坏疽样脓皮溃疡与小血管炎的相关性（血管炎表现为坏疽样脓皮溃疡）。

IF 1.8 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

American Journal of the Medical Sciences Pub Date : 2025-08-05 DOI:10.1016/j.amjms.2025.08.006

Zaynab Marzuk MD , Yamen Homsi MD, MPH (Assistant Professor and Section Chief) , Ata S. Moshiri MD, MPH (Assistant Professor) , Theodora K Karagounis MD (Clinical Assistant Professor)

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引用次数: 0

摘要

坏疽性脓皮病（Pyoderma gangrenosum， PG）最早由法国皮肤科医生Louis-Anne-Jean Brocq描述为一种“软组织迅速蔓延的溃疡”组织学上，PG是一种中性粒细胞性皮肤病，表现为疼痛性溃疡。已知它与自身免疫介导的疾病（如血管炎）有关及时的组织活检确诊和免疫抑制剂治疗至关重要我们报告一个独特的病例pg样病变相关的小血管炎在一个47岁的男子。在开始甲氨蝶呤治疗后，患者的病变明显改善，突出了识别与血管炎相关的pg样病变的重要性。

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Pyoderma gangrenosum-like ulcer association in small vessel vasculitis (Vasculitis presenting as pyoderma gangrenosum-like ulcer)

Pyoderma gangrenosum (PG) was first described by French Dermatologist Louis-Anne-Jean Brocq as a “rapidly spreading ulceration of soft tissue”.¹ Histologically, PG is a neutrophilic dermatosis presenting as painful ulcerations. It is known to be associated with autoimmune-mediated disorders such as vasculitis.² Timely confirmatory diagnosis with tissue biopsy and management with immunosuppressive agents are critical.¹ We report a unique case of a PG-like lesion related to small vessel vasculitis in a 47-year-old man. Following the initiation of methotrexate (Methotrexate) therapy, the patient’s lesions improved significantly, highlighting the importance of recognizing PG-like lesions associated with vasculitis.

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来源期刊

American Journal of the Medical Sciences 医学-医学：内科

CiteScore

4.40

自引率

0.00%

发文量

303

审稿时长

1.5 months

期刊介绍： The American Journal of The Medical Sciences (AJMS), founded in 1820, is the 2nd oldest medical journal in the United States. The AJMS is the official journal of the Southern Society for Clinical Investigation (SSCI). The SSCI is dedicated to the advancement of medical research and the exchange of knowledge, information and ideas. Its members are committed to mentoring future generations of medical investigators and promoting careers in academic medicine. The AJMS publishes, on a monthly basis, peer-reviewed articles in the field of internal medicine and its subspecialties, which include: Original clinical and basic science investigations Review articles Online Images in the Medical Sciences Special Features Include: Patient-Centered Focused Reviews History of Medicine The Science of Medical Education.