Syed H Haq, Riley Pulver, Hoshimjon Begmatov, Candace Downing, Amanda Laird, Sandeep M Patel, Sreenivasa Chanamolu, William Cole
{"title":"体外膜氧合治疗难治性肺内出血手术止血的新应用。","authors":"Syed H Haq, Riley Pulver, Hoshimjon Begmatov, Candace Downing, Amanda Laird, Sandeep M Patel, Sreenivasa Chanamolu, William Cole","doi":"10.1097/CCE.0000000000001301","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Intrapulmonary hemorrhage (IPH) is a life-threatening condition associated with specific risk factors including prolonged mechanical ventilation, therapeutic anticoagulation, and notably, mechanical circulatory support (MCS). MCS creates a constellation of conditions that predispose patients to IPH. Given the need for systemic anticoagulation and concomitant critical illness, managing IPH can be challenging. Consequently, extracorporeal membrane oxygenation (ECMO) is accompanied by an increased mortality rate.</p><p><strong>Case summary: </strong>We present a case of a patient on ECMO complicated by severe intrapulmonary bleeding refractory to conventional therapies, but responded to the novel application of Surgiflo (a hemostatic matrix) to achieve hemostasis.</p><p><strong>Conclusions: </strong>Endobronchial application of Surgiflo provides a viable option to manage refractory IPH.</p>","PeriodicalId":93957,"journal":{"name":"Critical care explorations","volume":"7 8","pages":"e1301"},"PeriodicalIF":2.7000,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12330348/pdf/","citationCount":"0","resultStr":"{\"title\":\"The Novel Application of Surgiflo and Successful Hemostasis of Refractory Intrapulmonary Hemorrhage in Extracorporeal Membrane Oxygenation.\",\"authors\":\"Syed H Haq, Riley Pulver, Hoshimjon Begmatov, Candace Downing, Amanda Laird, Sandeep M Patel, Sreenivasa Chanamolu, William Cole\",\"doi\":\"10.1097/CCE.0000000000001301\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Intrapulmonary hemorrhage (IPH) is a life-threatening condition associated with specific risk factors including prolonged mechanical ventilation, therapeutic anticoagulation, and notably, mechanical circulatory support (MCS). MCS creates a constellation of conditions that predispose patients to IPH. Given the need for systemic anticoagulation and concomitant critical illness, managing IPH can be challenging. Consequently, extracorporeal membrane oxygenation (ECMO) is accompanied by an increased mortality rate.</p><p><strong>Case summary: </strong>We present a case of a patient on ECMO complicated by severe intrapulmonary bleeding refractory to conventional therapies, but responded to the novel application of Surgiflo (a hemostatic matrix) to achieve hemostasis.</p><p><strong>Conclusions: </strong>Endobronchial application of Surgiflo provides a viable option to manage refractory IPH.</p>\",\"PeriodicalId\":93957,\"journal\":{\"name\":\"Critical care explorations\",\"volume\":\"7 8\",\"pages\":\"e1301\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2025-08-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12330348/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Critical care explorations\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1097/CCE.0000000000001301\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/8/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Critical care explorations","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/CCE.0000000000001301","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
The Novel Application of Surgiflo and Successful Hemostasis of Refractory Intrapulmonary Hemorrhage in Extracorporeal Membrane Oxygenation.
Background: Intrapulmonary hemorrhage (IPH) is a life-threatening condition associated with specific risk factors including prolonged mechanical ventilation, therapeutic anticoagulation, and notably, mechanical circulatory support (MCS). MCS creates a constellation of conditions that predispose patients to IPH. Given the need for systemic anticoagulation and concomitant critical illness, managing IPH can be challenging. Consequently, extracorporeal membrane oxygenation (ECMO) is accompanied by an increased mortality rate.
Case summary: We present a case of a patient on ECMO complicated by severe intrapulmonary bleeding refractory to conventional therapies, but responded to the novel application of Surgiflo (a hemostatic matrix) to achieve hemostasis.
Conclusions: Endobronchial application of Surgiflo provides a viable option to manage refractory IPH.