2型糖尿病的酒精消耗、酒精代谢酶基因型和血糖控制:来自福冈糖尿病登记处的性别特异性发现

IF 3 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Toshiaki Ohkuma, Masanori Iwase, Ayaka Oshiro, Taiki Higashi, Takanari Kitazono
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引用次数: 0

摘要

目的/简介:目前尚不清楚饮酒与血糖水平之间的性别特异性关联,以及这种关联是否因酒精遗传易感性而不同。本研究旨在研究东亚2型糖尿病患者饮酒和酒精代谢酶基因变异与血糖水平的关系,以及它们的性别差异。材料和方法:共纳入4923名日本2型糖尿病患者。参与者根据饮酒状况进行分类,饮酒量(1c水平)进行横断面检查。结果:在男性中,与从不饮酒者相比,饮酒量的增加与HbA1c水平的降低相关(P为1c趋势水平),而≥20 g/天的饮酒量与HbA1c水平升高相关,呈j型关系。关于与酒精代谢酶遗传变异的关系,HbA1c随着ALDH2中A等位基因数量的增加而线性增加(趋势1c水平的P在ADH1B基因型中没有显示出显著的趋势。酒精摄入量和HbA1c水平之间的关系不受ADH1B或ALDH2基因变异的影响。结论:这些发现强调了针对2型糖尿病患者酒精代谢的遗传易感性,采用性别特异性方法控制饮酒习惯对血糖控制的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Alcohol consumption, alcohol-metabolizing enzyme genotypes, and glycemic control in type 2 diabetes: Sex-specific findings from the Fukuoka Diabetes Registry

Alcohol consumption, alcohol-metabolizing enzyme genotypes, and glycemic control in type 2 diabetes: Sex-specific findings from the Fukuoka Diabetes Registry

Aims/Introduction

The sex-specific association between alcohol consumption and glycemic level and whether the association differs by genetic susceptibility to alcohol is unclear. The present study aimed to examine the association of alcohol consumption and genetic variants in alcohol-metabolizing enzymes with glycemic level, as well as their sex differences, in East Asian individuals with type 2 diabetes.

Materials and Methods

In total, 4,923 Japanese individuals with type 2 diabetes were included. Participants were classified based on alcohol drinking status, alcohol consumption amount (<20, 20–39, or ≥40 g/day), and ADH1B (rs1229984) and ALDH2 (rs671) genotype, and the associations with HbA1c levels were examined cross-sectionally.

Results

In men, compared with never drinkers, an increase in the alcohol consumption amount was associated with a decrease in HbA1c levels (P for trend <0.001). By contrast, in women, a mild-to-moderate consumption amount (<20 g/day) was associated with decreased HbA1c levels, whereas ≥20 g/day consumption was associated with increased HbA1c levels, indicating a J-shaped relationship. Regarding the association with genetic variants in alcohol-metabolizing enzymes, HbA1c increased linearly with an increasing number of A alleles in ALDH2 (P for trend <0.001). However, the HbA1c level did not show a significant trend across the ADH1B genotype. The association between alcohol consumption and HbA1c levels was not modified by genetic variants in ADH1B or ALDH2.

Conclusions

These findings highlight the importance of a sex-specific approach to alcohol drinking habits in managing glycemic control for individuals with type 2 diabetes, irrespective of genetic predisposition to alcohol metabolism.

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来源期刊
Journal of Diabetes Investigation
Journal of Diabetes Investigation ENDOCRINOLOGY & METABOLISM-
CiteScore
6.50
自引率
9.40%
发文量
218
审稿时长
6-12 weeks
期刊介绍: Journal of Diabetes Investigation is your core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes (AASD). The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. Embracing clinical and experimental research in diabetes and related areas, the Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology. Translational research focused on the exchange of ideas between clinicians and researchers is also welcome. Journal of Diabetes Investigation is indexed by Science Citation Index Expanded (SCIE).
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