超越G蛋白和阻滞蛋白：grk2偏倚的β 2 AR信号。

IF 19.9 1区医学 Q1 PHARMACOLOGY & PHARMACY

Trends in pharmacological sciences Pub Date : 2025-10-01 Epub Date: 2025-08-01 DOI:10.1016/j.tips.2025.07.010

Ren-Lei Ji, Zhe Wang, Jean J Zhao

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引用次数: 0

摘要

偏置g蛋白偶联受体（GPCR）信号通过通路选择性药物作用重塑药物发现。Motso等人最近的研究发现，GPCR激酶2 （GRK2）是一种非规范的传感器，独立于G蛋白或β-阻滞蛋白，重新定义了有偏的信号传导领域，并强调了GRK2作为GPCR驱动的代谢反应选择性调节的新治疗靶点。

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Beyond G protein and arrestin: GRK2-biased β₂AR signaling.

Biased G-protein-coupled receptor (GPCR) signaling is reshaping drug discovery by enabling pathway-selective drug action. Recent work by Motso et al. identified GPCR kinase 2 (GRK2) as a non-canonical transducer, independent of G proteins or β-arrestins, redefining the biased signaling landscape and highlighting GRK2 as a novel therapeutic target for selective modulation of GPCR-driven metabolic responses.

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来源期刊

Trends in pharmacological sciences 医学-药学

CiteScore

23.90

自引率

0.70%

发文量

132

审稿时长

6-12 weeks

期刊介绍： Trends in Pharmacological Sciences (TIPS) is a monthly peer-reviewed reviews journal that focuses on a wide range of topics in pharmacology, pharmacy, pharmaceutics, and toxicology. Launched in 1979, TIPS publishes concise articles discussing the latest advancements in pharmacology and therapeutics research. The journal encourages submissions that align with its core themes while also being open to articles on the biopharma regulatory landscape, science policy and regulation, and bioethics. Each issue of TIPS provides a platform for experts to share their insights and perspectives on the most exciting developments in the field. Through rigorous peer review, the journal ensures the quality and reliability of published articles. Authors are invited to contribute articles that contribute to the understanding of pharmacology and its applications in various domains. Whether it's exploring innovative drug therapies or discussing the ethical considerations of pharmaceutical research, TIPS provides a valuable resource for researchers, practitioners, and policymakers in the pharmacological sciences.