脑出血后运动恢复的长期时间特征。

IF 3.9 2区 医学 Q1 CLINICAL NEUROLOGY
Yan Zheng, Fu-Xin Lin, Ling-Yun Zhuo, Jian-Cai Chen, Xin Ge, Xiang-Lin Chen, Xue-Jiao Wang, Zhi-Gang Yao, You-Liang Tong, Bo Xie, Bai-Hai Guo, Zhao-Sheng Sun, Zhi-Hua Tian, Ping Qiu, Xin-Ru Lin, Qiu He, Shu-Na Huang, Ke Ma, Fang-Yu Wang, Huang-Cheng Shang-Guan, Wen-Hua Fang, Deng-Liang Wang, Ying Fu, Yuan-Xiang Lin, De-Zhi Kang
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引用次数: 0

摘要

目的:有限的数据可以描述自发性脑出血(ICH)患者中风后1年长期恢复的时间概况。方法:2013年11月至2023年1月,采用注册多中心队列,连续纳入非疝出的幕上脑出血患者。符合条件的患者分别在入组后3个月、6个月、1年和每年接受随访,直至死亡或研究终止。运动恢复的结果用独立站立能力二分法进行评估。对相关因素、恢复率和时间分布进行分析。结果:在1624例符合条件的应答中,105例(6.5%)在卒中后1年后恢复了运动功能。运动恢复过程随时间延长而缩短,持续到44个月,1年和长期累计恢复率分别为71.3% (95% CI: 69.0% ~ 73.5%)和80.2% (95% CI: 78.0% ~ 82.5%)。此外,发病年龄、脑出血部位、脑出血较大、外周血肿(PHE)、脑室内延伸、GCS评分和入院医院级别是影响运动结果的独立因素(均为p)解释:卒中后恢复持续超过1年,直到发病后约3年,运动恢复延迟的患者约占最终康复患者的10%。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Long-Term Temporal Profile of Motor Recovery After Intracerebral Hemorrhage.

Objective: Limited data is available to describe the temporal profile of long-term recovery over 1 year after the stroke in patients with spontaneous intracerebral hemorrhage (ICH).

Methods: A registered multicentral cohort was conducted to consecutively include non-herniated supratentorial ICH patients from November 2013 to January 2023. Eligible patients received follow-ups at the time of 3 months, 6 months, 1 year, and each year after the enrollments until death or the study termination. The outcome of motor recovery was assessed with the dichotomy of independent standing ability. Analyses were performed to investigate the associated factors, recovery rates, and temporal profile.

Results: Of 1624 eligible responses, 105 (6.5%) regained motor recovery beyond 1 year after the stroke. The motor recovery course decreased with time and continued until 44 months, with 1-year and long-term cumulative recovery rates of 71.3% (95% CI: 69.0%-73.5%) and 80.2% (95% CI: 78.0%-82.5%), respectively. Moreover, the onset age, ICH location, larger ICH, and peripheral hematomal edema (PHE), intraventricular extension, GCS score, and admission hospital tier were independent factors on the motor outcome (all p < 0.05). However, the older age (aHR = 0.97/year, 95% CI: 0.95-0.98, p < 0.001) was identified as the only hazard factor for future recovery in patients who were incapable of recovery within 1 year.

Interpretation: The poststroke recovery was ongoing beyond 1 year until about 3 years after the onset, and those with delayed motor recovery accounted for about 10% of ultimately recovered patients.

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来源期刊
Annals of Clinical and Translational Neurology
Annals of Clinical and Translational Neurology Medicine-Neurology (clinical)
CiteScore
9.10
自引率
1.90%
发文量
218
审稿时长
8 weeks
期刊介绍: Annals of Clinical and Translational Neurology is a peer-reviewed journal for rapid dissemination of high-quality research related to all areas of neurology. The journal publishes original research and scholarly reviews focused on the mechanisms and treatments of diseases of the nervous system; high-impact topics in neurologic education; and other topics of interest to the clinical neuroscience community.
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