DNA损伤反应和细胞命运决定贯穿整个生命周期:从胎儿发育到年龄相关的呼吸系统疾病。

IF 6.2 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Xuewei Cui, Ye Wang, Jianhua Fu
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引用次数: 0

摘要

DNA是一种重要的遗传物质,其完整性和稳定性需要维持正常的细胞功能、生长和发育。DNA损伤反应(DDR)构成了一个复杂、精密和广泛的信号网络,在压力下保持基因组的稳定性。它可以分为DNA损伤监测系统和DNA损伤修复系统,它们协同工作以确保基因组的完整性。当DNA损伤超过DDR的修复能力时,未修复的DNA损伤积累,诱导细胞衰老并改变肺泡上皮细胞的命运;这一过程与发育性和慢性肺部疾病的发病、进展和管理有着复杂的联系。本文综述了DDR在支气管肺发育不良、支气管哮喘、慢性阻塞性肺疾病、特发性肺纤维化等呼吸系统疾病中发病机制的最新研究进展,以及相关靶向治疗策略的发展进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

DNA damage response and cell fate decisions across the lifespan: from fetal development to age-related respiratory diseases.

DNA damage response and cell fate decisions across the lifespan: from fetal development to age-related respiratory diseases.

DNA damage response and cell fate decisions across the lifespan: from fetal development to age-related respiratory diseases.

DNA damage response and cell fate decisions across the lifespan: from fetal development to age-related respiratory diseases.

The integrity and stability of DNA, an essential genetic material, need to be maintained for normal cellular function, growth, and development. The DNA damage response (DDR) constitutes a complex, sophisticated, and extensive signaling network that preserves genomic stability under stress. It can be divided into the DNA damage surveillance system and DNA damage repair system, which work in concert to ensure genomic integrity. When DNA damage surpasses the repair capacity of the DDR, unrepaired DNA damage accumulates, inducing cellular senescence and altering the fate of alveolar epithelial cells; this process is intricately linked to the onset, progression, and management of developmental and chronic lung diseases. In this review, recent research on the pathogenic mechanisms of DDR in respiratory diseases across the lifespan, including bronchopulmonary dysplasia, bronchial asthma, chronic obstructive pulmonary disease, and idiopathic pulmonary fibrosis, as well as progress in the development of associated targeted therapeutic strategies, is synthesized.

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来源期刊
Cell and Bioscience
Cell and Bioscience BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
10.70
自引率
0.00%
发文量
187
审稿时长
>12 weeks
期刊介绍: Cell and Bioscience, the official journal of the Society of Chinese Bioscientists in America, is an open access, peer-reviewed journal that encompasses all areas of life science research.
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