Christian Rosendal, Annika Vestergaard Kvist, Rogério Pessoto Hirata, Peter Vestergaard, Jakob Dal
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In this study, we aimed to assess the balance in patients with long-term acromegaly compared to non-acromegalic controls.</p>\n </section>\n \n <section>\n \n <h3> Design</h3>\n \n <p>Cross-sectional study.</p>\n </section>\n \n <section>\n \n <h3> Patients and Measurements</h3>\n \n <p>Seventeen patients with acromegaly and 17 age- and sex-matched controls were examined using a force platform measuring the Centre of Pressure area (CoP<sub>area</sub>) and velocity (CoP<sub>velocity</sub>), the timed up-and-go (TUG) test, hand grip and knee extension dynamometry, nerve conduction measurements, visual acuity tests, and questionnaires concerning fear of falling and joint pain (Falls Efficacy Scale [FES-I] and Western Ontario and McMaster Universities Osteoarthritis Index [WOMAC]). Descriptive statistics and linear regression analyses were used to compare groups.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Compared to controls, participants with acromegaly (mean acromegaly duration 13 [±8.8] years, latest mean IGF-I standard deviation score 1.2 [±1.59]) had significantly increased CoP<sub>area</sub> adjusted for neural and visual function. When performing a difficult executive task, the CoP<sub>area</sub> was impaired, both with (<i>β</i>: 2.24 [1.29; 3.92], <i>p</i> = 0.01) and without (<i>β</i>: 2.09 [1.02; 4.26], <i>p</i> = 0.04) a cushion under their feet, as compared to controls. Mean TUG time was significantly higher in patients with acromegaly than controls (<i>β</i>: 1.24 [0.07; 2.42], <i>p</i> = 0.04), and correlated with self-reported joint pain (<i>β</i>: 0.04 [0.0004; 0.08], <i>p</i> = 0.05).</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Both static and dynamic balance is impaired in patients with long-term controlled acromegaly, warranting clinical attention. Further studies are needed to address therapeutic options for this overlooked and potentially serious complication.</p>\n </section>\n </div>","PeriodicalId":10346,"journal":{"name":"Clinical Endocrinology","volume":"103 5","pages":"703-710"},"PeriodicalIF":2.4000,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cen.70010","citationCount":"0","resultStr":"{\"title\":\"Static and Dynamic Balance Is Impaired in Patients With Long-Term, Well-Controlled Acromegaly: A Cross-Sectional Study\",\"authors\":\"Christian Rosendal, Annika Vestergaard Kvist, Rogério Pessoto Hirata, Peter Vestergaard, Jakob Dal\",\"doi\":\"10.1111/cen.70010\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Objective</h3>\\n \\n <p>Balance impairment is an underrecognized complication of acromegaly with potentially serious consequences for affected patients. 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引用次数: 0
摘要
目的：平衡障碍是肢端肥大症的一种未被充分认识的并发症，对患者有潜在的严重后果。在这项研究中，我们旨在评估长期肢端肥大症患者与非肢端肥大症对照组的平衡。设计：横断面研究。患者及测量：17例肢端肥大症患者和17例年龄和性别匹配的对照组采用测量压力中心面积（CoParea）和速度（CoPvelocity）的力平台、时间起落（TUG）测试、手部握力和膝关节伸展力测量、神经传导测量、视力测试和关于害怕跌倒和关节疼痛的问卷（跌倒疗效量表[FES-I]和西安大略省和麦克马斯特大学骨关节炎指数[WOMAC]）进行检查。组间比较采用描述性统计和线性回归分析。结果：与对照组相比，肢端肥大症患者（肢端肥大症平均病程13[±8.8]年，最近平均IGF-I标准差评分1.2[±1.59]）的神经和视觉功能调整后的CoParea显著增加。当执行困难的执行任务时，CoParea受损，均为(β: 2.24 [1.29；3.92], p = 0.01)和无(β: 2.09 [1.02；4.26], p = 0.04)，与对照组相比，他们脚下有一个垫子。肢端肥大症患者的平均TUG时间显著高于对照组(β: 1.24 [0.07；2.42], p = 0.04)，且与自我报告的关节疼痛相关(β: 0.04 [0.0004；0.08], p = 0.05)。结论：长期控制肢端肥大症患者的静态和动态平衡均受损，值得临床注意。需要进一步的研究来解决这种被忽视的潜在严重并发症的治疗选择。
Static and Dynamic Balance Is Impaired in Patients With Long-Term, Well-Controlled Acromegaly: A Cross-Sectional Study
Objective
Balance impairment is an underrecognized complication of acromegaly with potentially serious consequences for affected patients. In this study, we aimed to assess the balance in patients with long-term acromegaly compared to non-acromegalic controls.
Design
Cross-sectional study.
Patients and Measurements
Seventeen patients with acromegaly and 17 age- and sex-matched controls were examined using a force platform measuring the Centre of Pressure area (CoParea) and velocity (CoPvelocity), the timed up-and-go (TUG) test, hand grip and knee extension dynamometry, nerve conduction measurements, visual acuity tests, and questionnaires concerning fear of falling and joint pain (Falls Efficacy Scale [FES-I] and Western Ontario and McMaster Universities Osteoarthritis Index [WOMAC]). Descriptive statistics and linear regression analyses were used to compare groups.
Results
Compared to controls, participants with acromegaly (mean acromegaly duration 13 [±8.8] years, latest mean IGF-I standard deviation score 1.2 [±1.59]) had significantly increased CoParea adjusted for neural and visual function. When performing a difficult executive task, the CoParea was impaired, both with (β: 2.24 [1.29; 3.92], p = 0.01) and without (β: 2.09 [1.02; 4.26], p = 0.04) a cushion under their feet, as compared to controls. Mean TUG time was significantly higher in patients with acromegaly than controls (β: 1.24 [0.07; 2.42], p = 0.04), and correlated with self-reported joint pain (β: 0.04 [0.0004; 0.08], p = 0.05).
Conclusions
Both static and dynamic balance is impaired in patients with long-term controlled acromegaly, warranting clinical attention. Further studies are needed to address therapeutic options for this overlooked and potentially serious complication.
期刊介绍：
Clinical Endocrinology publishes papers and reviews which focus on the clinical aspects of endocrinology, including the clinical application of molecular endocrinology. It does not publish papers relating directly to diabetes care and clinical management. It features reviews, original papers, commentaries, correspondence and Clinical Questions. Clinical Endocrinology is essential reading not only for those engaged in endocrinological research but also for those involved primarily in clinical practice.
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