Kirstin J Kooda, Julia Nelson, Sara E Ausman, Christina G Rivera, Omar M Abu Saleh, Andrew D Rule, Ryan W Stevens, Micaela N Warfield, Yanjun Zhao, Erin F Barreto
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引用次数: 0
摘要
本研究旨在确定延长输注(EI；与传统剂量相比，β -内酰胺治疗增加了静脉通路需求(TD；超过30分钟)。本研究纳入86例接受TD抗假单胞菌β -内酰胺类药物治疗并接受治疗药物监测（TDM）的ICU患者。TDM后从TD过渡到EI的患者（EI组）与继续使用TD的患者1:1匹配。在初步分析中，TDM前24小时与TDM后48小时的中位数（四分位数范围）总流明数在两组之间相似(TDM前：TDM 3 [2-5] vs. EI 4 [3-5]；p = 0.22后：TD 3 [2-4] vs EI 4 [3-5]；P = 0.05)。β -内酰胺经EI输送与需要更多静脉注射无关。实际的挑战，如获取不应限制使用EI β -内酰胺时指出。
Impact of Extending Beta-Lactam Infusions on IV Access Requirements.
This study aimed to determine if extended infusion (EI; over > 3 hr) beta-lactam therapy increased IV access requirements compared with traditional dosing (TD; over 30 min). Eighty-six adult ICU patients treated with TD anti-pseudomonal beta-lactams who underwent therapeutic drug monitoring (TDM) were included. Patients who transitioned from TD to EI after TDM (EI group) were matched 1:1 to patients who remained on TD. In the primary analysis, the median (interquartile range) total number of lumens in the 24 hours before TDM compared with the 48 hours after TDM were similar between groups (pre: TD 3 [2-5] vs. EI 4 [3-5]; p = 0.22 and post: TD 3 [2-4] vs. EI 4 [3-5]; p = 0.05). Delivery of beta-lactams via EI was not associated with a need for more IV access. Practical challenges such as access should not limit use of EI beta-lactams when indicated.
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