澳大利亚丙型肝炎感染风险人群对简化丙型肝炎检测方式的患者偏好：SELECT研究

IF 4.4 2区医学 Q1 SUBSTANCE ABUSE

International Journal of Drug Policy Pub Date : 2025-08-05 DOI:10.1016/j.drugpo.2025.104871

Annabelle Stevens , Jake Abbott , Loriate Gribbin , Sarah Ahmed , Mark Montebello , Peter Ellis-Jones , Thao Lam , Meryem Jefferies , Mim O’Flynn , Joss O’Loan , Alex Wade , Anita Hoskins , Laura Johnson , Amie Johns , Victoria Cock , Mary E. Harrod , David Silk , Alison D. Marshall , Gregory J. Dore , Jason Grebely , Evan B. Cunningham

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引用次数: 0

摘要

背景：了解患者对丙型肝炎病毒（HCV）检测的偏好对于提高吸收和支持消除工作至关重要。尽管有创新的测试模式，但有限的研究探讨了偏好如何影响测试选择。本研究比较了参与者在选择丙型肝炎病毒检测方式时的接受情况。方法从澳大利亚丙型肝炎即时检测项目的社区站点招募有丙型肝炎风险的人群。参与者使用视觉辅助工具概述测试特征，包括结果时间和收集方法。报告既往HCV感染的患者接受工作人员辅助的HCV RNA检测[point-of-care XpertⓇHCV病毒载量指尖针刺（60分钟结果）或干血斑（DBS）（1-2周）]。先前没有HCV感染的参与者接受自我注射INSTIⓇHCV抗体（1分钟），工作人员辅助INSTIⓇHCV抗体（1分钟），工作人员辅助BiolineⓇHCV抗体（5-20分钟）和HCV RNA检测。参与者完成了他们喜欢的测试，一项调查，并获得了20澳元的报销。逻辑回归评估了在有或没有HCV感染的患者中倾向于进行即时RNA检测的相关因素。结果共纳入404例，其中女性占27%，曾注射过毒品者占75%。在有HCV病史的患者（n=129）中，91% （n=117）的患者选择即时RNA检测，主要原因是检测时间短（52%）和希望今天就知道RNA检测结果（21%）。在没有HCV病史的患者中（n=275）， 72% （n=199）选择工作人员辅助的INSTIⓇ抗体检测，19% （n=51）选择护理点RNA检测，4% （n=10）选择自行进行INSTIⓇ抗体检测。选择人员辅助INSTIⓇ的主要原因包括到结果时间短（75%）和门诊时间短（8%）。在没有先前感染的患者中选择护理点RNA检测的相关因素包括近期注射吸毒、无家可归和近期阿片类激动剂治疗。结论：研究结果强调了提供快速的、工作人员辅助的HCV检测对提高高危人群的接受度的重要性。

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Patient preferences for simplified hepatitis C testing modalities among people at risk of hepatitis C infection in Australia: the SELECT study

Background

Understanding patient preferences for hepatitis C virus (HCV) testing is essential to improve uptake and support elimination efforts. Despite innovative testing modalities, limited research examines how preferences influence testing choices. This study compared the uptake of HCV testing modalities when participants were given a choice.

Methods

People at risk of HCV were recruited from community sites in the Australian Hepatitis C Point-of-Care Testing Program. Participants used a visual aid outlining test features, including time to result and collection methods. Those reporting prior HCV infection were offered staff-assisted HCV RNA tests [point-of-care Xpert^Ⓡ HCV Viral Load Fingerstick (result in 60 min) or dried blood spot (DBS) (1–2 weeks)]. Participants without prior HCV infection were offered self-administered INSTI^Ⓡ HCV antibody (1 min), staff-assisted INSTI^Ⓡ HCV antibody (1 min), staff-assisted Bioline^Ⓡ HCV antibody (5–20 min), and HCV RNA tests. Participants completed their preferred test, a survey, and received AUD$20 reimbursement. Logistic regression evaluated factors associated with preference for point-of-care RNA testing in those with and without prior HCV infection.

Results

404 people were enrolled (27% female, 75% ever injected drugs). Among those with a history of HCV (n=129), 91% (n=117) selected point-of-care RNA testing and cited the short time to result (52%) and wanting to find out the RNA result today (21%) as key reasons. Among those without a history of HCV (n=275), 72% (n=199) selected staff-assisted INSTI^Ⓡ antibody testing, 19% (n=51) selected point-of-care RNA testing, and 4% (n=10) chose self-administered INSTI^Ⓡ antibody testing. Key reasons for selecting staff-assisted INSTI^Ⓡ included short time to result (75%) and reduced clinic time (8%). Factors associated with selecting point-of-care RNA testing among those without prior infection included recent injecting drug use, homelessness and recent opioid agonist therapy.

Conclusion

Findings highlight the importance of offering rapid, staff-assisted HCV testing to improve uptake among at-risk populations.

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来源期刊

International Journal of Drug Policy SUBSTANCE ABUSE-

CiteScore

7.80

自引率

11.40%

发文量

307

审稿时长

62 days

期刊介绍： The International Journal of Drug Policy provides a forum for the dissemination of current research, reviews, debate, and critical analysis on drug use and drug policy in a global context. It seeks to publish material on the social, political, legal, and health contexts of psychoactive substance use, both licit and illicit. The journal is particularly concerned to explore the effects of drug policy and practice on drug-using behaviour and its health and social consequences. It is the policy of the journal to represent a wide range of material on drug-related matters from around the world.