肢端黄斑性黑色素瘤的治疗和生存差异:国家癌症数据库的多变量分析。

IF 1.9 4区 医学 Q3 DERMATOLOGY
Rachel C Chang, Elise K Brunsgaard, David C Reid
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引用次数: 0

摘要

本回顾性队列研究评估了不同保险类型、种族群体和社会经济地位(SES)在肢端黄斑性黑色素瘤(ALM)中的差异。我们分析了2016-2020年国家癌症数据库中诊断为ALM的成年人。Cox比例风险模型评估了人口统计学和临床变量与alm特异性生存率之间的关系。Kaplan-Meier曲线分析1、3、5年生存率。共发现3446例ALM患者。未参保的患者出现晚期癌症,经历更长的治疗时间,更有可能进行大截肢与私人参保的患者相比(P
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Treatment and survival disparities in acral lentiginous melanoma: a National Cancer Database multivariate analysis.

This retrospective cohort study evaluated disparities across insurance types, racial groups, and socioeconomic status (SES) in acral lentiginous melanoma (ALM). We analyzed adults diagnosed with ALM in the National Cancer Database from 2016-2020. Cox proportional hazards model assessed associations between demographic and clinical variables with ALM-specific survival. Kaplan-Meier curves analyzed 1-, 3-, and 5-year survival. A total of 3446 patients with ALM were identified. Uninsured patients presented with advanced-stage cancers, experienced longer time to treatment, and were more likely to undergo major amputations compared with privately insured patients (P < 0.001). Survival analysis indicated lower probabilities for uninsured patients at 1, 3, and 5 years, although the differences did not reach statistical significance. Black patients were more likely uninsured, had higher Charlson-Deyo comorbidity scores, resided in areas of lower income and education, experienced longer time to treatment (P < 0.001), and had significantly lower survival at 3 and 5 years compared with White patients (P < 0.01). Patients in SES Q1 traveled further for care, had longer time to treatment, were less likely to be treated with Mohs surgery (P < 0.001), and had worse survival at 1, 3, and 5 years compared with patients in SES Q4 (P < 0.001). In conclusion, significant disparities in disease presentation, access to care, and health outcomes in patients with ALM exist based on insurance status, race, and SES, emphasizing the need for targeted interventions to enhance early diagnosis and equitable treatment.

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来源期刊
Melanoma Research
Melanoma Research 医学-皮肤病学
CiteScore
3.40
自引率
4.50%
发文量
139
审稿时长
6-12 weeks
期刊介绍: ​​​​​​Melanoma Research is a well established international forum for the dissemination of new findings relating to melanoma. The aim of the Journal is to promote the level of informational exchange between those engaged in the field. Melanoma Research aims to encourage an informed and balanced view of experimental and clinical research and extend and stimulate communication and exchange of knowledge between investigators with differing areas of expertise. This will foster the development of translational research. The reporting of new clinical results and the effect and toxicity of new therapeutic agents and immunotherapy will be given emphasis by rapid publication of Short Communications. ​Thus, Melanoma Research seeks to present a coherent and up-to-date account of all aspects of investigations pertinent to melanoma. Consequently the scope of the Journal is broad, embracing the entire range of studies from fundamental and applied research in such subject areas as genetics, molecular biology, biochemistry, cell biology, photobiology, pathology, immunology, and advances in clinical oncology influencing the prevention, diagnosis and treatment of melanoma.
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