间质细胞睾酮合成的表观遗传调控研究进展。

IF 3.7 2区 生物学 Q3 CELL BIOLOGY
Haoran Xu, Jing Zhao, Wenfa Lyu, Jun Wang
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引用次数: 0

摘要

表观遗传学研究在不改变DNA序列的情况下基因表达的可遗传变化,并涉及多种生物过程。在雄性生殖中,间质细胞是睾酮合成的主要部位,在维持生殖过程中起着重要作用。然而,表观遗传学在间质细胞中睾酮合成机制中的作用尚不清楚。本文系统地介绍了DNA甲基化、RNA甲基化、组蛋白修饰和非编码RNA等经典表观遗传修饰如何调节不同物种间质细胞的睾酮合成过程。越来越多的证据表明,表观遗传学可以调节间质细胞的睾酮合成过程。未来,我们的目标是通过研究睾酮合成机制与表观遗传学的关系,为男性生殖提供新的思路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A review on the epigenetic regulation of testosterone synthesis in Leydig cells.

Epigenetics studies heritable changes in gene expression without altering the DNA sequence and is involved in diverse biological processes. In male reproduction, Leydig cells, the main site of testosterone synthesis, play an important role in maintaining the reproductive process. However, the role of epigenetics in the mechanism of testosterone synthesis in Leydig cells is still not well understood. This review systematically describes how classic epigenetic modifications such as DNA methylation, RNA methylation, histone modification, and non-coding RNA regulate the testosterone synthesis process of Leydig cells in different species. Accumulating evidences revealed that epigenetics can regulate the process of testosterone synthesis in Leydig cells. In future, we aim to provide new ideas for male reproduction by investigating the relationship between testosterone synthesis mechanisms and epigenetics.

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来源期刊
Molecular and Cellular Biochemistry
Molecular and Cellular Biochemistry 生物-细胞生物学
CiteScore
8.30
自引率
2.30%
发文量
293
审稿时长
1.7 months
期刊介绍: Molecular and Cellular Biochemistry: An International Journal for Chemical Biology in Health and Disease publishes original research papers and short communications in all areas of the biochemical sciences, emphasizing novel findings relevant to the biochemical basis of cellular function and disease processes, as well as the mechanics of action of hormones and chemical agents. Coverage includes membrane transport, receptor mechanism, immune response, secretory processes, and cytoskeletal function, as well as biochemical structure-function relationships in the cell. In addition to the reports of original research, the journal publishes state of the art reviews. Specific subjects covered by Molecular and Cellular Biochemistry include cellular metabolism, cellular pathophysiology, enzymology, ion transport, lipid biochemistry, membrane biochemistry, molecular biology, nuclear structure and function, and protein chemistry.
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