Alexis K Kuhn, Madeleine O'Keefe, Mira Kohorst, Jessica Kalmes, Paul Galardy, Ashley Walter, John Guggenberger, Mostafa Salama, Siobhan Pittock, Catherine Martin

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引用次数: 0

摘要

天冬酰胺酶pegol是目前美国儿童、青少年和年龄在1个月至21.5岁的年轻人可以使用的唯一聚乙二醇化天冬酰胺酶产品。尽管越来越多的人认识到其真实世界的毒性，高甘油三酯血症还没有深入描述与天冬酰胺酶pegol。在此，我们描述了我们的临床观察，六名患者在暴露于天冬酰胺酶pegol后经历了显著的高甘油三酯血症，在一些情况下需要重症监护。潜在的混杂风险因素和管理策略，这种假定的毒性进行了探讨。

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Severe hypertriglyceridemia associated with calaspargase pegol.

Calaspargase pegol is currently the only pegylated asparaginase product accessible to children, adolescents, and young adults aged 1 month to 21.5 years in the United States. Despite a growing recognition of its real-world toxicity profile, hypertriglyceridemia has not yet been described in depth with calaspargase pegol. Herein we describe our clinical observations of six patients who experienced significant hypertriglyceridemia following exposure to calaspargase pegol, warranting intensive care in several cases. Potential confounding risk factors and management strategies of this presumed toxicity are explored.

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来源期刊

Leukemia & Lymphoma 医学-血液学

CiteScore

4.10

自引率

3.80%

发文量

384

审稿时长

1.8 months

期刊介绍： Leukemia & Lymphoma in its fourth decade continues to provide an international forum for publication of high quality clinical, translational, and basic science research, and original observations relating to all aspects of hematological malignancies. The scope ranges from clinical and clinico-pathological investigations to fundamental research in disease biology, mechanisms of action of novel agents, development of combination chemotherapy, pharmacology and pharmacogenomics as well as ethics and epidemiology. Submissions of unique clinical observations or confirmatory studies are considered and published as Letters to the Editor