关于药物风险的宣传内容和传播如何影响开处方者的意识、知识和行为:一项系统综述。

IF 3.8 2区 医学 Q1 PHARMACOLOGY & PHARMACY
Lucy T Perry, Annim Mohammad, Ashleigh Hooimeyer, Eliza J McEwin, Barbara Mintzes
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引用次数: 0

摘要

背景:药物具有重要的,有时甚至可以挽救生命的健康益处。它们也可能是由于药物不良反应(adr)造成伤害和伤害的原因。药物风险的有效沟通对于明智的处方决定和保护患者健康至关重要。临床医生必须接收、解释并实施这些信息,以达到预期的效果;然而,这并不总是成功的。因此,了解药物风险沟通的内容和传播方法如何影响开处方者的意识、知识和行为是很重要的。目的:本系统评价概述了药物风险通报的内容和传播对处方者的意识、知识和行为以及最终对患者健康的影响。方法:进行系统评价。如果研究是随机对照试验,调查药物风险宣传的内容或传播对处方者的知识、意识和行为的影响,则纳入研究。通过Ovid, Scopus和Web of Science数据库检索到2024年12月的MEDLINE, Embase和PsycINFO。提取有关干预类型、研究设计、处方类型和结果的数据。综合结果,并在结果允许的情况下进行荟萃分析。结果:23项研究符合纳入标准,其中10项研究调查风险沟通内容,10项研究调查传播方式,3项研究同时调查风险沟通内容和传播方式。21项研究评估处方行为,各有一项研究评估临床医生的意识和知识。两项研究评估了风险沟通内容及其向临床医生的传递如何影响患者的健康结果。干预措施包括计算机化临床系统、风险评估工具、警报系统、有针对性的信息传递和教育。可视化风险评估工具和有针对性的教育降低了不良反应发生率,改善了患者健康。警示改变临床监测和评估行为的效果中等(相对危险度[RR] 1.03;95%可信区间[CI] 1.01-1.05)。多组分方法也对处方行为产生积极影响。有针对性的信息,如审计和反馈,提高了临床医生对风险沟通的认识。计算机警报和风险评估具有中断性,易于在工作流程中访问,或提供避免或最小化患者风险的行动或信息,但没有显著改变处方(RR 1.50;95% CI 0.87-2.60, RR 1.41;95% ci 0.89-2.24)。然而,研究异质性和小样本量限制了检测差异的能力。结论:比较针对处方者的药物风险沟通策略有效性的随机对照试验证据有限。没有一项内容或传播干预是完全有效的;然而,确定了风险沟通内容及其向临床医生传播的关键方面,包括多模式方法。有必要进一步调查。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
How does the Content and Dissemination of Communications on the Risks of Medicines Affect Prescriber Awareness, Knowledge, and Behaviour: A Systematic Review.

Background: Medicines have important and sometimes lifesaving health benefits. They can also be the cause of harm and injury due to adverse drug reactions (ADRs). Effective communication of medicine risks is crucial to informed prescribing decisions and the protection of patient health. Clinicians must receive, interpret, and then implement these communications to achieve desired outcomes; however, this has not always been successful. Therefore, it is important to understand how the content of risk communication about medicines and the methods of dissemination may affect prescribers' awareness, knowledge, and behaviours.

Aims: This systematic review provides an overview of the effect of content and dissemination of risk communications about medicines on prescribers' awareness, knowledge, and behaviour and ultimately on patient health.

Methods: A systematic review was conducted. Studies were included if they were randomised controlled trials investigating the effect of the content or dissemination of risk communications about medicines on prescribers' knowledge, awareness, and behaviour. MEDLINE, Embase, and PsycINFO via Ovid, Scopus, and Web of Science databases were searched up to December 2024. Data on intervention type, study design, prescriber type, and outcomes were extracted. Outcomes were synthesised, and meta-analysis was undertaken where results allowed for this.

Results: Twenty-three studies met the inclusion criteria: ten investigated the content of risk communication, ten investigated dissemination methods, and three investigated both. Twenty-one studies assessed prescribing behaviours, and one study each assessed clinicians' awareness and knowledge, respectively. Two studies evaluated how risk communication content and its delivery to clinicians affected patient health outcomes. Interventions included computerised clinical systems, risk assessment tools, alerting systems, targeted messaging, and education. Visual risk assessment tools and targeted education reduced ADR rates, improving patient health. Alerts to change clinical monitoring and assessment behaviour were modestly effective (relative risk [RR] 1.03; 95% confidence interval [CI] 1.01-1.05). Multicomponent approaches also positively affected prescribing behaviours. Targeted messages, such as audit and feedback, improved clinicians' awareness of risk communications. Computer alerts and risk assessments that were interruptive and easily accessed in workflows or provided actions or information to avoid or minimise risk to patients did not significantly change prescribing (RR 1.50; 95% CI 0.87-2.60 and RR 1.41; 95% CI 0.89-2.24). However, study heterogeneity and small sample sizes limited the power to detect differences.

Conclusion: There is limited evidence from randomised controlled trials comparing the effectiveness of drug risk communication strategies targeting prescribers. No one content or dissemination intervention was wholly effective; however, key aspects of risk communication content and its dissemination to clinicians were identified, including multi-modal approaches. Further investigation is warranted.

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来源期刊
Drug Safety
Drug Safety 医学-毒理学
CiteScore
7.60
自引率
7.10%
发文量
112
审稿时长
6-12 weeks
期刊介绍: Drug Safety is the official journal of the International Society of Pharmacovigilance. The journal includes: Overviews of contentious or emerging issues. Comprehensive narrative reviews that provide an authoritative source of information on epidemiology, clinical features, prevention and management of adverse effects of individual drugs and drug classes. In-depth benefit-risk assessment of adverse effect and efficacy data for a drug in a defined therapeutic area. Systematic reviews (with or without meta-analyses) that collate empirical evidence to answer a specific research question, using explicit, systematic methods as outlined by the PRISMA statement. Original research articles reporting the results of well-designed studies in disciplines such as pharmacoepidemiology, pharmacovigilance, pharmacology and toxicology, and pharmacogenomics. Editorials and commentaries on topical issues. Additional digital features (including animated abstracts, video abstracts, slide decks, audio slides, instructional videos, infographics, podcasts and animations) can be published with articles; these are designed to increase the visibility, readership and educational value of the journal’s content. In addition, articles published in Drug Safety Drugs may be accompanied by plain language summaries to assist readers who have some knowledge of, but not in-depth expertise in, the area to understand important medical advances.
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