{"title":"Serpine1与缺血性心力衰竭肥胖悖论的关系","authors":"Xiaoqiu Zhu, Junyan Hua","doi":"10.18502/ijph.v54i7.19158","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Extreme obesity pathology is with a risk factor for heart failure (HF), whereas the obesity paradox in HF shows that obese subjects had a good prognosis. The mechanism underlying the obesity paradox in HF prognosis is unclear till now. We aimed to provide evidence for the molecular mechanisms of the obesity paradox in HF.</p><p><strong>Methods: </strong>Differentially expressed genes (DEGs) in ischemic HF samples were identified in the GSE57338 and GSE5406 datasets. Weighted gene co-expression network analysis (WGCNA) modules and a protein-protein interaction network (PPI) were constructed. HF-associated DEGs and pathways were screened in the Comparative Toxicogenomics Database (CTD). The expression of hub genes in adipose tissues from obese patients and LV samples from HF patients were validated in microarray datasets.</p><p><strong>Results: </strong>Three HF-associated WGCNA modules were identified and DEGs were associated with the 'hsa04115: <i>p53</i> signaling pathway'. <i>SERPINE1</i> was the only common gene between DEGs and HF-associated genes in the CTD database. The <i>SERPINE1</i> gene was downregulated in the white adipose tissues compared with brown adipose tissues (<i>P</i> = 3.90e-03) and was upregulated in the omental adipose tissues from obese patients compared with lean subjects (<i>P</i> = 3.85e-02).</p><p><strong>Conclusion: </strong>The downregulation of <i>SERPINE1</i> expression might be responsible for the obesity paradox in HF via interacting with <i>ESR1</i>.</p>","PeriodicalId":14685,"journal":{"name":"Iranian Journal of Public Health","volume":"54 7","pages":"1516-1529"},"PeriodicalIF":1.6000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12325863/pdf/","citationCount":"0","resultStr":"{\"title\":\"Association of the Serpine1 with the Obesity Paradox in Ischemic Heart Failure.\",\"authors\":\"Xiaoqiu Zhu, Junyan Hua\",\"doi\":\"10.18502/ijph.v54i7.19158\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Extreme obesity pathology is with a risk factor for heart failure (HF), whereas the obesity paradox in HF shows that obese subjects had a good prognosis. The mechanism underlying the obesity paradox in HF prognosis is unclear till now. We aimed to provide evidence for the molecular mechanisms of the obesity paradox in HF.</p><p><strong>Methods: </strong>Differentially expressed genes (DEGs) in ischemic HF samples were identified in the GSE57338 and GSE5406 datasets. Weighted gene co-expression network analysis (WGCNA) modules and a protein-protein interaction network (PPI) were constructed. HF-associated DEGs and pathways were screened in the Comparative Toxicogenomics Database (CTD). The expression of hub genes in adipose tissues from obese patients and LV samples from HF patients were validated in microarray datasets.</p><p><strong>Results: </strong>Three HF-associated WGCNA modules were identified and DEGs were associated with the 'hsa04115: <i>p53</i> signaling pathway'. <i>SERPINE1</i> was the only common gene between DEGs and HF-associated genes in the CTD database. The <i>SERPINE1</i> gene was downregulated in the white adipose tissues compared with brown adipose tissues (<i>P</i> = 3.90e-03) and was upregulated in the omental adipose tissues from obese patients compared with lean subjects (<i>P</i> = 3.85e-02).</p><p><strong>Conclusion: </strong>The downregulation of <i>SERPINE1</i> expression might be responsible for the obesity paradox in HF via interacting with <i>ESR1</i>.</p>\",\"PeriodicalId\":14685,\"journal\":{\"name\":\"Iranian Journal of Public Health\",\"volume\":\"54 7\",\"pages\":\"1516-1529\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12325863/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Iranian Journal of Public Health\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.18502/ijph.v54i7.19158\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Iranian Journal of Public Health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.18502/ijph.v54i7.19158","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
Association of the Serpine1 with the Obesity Paradox in Ischemic Heart Failure.
Background: Extreme obesity pathology is with a risk factor for heart failure (HF), whereas the obesity paradox in HF shows that obese subjects had a good prognosis. The mechanism underlying the obesity paradox in HF prognosis is unclear till now. We aimed to provide evidence for the molecular mechanisms of the obesity paradox in HF.
Methods: Differentially expressed genes (DEGs) in ischemic HF samples were identified in the GSE57338 and GSE5406 datasets. Weighted gene co-expression network analysis (WGCNA) modules and a protein-protein interaction network (PPI) were constructed. HF-associated DEGs and pathways were screened in the Comparative Toxicogenomics Database (CTD). The expression of hub genes in adipose tissues from obese patients and LV samples from HF patients were validated in microarray datasets.
Results: Three HF-associated WGCNA modules were identified and DEGs were associated with the 'hsa04115: p53 signaling pathway'. SERPINE1 was the only common gene between DEGs and HF-associated genes in the CTD database. The SERPINE1 gene was downregulated in the white adipose tissues compared with brown adipose tissues (P = 3.90e-03) and was upregulated in the omental adipose tissues from obese patients compared with lean subjects (P = 3.85e-02).
Conclusion: The downregulation of SERPINE1 expression might be responsible for the obesity paradox in HF via interacting with ESR1.
期刊介绍：
Iranian Journal of Public Health has been continuously published since 1971, as the only Journal in all health domains, with wide distribution (including WHO in Geneva and Cairo) in two languages (English and Persian). From 2001 issue, the Journal is published only in English language. During the last 41 years more than 2000 scientific research papers, results of health activities, surveys and services, have been published in this Journal. To meet the increasing demand of respected researchers, as of January 2012, the Journal is published monthly. I wish this will assist to promote the level of global knowledge. The main topics that the Journal would welcome are: Bioethics, Disaster and Health, Entomology, Epidemiology, Health and Environment, Health Economics, Health Services, Immunology, Medical Genetics, Mental Health, Microbiology, Nutrition and Food Safety, Occupational Health, Oral Health. We would be very delighted to receive your Original papers, Review Articles, Short communications, Case reports and Scientific Letters to the Editor on the above mentioned research areas.
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