{"title":"葡萄糖依赖性胰岛素多肽受体多态性rs3848460和rs3895874与妊娠期糖尿病风险的关系","authors":"Gyan Watson Ray, Hengli Zhang, Taotao Shao, Taili Yang, Yue Wei, Mianqin Li, Xiaoqun Che, Qiaoli Zeng, Runmin Guo","doi":"10.2174/0118715303367483250728105845","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>This study aimed to examine the relationship between glucose-dependent insulinotropic polypeptide (GIP) polymorphisms rs3848460 and rs3895874 and the development of gestational diabetes mellitus (GDM) in Asian women. GIP, a hormone that stimulates insulin secretion and inhibits glucagon release, can be impacted by genetic variations, resulting in a reduced insulin response and elevated blood sugar levels that contribute to the development of GDM. To the best of our knowledge, only a limited number of studies have been conducted on the association between GIP gene polymorphisms and GDM.</p><p><strong>Methods: </strong>The SNPscanTM genotyping assay was employed to genotype rs3848460 and rs3895874, with 502 control participants and 500 GDM patients selected for the study. ANOVA, T-test, chi-square test, logistic regression, and various other statistical tests were employed to investigate variations in genotypes and alleles and their associations with the risk of GDM.</p><p><strong>Results: </strong>In this study, significant differences were found in pre-BMI, age, systolic blood pressure, diastolic blood pressure, and parity between GDM and healthy subjects (P < 0.05). In the codominant model, GIP rs3848460 showed a significant association with an increased risk of GDM after adjusting (GG vs. AA: OR = 1.717; 95% CI: 1.070-2.754; P = 0.025. The recessive model GG vs. AG+AA suggests an elevated risk of GDM (adjusted OR of 1.635), with P =0.034. The GG genotype and G allele demonstrated a statistically significant increased risk with an adjusted OR of 1.760 (P =0.026) and an adjusted OR of 1.250 (P =0.029), respectively. The GG genotype and G allele were found to be associated with an increased risk of GDM in GIP rs3848460. Conversely, the risk of GDM was significantly lower in the dominant model (AA+GA vs. GG: OR = 0.605; 95% CI: 0.376-0.974; P = 0.039) for GIP rs3895874. The AA genotype and A allele were correlated with a decreased risk of GDM in GIP rs3895874 after adjustment with an OR of 0.803 (P =0.032).</p><p><strong>Conclusion: </strong>GIP rs3848460 was found to be significantly associated with the risk of GDM. Conversely, the risk of GDM was significantly lower in rs3895874.</p>","PeriodicalId":94316,"journal":{"name":"Endocrine, metabolic & immune disorders drug targets","volume":" ","pages":""},"PeriodicalIF":2.0000,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association of Glucose-Dependent Insulinotropic Polypeptide Receptor Polymorphisms rs3848460 and rs3895874 with the Risk of Gestational Diabetes Mellitus.\",\"authors\":\"Gyan Watson Ray, Hengli Zhang, Taotao Shao, Taili Yang, Yue Wei, Mianqin Li, Xiaoqun Che, Qiaoli Zeng, Runmin Guo\",\"doi\":\"10.2174/0118715303367483250728105845\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>This study aimed to examine the relationship between glucose-dependent insulinotropic polypeptide (GIP) polymorphisms rs3848460 and rs3895874 and the development of gestational diabetes mellitus (GDM) in Asian women. GIP, a hormone that stimulates insulin secretion and inhibits glucagon release, can be impacted by genetic variations, resulting in a reduced insulin response and elevated blood sugar levels that contribute to the development of GDM. To the best of our knowledge, only a limited number of studies have been conducted on the association between GIP gene polymorphisms and GDM.</p><p><strong>Methods: </strong>The SNPscanTM genotyping assay was employed to genotype rs3848460 and rs3895874, with 502 control participants and 500 GDM patients selected for the study. ANOVA, T-test, chi-square test, logistic regression, and various other statistical tests were employed to investigate variations in genotypes and alleles and their associations with the risk of GDM.