胰腺癌的线粒体中心脂质代谢和细胞器间串扰：揭示新的治疗方法。

IF 10.1 1区医学 Q1 ONCOLOGY

Cancer letters Pub Date : 2025-08-05 DOI:10.1016/j.canlet.2025.217965

Runxian Wang , Changhao Gao , Zhiyao Fan , Qingdi Qin, Hanxiang Zhan

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引用次数: 0

摘要

胰腺癌是一种侵袭性恶性肿瘤，常规治疗效果不佳，部分原因是其独特的增殖和耐药性。本文综述了胰腺癌细胞的脂质代谢，重点介绍了线粒体与其他细胞器之间的串扰。强调了细胞膜、内质网、脂滴和线粒体在脂质转运和代谢中的重要性，它们对胰腺癌抗化疗的能量补充和细胞结构至关重要。这篇综述还讨论了这些细胞器如何相互作用以支持恶性肿瘤，并表明针对不同细胞器的脂质代谢调节药物可以克服吉西他滨等治疗的耐药性。此外，它指出了线粒体和其他细胞器在胰腺癌PD-L1调节中的作用，表明了新的治疗策略的潜力。

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Mitochondria-centric lipid metabolism and inter-organelle crosstalk in pancreatic Cancer: Unveiling novel therapies

Pancreatic cancer is an aggressive malignancy with poor therapeutic responses to conventional treatments, partly due to its unique proliferation and drug resistance. This review focuses on the lipid metabolism in pancreatic cancer cells, emphasizing the crosstalk between mitochondria and other organelles. It highlights the importance of cellular membranes, endoplasmic reticulum, lipid droplets, and mitochondria in lipid transportation and metabolism, which are crucial for energy supplementation and cell structure to resist chemotherapy in pancreatic cancer. The review also discusses how these organelles interact to support the malignancy and suggests that lipid metabolism-regulating drugs targeting different organelles could overcome the resistance of treatments like gemcitabine. Moreover, it points out the role of mitochondrial and other organelles in the PD-L1 regulation of pancreatic cancer, indicating potential for novel therapeutic strategies.

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来源期刊

Cancer letters 医学-肿瘤学

CiteScore

17.70

自引率

2.10%

发文量

427

审稿时长

15 days

期刊介绍： Cancer Letters is a reputable international journal that serves as a platform for significant and original contributions in cancer research. The journal welcomes both full-length articles and Mini Reviews in the wide-ranging field of basic and translational oncology. Furthermore, it frequently presents Special Issues that shed light on current and topical areas in cancer research. Cancer Letters is highly interested in various fundamental aspects that can cater to a diverse readership. These areas include the molecular genetics and cell biology of cancer, radiation biology, molecular pathology, hormones and cancer, viral oncology, metastasis, and chemoprevention. The journal actively focuses on experimental therapeutics, particularly the advancement of targeted therapies for personalized cancer medicine, such as metronomic chemotherapy. By publishing groundbreaking research and promoting advancements in cancer treatments, Cancer Letters aims to actively contribute to the fight against cancer and the improvement of patient outcomes.