尼日利亚围生期心肌病患者血管紧张素转换酶基因多态性。

IF 0.7 4区医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiovascular Journal of Africa Pub Date : 2025-06-30 Epub Date: 2025-06-20 DOI:10.5830/CVJA-2025-010

Fatima Muhammed Bashir, Isa Abubakar Aliyu, Imam Malik Kabir, Shaheeda Labaran Farouk, Hadiza Sa'idu, Kamilu Musa Karaye

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引用次数: 0

摘要

简介：本研究旨在确定血管紧张素转换酶（ACE）基因I/D多态性与尼日利亚卡诺围产期心肌病（PPCM）的关系。方法：在尼日利亚卡诺Aminu Kano教学医院连续招募50例PPCM患者，并与50例表面健康的产褥期男性患者作为对照。获得书面知情同意后，采用聚合酶链反应法进行ACE基因分型。结果：PPCM患者与对照组相比，ACE ID和DD基因型患病率无显著差异(44.0% vs 36.0%, p = 0.414；36.0%对40.0%,p = 0.680)。重要的是，ACE基因多态性与PPCM之间的相关性无统计学意义(优势比：1.46,95%可信区间：0.52-4.17；P = 0.477)。结论：ACE基因I/D多态性在PPCM患者和对照组之间的患病率无显著差异。在尼日利亚卡诺，ACE基因I/D多态性与PPCM无关。

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Angiotensin converting enzyme gene polymorphism in Nigerians with peripartum cardiomyopathy.

Introduction: This study aimed to determine the association between angiotensin converting enzyme (ACE) gene I/D polymorphism and peripartum cardiomyopathy (PPCM) in Kano, Nigeria.

Methods: 50 PPCM patients were consecutively recruited and compared with 50 apparently healthy puerperal wo men as controls, in Aminu Kano Teaching Hospital, Kano, Nigeria. ACE genotyping was done by polymerase chain reaction method, after obtaining written informed consent.

Results: There was no significant difference in the prevalence of ACE ID and DD genotypes in the PPCM patients versus controls (44.0% vs 36.0%, p = 0.414; and 36.0% versus 40.0%, p = 0.680, respectively). Importantly, the association between ACE gene polymorphism and PPCM was not statistically significant (odds ratio: 1.46, 95% confidence interval: 0.52-4.17; p = 0.477).

Conclusions: The prevalence of ACE gene I/D polymorphism was not significantly different between PPCM patients and controls. ACE gene I/D polymorphism was not associated with PPCM in Kano, Nigeria.

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来源期刊

Cardiovascular Journal of Africa CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

1.30

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： The Cardiovascular Journal of Africa (CVJA) is an international peer-reviewed journal that keeps cardiologists up to date with advances in the diagnosis and treatment of cardiovascular disease. Topics covered include coronary disease, electrophysiology, valve disease, imaging techniques, congenital heart disease (fetal, paediatric and adult), heart failure, surgery, and basic science.