Weilin Song , Adrian Au , Angela Oh , Alan W. Kong , James Lamb , Tara A. McCannel
{"title":"近距离治疗葡萄膜黑色素瘤的辅助继发斑块。","authors":"Weilin Song , Adrian Au , Angela Oh , Alan W. Kong , James Lamb , Tara A. McCannel","doi":"10.1016/j.brachy.2025.05.003","DOIUrl":null,"url":null,"abstract":"<div><h3>PURPOSE</h3><div>We describe the technique, indications and outcomes of an accessory secondary brachytherapy plaque for the treatment of uveal melanoma to provide supplemental tumor coverage for the primary brachytherapy plaque.</div></div><div><h3>METHODS</h3><div>Retrospective case series was performed to identify brachytherapy plaque cases for the treatment of primary uveal melanoma where an accessory secondary plaque was created to improve treatment coverage of the uveal melanoma, and positioned at the time of removal of the primary brachytherapy plaque. Baseline tumor, patient characteristics, and clinical outcomes including tumor control, visual acuity, treatment complications, metastases and death treatment were obtained.</div></div><div><h3>RESULTS</h3><div>Of 1,144 uveal melanomas treated with brachytherapy over a 19-year period, eight (0.7%) cases were identified where an accessory secondary brachytherapy plaque was used. Six (75%) patients had uveal melanoma involving the ciliary body. After a mean follow up period of 31.5 ± 5.65 (SE) months, seven (87.5%) patients maintained tumor control and the mean visual acuity was logMAR 0.84 ± 0.57 (Snellen equivalent 20/138). Two (25%) patients developed metastasis, and one (12.5%) patient died of metastatic disease.</div></div><div><h3>CONCLUSION</h3><div>An accessory brachytherapy plaque is a practical solution to manage unexpected deficiencies in plaque coverage of the primary melanoma which avoids treatment delay and minimizes time for potential tumor growth. It may also avoid suboptimal adjunctive treatment options, such as transpupillary thermotherapy, and eliminates radioactive source loss if an entirely new brachytherapy plaque was created. A well-matched accessory secondary plaque may also better conform to the target than a generic plaque with a larger diameter.</div></div>","PeriodicalId":55334,"journal":{"name":"Brachytherapy","volume":"24 5","pages":"Pages 807-813"},"PeriodicalIF":1.8000,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Accessory secondary plaque in brachytherapy for uveal melanoma\",\"authors\":\"Weilin Song , Adrian Au , Angela Oh , Alan W. Kong , James Lamb , Tara A. McCannel\",\"doi\":\"10.1016/j.brachy.2025.05.003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>PURPOSE</h3><div>We describe the technique, indications and outcomes of an accessory secondary brachytherapy plaque for the treatment of uveal melanoma to provide supplemental tumor coverage for the primary brachytherapy plaque.</div></div><div><h3>METHODS</h3><div>Retrospective case series was performed to identify brachytherapy plaque cases for the treatment of primary uveal melanoma where an accessory secondary plaque was created to improve treatment coverage of the uveal melanoma, and positioned at the time of removal of the primary brachytherapy plaque. Baseline tumor, patient characteristics, and clinical outcomes including tumor control, visual acuity, treatment complications, metastases and death treatment were obtained.</div></div><div><h3>RESULTS</h3><div>Of 1,144 uveal melanomas treated with brachytherapy over a 19-year period, eight (0.7%) cases were identified where an accessory secondary brachytherapy plaque was used. Six (75%) patients had uveal melanoma involving the ciliary body. After a mean follow up period of 31.5 ± 5.65 (SE) months, seven (87.5%) patients maintained tumor control and the mean visual acuity was logMAR 0.84 ± 0.57 (Snellen equivalent 20/138). Two (25%) patients developed metastasis, and one (12.5%) patient died of metastatic disease.</div></div><div><h3>CONCLUSION</h3><div>An accessory brachytherapy plaque is a practical solution to manage unexpected deficiencies in plaque coverage of the primary melanoma which avoids treatment delay and minimizes time for potential tumor growth. It may also avoid suboptimal adjunctive treatment options, such as transpupillary thermotherapy, and eliminates radioactive source loss if an entirely new brachytherapy plaque was created. A well-matched accessory secondary plaque may also better conform to the target than a generic plaque with a larger diameter.</div></div>\",\"PeriodicalId\":55334,\"journal\":{\"name\":\"Brachytherapy\",\"volume\":\"24 5\",\"pages\":\"Pages 807-813\"},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2025-08-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Brachytherapy\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1538472125000881\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brachytherapy","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1538472125000881","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}
Accessory secondary plaque in brachytherapy for uveal melanoma
PURPOSE
We describe the technique, indications and outcomes of an accessory secondary brachytherapy plaque for the treatment of uveal melanoma to provide supplemental tumor coverage for the primary brachytherapy plaque.
METHODS
Retrospective case series was performed to identify brachytherapy plaque cases for the treatment of primary uveal melanoma where an accessory secondary plaque was created to improve treatment coverage of the uveal melanoma, and positioned at the time of removal of the primary brachytherapy plaque. Baseline tumor, patient characteristics, and clinical outcomes including tumor control, visual acuity, treatment complications, metastases and death treatment were obtained.
RESULTS
Of 1,144 uveal melanomas treated with brachytherapy over a 19-year period, eight (0.7%) cases were identified where an accessory secondary brachytherapy plaque was used. Six (75%) patients had uveal melanoma involving the ciliary body. After a mean follow up period of 31.5 ± 5.65 (SE) months, seven (87.5%) patients maintained tumor control and the mean visual acuity was logMAR 0.84 ± 0.57 (Snellen equivalent 20/138). Two (25%) patients developed metastasis, and one (12.5%) patient died of metastatic disease.
CONCLUSION
An accessory brachytherapy plaque is a practical solution to manage unexpected deficiencies in plaque coverage of the primary melanoma which avoids treatment delay and minimizes time for potential tumor growth. It may also avoid suboptimal adjunctive treatment options, such as transpupillary thermotherapy, and eliminates radioactive source loss if an entirely new brachytherapy plaque was created. A well-matched accessory secondary plaque may also better conform to the target than a generic plaque with a larger diameter.
期刊介绍:
Brachytherapy is an international and multidisciplinary journal that publishes original peer-reviewed articles and selected reviews on the techniques and clinical applications of interstitial and intracavitary radiation in the management of cancers. Laboratory and experimental research relevant to clinical practice is also included. Related disciplines include medical physics, medical oncology, and radiation oncology and radiology. Brachytherapy publishes technical advances, original articles, reviews, and point/counterpoint on controversial issues. Original articles that address any aspect of brachytherapy are invited. Letters to the Editor-in-Chief are encouraged.