{"title":"磷脂酰丝氨酸通过调节胆汁酸代谢和肠道微生物群改善高脂肪饮食诱导的肥胖","authors":"Longgang Jia, Ruijia Wang, Wanbo Lu, Hui Sun, Zhiqi Huang, Hongbin Wang, Fuping Lu, Yihan Liu","doi":"10.1111/1750-3841.70335","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>Obesity has emerged as a prevalent clinical and public health concern in contemporary society, imposing significant economic and social burdens worldwide. Phosphatidylserine (PS), a functionally diverse phospholipid, demonstrates multiple biological activities. This study delves into the efficacy and underlying mechanisms of PS in mitigating high-fat diet (HFD)-induced obesity in mice. Comprehensive physiological and biochemical assessments revealed that both preventive and therapeutic interventions with PS effectively attenuated lipid accumulation, liver dysfunction, and obesity associated with HFD consumption. Metabolomic analyses further illuminated that HFD mice hepatic cholic acid (CA), β-muricholic acid (β-MCA), and deoxycholic acid (DCA) contents were significantly decreased by 42.5%–58.5%, 66.4%–69.0%, and 11.0%–12.2%, respectively, after PS administration. And serum α-muricholic acid (α-MCA) and ω-muricholic acid (ω-MCA) were also significantly reduced by 19.2%–23.4% and 9.3%–11.5%, respectively. 16S rDNA sequencing highlighted the modulatory effects of PS on gut microbiota composition in HFD mice. Specifically, PS treatment positively correlated with the abundance of <i>Alloprevotella</i> and inversely correlated with <i>Parasutterella</i>, <i>Olsenella</i>, and <i>Allobaculum</i>, suggesting a targeted modulation of the gut microbial ecosystem. In summary, this study highlights the therapeutic potential of PS in mitigating HFD-induced obesity through modulation of bile acid metabolism and gut microbiota composition. These findings provide a scientific foundation for further exploration of PS as a viable nutraceutical or therapeutic agent in obesity intervention strategies.</p>\n </div>","PeriodicalId":193,"journal":{"name":"Journal of Food Science","volume":"90 8","pages":""},"PeriodicalIF":3.4000,"publicationDate":"2025-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Phosphatidylserine Ameliorates High-Fat Diet-Induced Obesity Through Modulating the Bile Acid Metabolism and Gut Microbiota\",\"authors\":\"Longgang Jia, Ruijia Wang, Wanbo Lu, Hui Sun, Zhiqi Huang, Hongbin Wang, Fuping Lu, Yihan Liu\",\"doi\":\"10.1111/1750-3841.70335\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n <p>Obesity has emerged as a prevalent clinical and public health concern in contemporary society, imposing significant economic and social burdens worldwide. Phosphatidylserine (PS), a functionally diverse phospholipid, demonstrates multiple biological activities. This study delves into the efficacy and underlying mechanisms of PS in mitigating high-fat diet (HFD)-induced obesity in mice. Comprehensive physiological and biochemical assessments revealed that both preventive and therapeutic interventions with PS effectively attenuated lipid accumulation, liver dysfunction, and obesity associated with HFD consumption. Metabolomic analyses further illuminated that HFD mice hepatic cholic acid (CA), β-muricholic acid (β-MCA), and deoxycholic acid (DCA) contents were significantly decreased by 42.5%–58.5%, 66.4%–69.0%, and 11.0%–12.2%, respectively, after PS administration. And serum α-muricholic acid (α-MCA) and ω-muricholic acid (ω-MCA) were also significantly reduced by 19.2%–23.4% and 9.3%–11.5%, respectively. 16S rDNA sequencing highlighted the modulatory effects of PS on gut microbiota composition in HFD mice. Specifically, PS treatment positively correlated with the abundance of <i>Alloprevotella</i> and inversely correlated with <i>Parasutterella</i>, <i>Olsenella</i>, and <i>Allobaculum</i>, suggesting a targeted modulation of the gut microbial ecosystem. In summary, this study highlights the therapeutic potential of PS in mitigating HFD-induced obesity through modulation of bile acid metabolism and gut microbiota composition. These findings provide a scientific foundation for further exploration of PS as a viable nutraceutical or therapeutic agent in obesity intervention strategies.</p>\\n </div>\",\"PeriodicalId\":193,\"journal\":{\"name\":\"Journal of Food Science\",\"volume\":\"90 8\",\"pages\":\"\"},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2025-08-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Food Science\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://ift.onlinelibrary.wiley.com/doi/10.1111/1750-3841.70335\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"FOOD SCIENCE & TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Food Science","FirstCategoryId":"97","ListUrlMain":"https://ift.onlinelibrary.wiley.com/doi/10.1111/1750-3841.70335","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}
Phosphatidylserine Ameliorates High-Fat Diet-Induced Obesity Through Modulating the Bile Acid Metabolism and Gut Microbiota
Obesity has emerged as a prevalent clinical and public health concern in contemporary society, imposing significant economic and social burdens worldwide. Phosphatidylserine (PS), a functionally diverse phospholipid, demonstrates multiple biological activities. This study delves into the efficacy and underlying mechanisms of PS in mitigating high-fat diet (HFD)-induced obesity in mice. Comprehensive physiological and biochemical assessments revealed that both preventive and therapeutic interventions with PS effectively attenuated lipid accumulation, liver dysfunction, and obesity associated with HFD consumption. Metabolomic analyses further illuminated that HFD mice hepatic cholic acid (CA), β-muricholic acid (β-MCA), and deoxycholic acid (DCA) contents were significantly decreased by 42.5%–58.5%, 66.4%–69.0%, and 11.0%–12.2%, respectively, after PS administration. And serum α-muricholic acid (α-MCA) and ω-muricholic acid (ω-MCA) were also significantly reduced by 19.2%–23.4% and 9.3%–11.5%, respectively. 16S rDNA sequencing highlighted the modulatory effects of PS on gut microbiota composition in HFD mice. Specifically, PS treatment positively correlated with the abundance of Alloprevotella and inversely correlated with Parasutterella, Olsenella, and Allobaculum, suggesting a targeted modulation of the gut microbial ecosystem. In summary, this study highlights the therapeutic potential of PS in mitigating HFD-induced obesity through modulation of bile acid metabolism and gut microbiota composition. These findings provide a scientific foundation for further exploration of PS as a viable nutraceutical or therapeutic agent in obesity intervention strategies.
期刊介绍:
The goal of the Journal of Food Science is to offer scientists, researchers, and other food professionals the opportunity to share knowledge of scientific advancements in the myriad disciplines affecting their work, through a respected peer-reviewed publication. The Journal of Food Science serves as an international forum for vital research and developments in food science.
The range of topics covered in the journal include:
-Concise Reviews and Hypotheses in Food Science
-New Horizons in Food Research
-Integrated Food Science
-Food Chemistry
-Food Engineering, Materials Science, and Nanotechnology
-Food Microbiology and Safety
-Sensory and Consumer Sciences
-Health, Nutrition, and Food
-Toxicology and Chemical Food Safety
The Journal of Food Science publishes peer-reviewed articles that cover all aspects of food science, including safety and nutrition. Reviews should be 15 to 50 typewritten pages (including tables, figures, and references), should provide in-depth coverage of a narrowly defined topic, and should embody careful evaluation (weaknesses, strengths, explanation of discrepancies in results among similar studies) of all pertinent studies, so that insightful interpretations and conclusions can be presented. Hypothesis papers are especially appropriate in pioneering areas of research or important areas that are afflicted by scientific controversy.