</p><p><strong>Results: </strong>In this study, significant differences were found in pre-BMI, age, systolic blood pressure, diastolic blood pressure, and parity between GDM and healthy subjects (P < 0.05). In the codominant model, GIP rs3848460 showed a significant association with an increased risk of GDM after adjusting (GG vs. AA: OR = 1.717; 95% CI: 1.070-2.754; P = 0.025. The recessive model GG vs. AG+AA suggests an elevated risk of GDM (adjusted OR of 1.635), with P =0.034. The GG genotype and G allele demonstrated a statistically significant increased risk with an adjusted OR of 1.760 (P =0.026) and an adjusted OR of 1.250 (P =0.029), respectively. The GG genotype and G allele were found to be associated with an increased risk of GDM in GIP rs3848460. Conversely, the risk of GDM was significantly lower in the dominant model (AA+GA vs. GG: OR = 0.605; 95% CI: 0.376-0.974; P = 0.039) for GIP rs3895874. The AA genotype and A allele were correlated with a decreased risk of GDM in GIP rs3895874 after adjustment with an OR of 0.803 (P =0.032).</p><p><strong>Conclusion: </strong>GIP rs3848460 was found to be significantly associated with the risk of GDM. Conversely, the risk of GDM was significantly lower in rs3895874.</p>\",\"PeriodicalId\":94316,\"journal\":{\"name\":\"Endocrine, metabolic & immune disorders drug targets\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-08-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Endocrine, metabolic & immune disorders drug targets\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/0118715303367483250728105845\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Endocrine, metabolic & immune disorders drug targets","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/0118715303367483250728105845","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
背景：本研究旨在探讨亚洲女性葡萄糖依赖性胰岛素性多肽（GIP）多态性rs3848460和rs3895874与妊娠期糖尿病（GDM）发生的关系。GIP是一种刺激胰岛素分泌并抑制胰高血糖素释放的激素，可受到遗传变异的影响，导致胰岛素反应降低和血糖水平升高，从而促进GDM的发展。据我们所知，关于GIP基因多态性与GDM之间关系的研究数量有限。方法：采用SNPscanTM基因分型法对rs3848460和rs3895874进行基因分型，选择502名对照组和500名GDM患者进行研究。采用方差分析（ANOVA）、t检验、卡方检验、逻辑回归和其他各种统计检验来研究基因型和等位基因的变异及其与GDM风险的关系。结果：本研究中，GDM受试者与健康受试者在前bmi、年龄、收缩压、舒张压、胎次等指标上存在显著差异（P < 0.05）。在共显性模型中，调整后GIP rs3848460与GDM风险增加显著相关(GG vs. AA: OR = 1.717；95% ci: 1.070-2.754；P = 0.025。隐性模型GG vs AG+AA提示GDM风险升高（调整OR为1.635），P =0.034。GG基因型和G等位基因分别校正OR为1.760 （P =0.026）和1.250 (P =0.029)，具有统计学意义。在GIP rs3848460中发现GG基因型和G等位基因与GDM风险增加相关。相反，优势模型中GDM的风险显著降低(AA+GA vs. GG: OR = 0.605；95% ci: 0.376-0.974；P = 0.039)为GIP rs3895874。经校正后，AA基因型和A等位基因与GIP rs3895874中GDM风险降低相关，OR为0.803 （P =0.032）。结论：GIP rs3848460与GDM发生风险显著相关。相反，rs3895874的GDM风险显著降低。
Association of Glucose-Dependent Insulinotropic Polypeptide Receptor Polymorphisms rs3848460 and rs3895874 with the Risk of Gestational Diabetes Mellitus.
Background: This study aimed to examine the relationship between glucose-dependent insulinotropic polypeptide (GIP) polymorphisms rs3848460 and rs3895874 and the development of gestational diabetes mellitus (GDM) in Asian women. GIP, a hormone that stimulates insulin secretion and inhibits glucagon release, can be impacted by genetic variations, resulting in a reduced insulin response and elevated blood sugar levels that contribute to the development of GDM. To the best of our knowledge, only a limited number of studies have been conducted on the association between GIP gene polymorphisms and GDM.
Methods: The SNPscanTM genotyping assay was employed to genotype rs3848460 and rs3895874, with 502 control participants and 500 GDM patients selected for the study. ANOVA, T-test, chi-square test, logistic regression, and various other statistical tests were employed to investigate variations in genotypes and alleles and their associations with the risk of GDM.
Results: In this study, significant differences were found in pre-BMI, age, systolic blood pressure, diastolic blood pressure, and parity between GDM and healthy subjects (P < 0.05). In the codominant model, GIP rs3848460 showed a significant association with an increased risk of GDM after adjusting (GG vs. AA: OR = 1.717; 95% CI: 1.070-2.754; P = 0.025. The recessive model GG vs. AG+AA suggests an elevated risk of GDM (adjusted OR of 1.635), with P =0.034. The GG genotype and G allele demonstrated a statistically significant increased risk with an adjusted OR of 1.760 (P =0.026) and an adjusted OR of 1.250 (P =0.029), respectively. The GG genotype and G allele were found to be associated with an increased risk of GDM in GIP rs3848460. Conversely, the risk of GDM was significantly lower in the dominant model (AA+GA vs. GG: OR = 0.605; 95% CI: 0.376-0.974; P = 0.039) for GIP rs3895874. The AA genotype and A allele were correlated with a decreased risk of GDM in GIP rs3895874 after adjustment with an OR of 0.803 (P =0.032).
Conclusion: GIP rs3848460 was found to be significantly associated with the risk of GDM. Conversely, the risk of GDM was significantly lower in rs3895874.
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