Licochalcone A通过触发线粒体功能障碍和ros介导的氧化损伤来抑制胶质瘤的迁移、侵袭和生长。

IF 3.7 2区 生物学 Q3 CELL BIOLOGY
Chao Yu, Deyan Yang, Nannan Li, Xiaotong Feng, Qile Song, Fusen Zhang, Yuyang Fu, Ping Li
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引用次数: 0

摘要

胶质瘤是一种常见的神经系统恶性肿瘤,但治疗效果仍不理想。甘草查尔酮A (Licochalcone A, Lic-A)是从甘草中分离得到的一类具有抗肿瘤作用的类黄酮。本研究旨在通过体内和体外模型研究lica对胶质瘤的抗肿瘤作用。体外实验结果显示,lica抑制胶质瘤细胞的生长、迁移和侵袭呈剂量依赖性。lica通过调节Bcl-2家族和诱导活性氧(ROS)诱导线粒体功能障碍,而抑制活性氧可增强胶质瘤细胞的迁移和侵袭。最后,动物实验证实lica在体内抑制胶质瘤的生长。综上所述,我们的研究结果表明lica可以抑制胶质瘤细胞的迁移和侵袭,同时诱导胶质瘤细胞凋亡。其机制可能与激活ATM/ATR通路,诱导氧化应激有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Licochalcone A inhibits glioma migration, invasion, and growth by triggering mitochondrial dysfunction and ROS-mediated oxidative damage.

Glioma is a common malignant tumor in nervous system, but the treatment efficacy is still unsatisfactory. Licochalcone A (Lic-A) is a kind of flavonoid isolated from glycyrrhiza and shows anti-tumor effect. This study aimed to investigate anti-tumor efficacy of Lic-A on glioma using both in vivo and in vitro models. The in vitro results showed that Lic-A inhibited the growth, migration, and invasion of glioma cells in a dose-dependent way. Lic-A induced mitochondrial dysfunction by regulating Bcl-2 family and induced reactive oxygen species (ROS), while ROS inhibition enhanced the migration and invasion of glioma cells. Finally, animal experiments confirmed that Lic-A inhibited the growth of glioma in vivo. In conclusion, our results suggest that Lic-A can inhibit the migration and invasion of glioma cells while inducing apoptosis of glioma cells. The mechanism may be related to the activation of ATM/ATR pathway and the induction of oxidative stress.

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来源期刊
Molecular and Cellular Biochemistry
Molecular and Cellular Biochemistry 生物-细胞生物学
CiteScore
8.30
自引率
2.30%
发文量
293
审稿时长
1.7 months
期刊介绍: Molecular and Cellular Biochemistry: An International Journal for Chemical Biology in Health and Disease publishes original research papers and short communications in all areas of the biochemical sciences, emphasizing novel findings relevant to the biochemical basis of cellular function and disease processes, as well as the mechanics of action of hormones and chemical agents. Coverage includes membrane transport, receptor mechanism, immune response, secretory processes, and cytoskeletal function, as well as biochemical structure-function relationships in the cell. In addition to the reports of original research, the journal publishes state of the art reviews. Specific subjects covered by Molecular and Cellular Biochemistry include cellular metabolism, cellular pathophysiology, enzymology, ion transport, lipid biochemistry, membrane biochemistry, molecular biology, nuclear structure and function, and protein chemistry.
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