Boya Wu , Jianyun Cao , Wei Xiong , Yanchun Lv , Guohua Zhao , Xiaoyue Ma , Ying Zhang , Jiawei Zhang , Junguo Bu , Tao Xie , Qianjin Feng , Meiyan Huang
{"title":"对比学习和先验知识诱导特征提取网络预测胶质瘤高危复发区域","authors":"Boya Wu , Jianyun Cao , Wei Xiong , Yanchun Lv , Guohua Zhao , Xiaoyue Ma , Ying Zhang , Jiawei Zhang , Junguo Bu , Tao Xie , Qianjin Feng , Meiyan Huang","doi":"10.1016/j.media.2025.103740","DOIUrl":null,"url":null,"abstract":"<div><div>Gliomas can easily recur even after standard treatments, and their recurrence may be related to insufficient radiation doses received by high-risk recurrence areas (HRA). Therefore, HRA prediction can help clinical experts in formulating effective radiotherapy plans. However, research on HRA prediction using early postoperative conventional MRI images with total resection is lacking. This gap is due to multifold challenges, including visually minimal differences between HRA and non-HRA and small dataset size caused by missing follow-up data. A contrastive learning and prior knowledge-induced feature extraction network (CLPKnet) to explore HRA-related features and achieve HRA prediction was proposed in this paper. First, a contrastive and multisequence learning-based encoder was proposed to effectively extract diverse features across multiple MRI sequences around the operative cavity. Specifically, a contrastive learning method was employed to pretrain the encoder, which enabled it to capture subtle differences between HRA and non-HRA regions while mitigating the challenges posed by the limited dataset size. Second, clinical prior knowledge was incorporated into the CLPKnet to guide the model in learning the patterns of glioma growth and improve its discriminative capability for identifying HRA regions. Third, a dual-focus fusion module was utilized to explore important sequential features and spatial regions and effectively fused multisequence features to provide complementary information associated with glioma recurrence. Fourth, to balance clinical needs and task difficulty, we used a patch-based prediction method to predict the recurrent probability. The CLPKnet was validated on a multicenter dataset from four hospitals, and a remarkable performance was achieved. Moreover, the interpretability and robustness of our method were evaluated to illustrate its effectiveness and credibility. Therefore, the CLPKnet displays a great application potential for HRA prediction. The codes will be available at <span><span>https://github.com/Meiyan88/CLPKnet</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":18328,"journal":{"name":"Medical image analysis","volume":"107 ","pages":"Article 103740"},"PeriodicalIF":11.8000,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Contrastive learning and prior knowledge-induced feature extraction network for prediction of high-risk recurrence areas in Gliomas\",\"authors\":\"Boya Wu , Jianyun Cao , Wei Xiong , Yanchun Lv , Guohua Zhao , Xiaoyue Ma , Ying Zhang , Jiawei Zhang , Junguo Bu , Tao Xie , Qianjin Feng , Meiyan Huang\",\"doi\":\"10.1016/j.media.2025.103740\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Gliomas can easily recur even after standard treatments, and their recurrence may be related to insufficient radiation doses received by high-risk recurrence areas (HRA). Therefore, HRA prediction can help clinical experts in formulating effective radiotherapy plans. However, research on HRA prediction using early postoperative conventional MRI images with total resection is lacking. This gap is due to multifold challenges, including visually minimal differences between HRA and non-HRA and small dataset size caused by missing follow-up data. A contrastive learning and prior knowledge-induced feature extraction network (CLPKnet) to explore HRA-related features and achieve HRA prediction was proposed in this paper. First, a contrastive and multisequence learning-based encoder was proposed to effectively extract diverse features across multiple MRI sequences around the operative cavity. Specifically, a contrastive learning method was employed to pretrain the encoder, which enabled it to capture subtle differences between HRA and non-HRA regions while mitigating the challenges posed by the limited dataset size. Second, clinical prior knowledge was incorporated into the CLPKnet to guide the model in learning the patterns of glioma growth and improve its discriminative capability for identifying HRA regions. Third, a dual-focus fusion module was utilized to explore important sequential features and spatial regions and effectively fused multisequence features to provide complementary information associated with glioma recurrence. Fourth, to balance clinical needs and task difficulty, we used a patch-based prediction method to predict the recurrent probability. The CLPKnet was validated on a multicenter dataset from four hospitals, and a remarkable performance was achieved. Moreover, the interpretability and robustness of our method were evaluated to illustrate its effectiveness and credibility. Therefore, the CLPKnet displays a great application potential for HRA prediction. The codes will be available at <span><span>https://github.com/Meiyan88/CLPKnet</span><svg><path></path></svg></span>.</div></div>\",\"PeriodicalId\":18328,\"journal\":{\"name\":\"Medical image analysis\",\"volume\":\"107 \",\"pages\":\"Article 103740\"},\"PeriodicalIF\":11.8000,\"publicationDate\":\"2025-08-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Medical image analysis\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1361841525002877\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medical image analysis","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1361841525002877","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE","Score":null,"Total":0}
Contrastive learning and prior knowledge-induced feature extraction network for prediction of high-risk recurrence areas in Gliomas
Gliomas can easily recur even after standard treatments, and their recurrence may be related to insufficient radiation doses received by high-risk recurrence areas (HRA). Therefore, HRA prediction can help clinical experts in formulating effective radiotherapy plans. However, research on HRA prediction using early postoperative conventional MRI images with total resection is lacking. This gap is due to multifold challenges, including visually minimal differences between HRA and non-HRA and small dataset size caused by missing follow-up data. A contrastive learning and prior knowledge-induced feature extraction network (CLPKnet) to explore HRA-related features and achieve HRA prediction was proposed in this paper. First, a contrastive and multisequence learning-based encoder was proposed to effectively extract diverse features across multiple MRI sequences around the operative cavity. Specifically, a contrastive learning method was employed to pretrain the encoder, which enabled it to capture subtle differences between HRA and non-HRA regions while mitigating the challenges posed by the limited dataset size. Second, clinical prior knowledge was incorporated into the CLPKnet to guide the model in learning the patterns of glioma growth and improve its discriminative capability for identifying HRA regions. Third, a dual-focus fusion module was utilized to explore important sequential features and spatial regions and effectively fused multisequence features to provide complementary information associated with glioma recurrence. Fourth, to balance clinical needs and task difficulty, we used a patch-based prediction method to predict the recurrent probability. The CLPKnet was validated on a multicenter dataset from four hospitals, and a remarkable performance was achieved. Moreover, the interpretability and robustness of our method were evaluated to illustrate its effectiveness and credibility. Therefore, the CLPKnet displays a great application potential for HRA prediction. The codes will be available at https://github.com/Meiyan88/CLPKnet.
期刊介绍:
Medical Image Analysis serves as a platform for sharing new research findings in the realm of medical and biological image analysis, with a focus on applications of computer vision, virtual reality, and robotics to biomedical imaging challenges. The journal prioritizes the publication of high-quality, original papers contributing to the fundamental science of processing, analyzing, and utilizing medical and biological images. It welcomes approaches utilizing biomedical image datasets across all spatial scales, from molecular/cellular imaging to tissue/organ imaging.