Maheshwari S等人关于“印度队列退行性颈椎病中CALM1多态性”的致编辑信（Eur spine J [2025]: doi.org/10.1007/s00586-025-09090-7）。

IF 2.7 3区医学 Q2 CLINICAL NEUROLOGY

European Spine Journal Pub Date : 2025-10-01 Epub Date: 2025-08-09 DOI:10.1007/s00586-025-09261-6

Tharun Teja Aduri, Sharath Raj

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引用次数: 0

摘要

我们赞赏Maheshwari等人在印度队列中探索退行性颈椎病（DCM）中CALM1多态性的努力。虽然这项研究提供了有价值的见解，但我们尊重地强调某些方法上的关注，特别是关于统计解释、对照组异质性和组间年龄差异。此外，表明计算良性变异的致病性的解释可能受益于额外的功能验证。我们相信，在未来的研究中解决这些问题将增强DCM基因研究的稳健性和翻译相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Letter to the editor concerning "CALM1 polymorphism in degenerative cervical myelopathy of the Indian cohort" by Maheshwari S et al. (Eur spine J [2025]: doi.org/10.1007/s00586-025-09090-7).

We appreciate the efforts of Maheshwari et al. in exploring CALM1 polymorphisms in degenerative cervical myelopathy (DCM) within an Indian cohort. While the study offers valuable insights, we respectfully highlight certain methodological concerns-particularly regarding statistical interpretation, control group heterogeneity, and age differences between groups. Furthermore, interpretations suggesting pathogenicity for a computationally benign variant may benefit from additional functional validation. We believe that addressing these aspects in future studies will enhance the robustness and translational relevance of genetic research in DCM.

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来源期刊

European Spine Journal 医学-临床神经学

CiteScore

4.80

自引率

10.70%

发文量

373

审稿时长

2-4 weeks

期刊介绍： "European Spine Journal" is a publication founded in response to the increasing trend toward specialization in spinal surgery and spinal pathology in general. The Journal is devoted to all spine related disciplines, including functional and surgical anatomy of the spine, biomechanics and pathophysiology, diagnostic procedures, and neurology, surgery and outcomes. The aim of "European Spine Journal" is to support the further development of highly innovative spine treatments including but not restricted to surgery and to provide an integrated and balanced view of diagnostic, research and treatment procedures as well as outcomes that will enhance effective collaboration among specialists worldwide. The “European Spine Journal” also participates in education by means of videos, interactive meetings and the endorsement of educative efforts. Official publication of EUROSPINE, The Spine Society of Europe