龙血龙血素A和（±）-新龙血龙黄酮A、三萜和类黄酮具有抗炎活性。

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-08-05 DOI:10.1021/acs.orglett.5c02756

Wei Li, Yanfu Wang, Jinchang Liu, Yinglin Zheng, Xiongyi Zhang, Jingxin Liu, Junping Pei, Xiaoyun Lu, Weihuan Huang*, Renwang Jiang* and Haiyan Tian*,

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引用次数: 0

摘要

从龙血树（Dracaena cochinensis）的树脂木中分离到一种具有断裂的C环和内酯化的D环的三萜化合物Lanosdracaenin A(1)和一对重排的类黄酮（±）- neodracafavonoids A[（±）-2]。这些化合物的绝对构型由核磁共振波谱、ECD计算和x射线晶体学确定。所有化合物在斑马鱼模型和lps刺激的RAW264.7细胞中均表现出显著的抗炎作用，并抑制炎症相关基因IL-1β和IL-6的表达。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Lanosdracaenin A and (±)-Neodracaflavonoids A, Triterpenoid and Flavonoids with Anti-Inflammatory Activities from Dracaena cochinchinensis

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Lanosdracaenin A and (±)-Neodracaflavonoids A, Triterpenoid and Flavonoids with Anti-Inflammatory Activities from Dracaena cochinchinensis

Lanosdracaenin A (1), an unprecedented triterpenoid, featuring a cleaved C ring and a lactonized D ring, and (±)-neodracaflavonoids A [(±)-2], a pair of rearranged flavonoids, were isolated from the resinous wood of Dracaena cochinchinensi. The absolute configurations of these compounds were determined by NMR spectroscopy, ECD calculations, and X-ray crystallography. All compounds exhibited significant anti-inflammatory effects in zebrafish model and LPS-stimulated RAW264.7 cells and suppressed the expression of the inflammation related genes IL-1β and IL-6.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.