{"title":"硫化氢/多硫化物信号与神经元疾病。","authors":"Hideo Kimura","doi":"10.1016/j.neurot.2025.e00711","DOIUrl":null,"url":null,"abstract":"<p><p>Hydrogen sulfide (H<sub>2</sub>S) and polysulfides including H<sub>2</sub>S<sub>n</sub> (n = 2 or more) regulate neuronal activity, vascular tone, oxytosis/ferroptosis, oxygen sensing, cancer growth and senescence. Cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3MST) produce H<sub>2</sub>S. Polysulfides are also produced by various enzymes including 3MST. In addition, transient receptor potential ankyrin 1 (TRPA1) channel-an important polysulfide target-modulates sulfur metabolism (including cysteine, H<sub>2</sub>S and polysulfides) and also affects the neurotransmitter GABA. Polysulfides persulfidate the cysteine residues of the target proteins, causing conformational changes that alter their activity. By contrast, H<sub>2</sub>S persulfidates oxidized cysteine residues (e.g., S-nitrosylated- and S-sulfinated) in its targets. H<sub>2</sub>S/polysulfides protect neurons from oxidative stress and thereby protect cells against various forms of cell death including oxytosis and ferroptosis. A deviation from normal H<sub>2</sub>S and polysulfides levels has been suggested to play a role in the pathophysiology of various neuronal- and psychiatric diseases.</p>","PeriodicalId":19159,"journal":{"name":"Neurotherapeutics","volume":" ","pages":"e00711"},"PeriodicalIF":6.9000,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Hydrogen sulfide/polysulfides signaling and neuronal diseases.\",\"authors\":\"Hideo Kimura\",\"doi\":\"10.1016/j.neurot.2025.e00711\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Hydrogen sulfide (H<sub>2</sub>S) and polysulfides including H<sub>2</sub>S<sub>n</sub> (n = 2 or more) regulate neuronal activity, vascular tone, oxytosis/ferroptosis, oxygen sensing, cancer growth and senescence. Cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3MST) produce H<sub>2</sub>S. Polysulfides are also produced by various enzymes including 3MST. In addition, transient receptor potential ankyrin 1 (TRPA1) channel-an important polysulfide target-modulates sulfur metabolism (including cysteine, H<sub>2</sub>S and polysulfides) and also affects the neurotransmitter GABA. Polysulfides persulfidate the cysteine residues of the target proteins, causing conformational changes that alter their activity. By contrast, H<sub>2</sub>S persulfidates oxidized cysteine residues (e.g., S-nitrosylated- and S-sulfinated) in its targets. H<sub>2</sub>S/polysulfides protect neurons from oxidative stress and thereby protect cells against various forms of cell death including oxytosis and ferroptosis. A deviation from normal H<sub>2</sub>S and polysulfides levels has been suggested to play a role in the pathophysiology of various neuronal- and psychiatric diseases.</p>\",\"PeriodicalId\":19159,\"journal\":{\"name\":\"Neurotherapeutics\",\"volume\":\" \",\"pages\":\"e00711\"},\"PeriodicalIF\":6.9000,\"publicationDate\":\"2025-08-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neurotherapeutics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.neurot.2025.e00711\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurotherapeutics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.neurot.2025.e00711","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Hydrogen sulfide/polysulfides signaling and neuronal diseases.
Hydrogen sulfide (H2S) and polysulfides including H2Sn (n = 2 or more) regulate neuronal activity, vascular tone, oxytosis/ferroptosis, oxygen sensing, cancer growth and senescence. Cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3MST) produce H2S. Polysulfides are also produced by various enzymes including 3MST. In addition, transient receptor potential ankyrin 1 (TRPA1) channel-an important polysulfide target-modulates sulfur metabolism (including cysteine, H2S and polysulfides) and also affects the neurotransmitter GABA. Polysulfides persulfidate the cysteine residues of the target proteins, causing conformational changes that alter their activity. By contrast, H2S persulfidates oxidized cysteine residues (e.g., S-nitrosylated- and S-sulfinated) in its targets. H2S/polysulfides protect neurons from oxidative stress and thereby protect cells against various forms of cell death including oxytosis and ferroptosis. A deviation from normal H2S and polysulfides levels has been suggested to play a role in the pathophysiology of various neuronal- and psychiatric diseases.
期刊介绍：
Neurotherapeutics® is the journal of the American Society for Experimental Neurotherapeutics (ASENT). Each issue provides critical reviews of an important topic relating to the treatment of neurological disorders written by international authorities.
The Journal also publishes original research articles in translational neuroscience including descriptions of cutting edge therapies that cross disciplinary lines and represent important contributions to neurotherapeutics for medical practitioners and other researchers in the field.
Neurotherapeutics ® delivers a multidisciplinary perspective on the frontiers of translational neuroscience, provides perspectives on current research and practice, and covers social and ethical as well as scientific issues.
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