Shalmali Dharmadhikari, Nicolas Muñoz, Emily Vail, Peter Abt
{"title":"美国用于研究的实体器官采购趋势","authors":"Shalmali Dharmadhikari, Nicolas Muñoz, Emily Vail, Peter Abt","doi":"10.1111/ctr.70267","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>To examine national trends and regional variability in the procurement of solid organs recovered for research from deceased donors in the United States.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>A retrospective cohort study of the Organ Procurement and Transplantation Network (OPTN)/United Network for Organ Sharing (UNOS) deceased donor registry data was conducted, including all deceased donors who underwent surgery for organ recovery from April 2015 to December 2023. The study classified each donated organ (liver, heart, pancreas, lung, kidney, and intestine) into four categories: not recovered, recovered for transplant, recovered for research, recovered for other purposes/discarded, with a focus on organs recovered for research.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Among 107,485 deceased organ donors across 58 organ procurement organizations (OPOs), organs recovered for research included 2491 intestines, 6494 hearts, 6627 livers, 9098 kidneys, 10,711 pancreata, and 13,025 lungs. Research organ recovery showed an upward trend, particularly for pancreata. Median percentage of organ recovery for research across the OPOs, varied significantly by organ type: intestines (65.4%), pancreata (36.1%), lungs (28.3%), heart (11.3%), liver (7.1%), and kidneys (3.8%), with no significant correlation between OPO donor organ volumes and research organ recovery rates. Analysis of the 2021 data showed a higher median percentage of research organ recovery in Tier 1 OPOs (13.8%) compared to Tier 2 (10.8%) and Tier 3 (11.4%), though these differences were not statistically significant (<i>p</i> = 0.18).</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Given the opacity of existing practices and unrealized potential of research organs, our findings warrant the need for improved surveillance, centralized tracking, and a robust framework for research organ recovery.</p>\n </section>\n </div>","PeriodicalId":10467,"journal":{"name":"Clinical Transplantation","volume":"39 8","pages":""},"PeriodicalIF":1.9000,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"United States Trends in Procurement of Solid Organs Intended for Research\",\"authors\":\"Shalmali Dharmadhikari, Nicolas Muñoz, Emily Vail, Peter Abt\",\"doi\":\"10.1111/ctr.70267\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>To examine national trends and regional variability in the procurement of solid organs recovered for research from deceased donors in the United States.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>A retrospective cohort study of the Organ Procurement and Transplantation Network (OPTN)/United Network for Organ Sharing (UNOS) deceased donor registry data was conducted, including all deceased donors who underwent surgery for organ recovery from April 2015 to December 2023. The study classified each donated organ (liver, heart, pancreas, lung, kidney, and intestine) into four categories: not recovered, recovered for transplant, recovered for research, recovered for other purposes/discarded, with a focus on organs recovered for research.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Among 107,485 deceased organ donors across 58 organ procurement organizations (OPOs), organs recovered for research included 2491 intestines, 6494 hearts, 6627 livers, 9098 kidneys, 10,711 pancreata, and 13,025 lungs. Research organ recovery showed an upward trend, particularly for pancreata. Median percentage of organ recovery for research across the OPOs, varied significantly by organ type: intestines (65.4%), pancreata (36.1%), lungs (28.3%), heart (11.3%), liver (7.1%), and kidneys (3.8%), with no significant correlation between OPO donor organ volumes and research organ recovery rates. Analysis of the 2021 data showed a higher median percentage of research organ recovery in Tier 1 OPOs (13.8%) compared to Tier 2 (10.8%) and Tier 3 (11.4%), though these differences were not statistically significant (<i>p</i> = 0.18).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>Given the opacity of existing practices and unrealized potential of research organs, our findings warrant the need for improved surveillance, centralized tracking, and a robust framework for research organ recovery.</p>\\n </section>\\n </div>\",\"PeriodicalId\":10467,\"journal\":{\"name\":\"Clinical Transplantation\",\"volume\":\"39 8\",\"pages\":\"\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-08-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Transplantation\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/ctr.70267\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"SURGERY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Transplantation","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/ctr.70267","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"SURGERY","Score":null,"Total":0}
United States Trends in Procurement of Solid Organs Intended for Research
Background
To examine national trends and regional variability in the procurement of solid organs recovered for research from deceased donors in the United States.
Methods
A retrospective cohort study of the Organ Procurement and Transplantation Network (OPTN)/United Network for Organ Sharing (UNOS) deceased donor registry data was conducted, including all deceased donors who underwent surgery for organ recovery from April 2015 to December 2023. The study classified each donated organ (liver, heart, pancreas, lung, kidney, and intestine) into four categories: not recovered, recovered for transplant, recovered for research, recovered for other purposes/discarded, with a focus on organs recovered for research.
Results
Among 107,485 deceased organ donors across 58 organ procurement organizations (OPOs), organs recovered for research included 2491 intestines, 6494 hearts, 6627 livers, 9098 kidneys, 10,711 pancreata, and 13,025 lungs. Research organ recovery showed an upward trend, particularly for pancreata. Median percentage of organ recovery for research across the OPOs, varied significantly by organ type: intestines (65.4%), pancreata (36.1%), lungs (28.3%), heart (11.3%), liver (7.1%), and kidneys (3.8%), with no significant correlation between OPO donor organ volumes and research organ recovery rates. Analysis of the 2021 data showed a higher median percentage of research organ recovery in Tier 1 OPOs (13.8%) compared to Tier 2 (10.8%) and Tier 3 (11.4%), though these differences were not statistically significant (p = 0.18).
Conclusion
Given the opacity of existing practices and unrealized potential of research organs, our findings warrant the need for improved surveillance, centralized tracking, and a robust framework for research organ recovery.
期刊介绍：
Clinical Transplantation: The Journal of Clinical and Translational Research aims to serve as a channel of rapid communication for all those involved in the care of patients who require, or have had, organ or tissue transplants, including: kidney, intestine, liver, pancreas, islets, heart, heart valves, lung, bone marrow, cornea, skin, bone, and cartilage, viable or stored.
Published monthly, Clinical Transplantation’s scope is focused on the complete spectrum of present transplant therapies, as well as also those that are experimental or may become possible in future. Topics include:
Immunology and immunosuppression;
Patient preparation;
Social, ethical, and psychological issues;
Complications, short- and long-term results;
Artificial organs;
Donation and preservation of organ and tissue;
Translational studies;
Advances in tissue typing;
Updates on transplant pathology;.
Clinical and translational studies are particularly welcome, as well as focused reviews. Full-length papers and short communications are invited. Clinical reviews are encouraged, as well as seminal papers in basic science which might lead to immediate clinical application. Prominence is regularly given to the results of cooperative surveys conducted by the organ and tissue transplant registries.
Clinical Transplantation: The Journal of Clinical and Translational Research is essential reading for clinicians and researchers in the diverse field of transplantation: surgeons; clinical immunologists; cryobiologists; hematologists; gastroenterologists; hepatologists; pulmonologists; nephrologists; cardiologists; and endocrinologists. It will also be of interest to sociologists, psychologists, research workers, and to all health professionals whose combined efforts will improve the prognosis of transplant recipients.
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