磷脂酰丝氨酸通过调节胆汁酸代谢和肠道微生物群改善高脂肪饮食诱导的肥胖

IF 3.4 2区 农林科学 Q2 FOOD SCIENCE & TECHNOLOGY
Longgang Jia, Ruijia Wang, Wanbo Lu, Hui Sun, Zhiqi Huang, Hongbin Wang, Fuping Lu, Yihan Liu
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引用次数: 0

摘要

肥胖已成为当代社会普遍存在的临床和公共卫生问题,在世界范围内造成了重大的经济和社会负担。磷脂酰丝氨酸(PS)是一种功能多样的磷脂,具有多种生物活性。本研究探讨了甘油三酯在减轻小鼠高脂肪饮食(HFD)诱导的肥胖中的作用及其机制。综合的生理生化评估显示,PS的预防和治疗干预都能有效地减轻脂质积累、肝功能障碍和与HFD消耗相关的肥胖。代谢组学分析进一步表明,给药后HFD小鼠肝脏胆酸(CA)、β-胆酸(β-MCA)和去氧胆酸(DCA)含量分别显著降低42.5% ~ 58.5%、66.4% ~ 69.0%和11.0% ~ 12.2%。血清α-苦胆酸(α-MCA)和ω-苦胆酸(ω-MCA)也分别显著降低19.2% ~ 23.4%和9.3% ~ 11.5%。16S rDNA测序强调了PS对HFD小鼠肠道微生物群组成的调节作用。具体而言,PS处理与Alloprevotella丰度呈正相关,与Parasutterella, Olsenella和Allobaculum丰度呈负相关,表明有针对性地调节肠道微生物生态系统。综上所述,本研究强调了PS通过调节胆汁酸代谢和肠道菌群组成来减轻hfd诱导的肥胖的治疗潜力。这些发现为进一步探索PS作为一种可行的营养品或治疗药物在肥胖干预策略中的应用提供了科学基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Phosphatidylserine Ameliorates High-Fat Diet-Induced Obesity Through Modulating the Bile Acid Metabolism and Gut Microbiota

Phosphatidylserine Ameliorates High-Fat Diet-Induced Obesity Through Modulating the Bile Acid Metabolism and Gut Microbiota

Phosphatidylserine Ameliorates High-Fat Diet-Induced Obesity Through Modulating the Bile Acid Metabolism and Gut Microbiota

Phosphatidylserine Ameliorates High-Fat Diet-Induced Obesity Through Modulating the Bile Acid Metabolism and Gut Microbiota

Obesity has emerged as a prevalent clinical and public health concern in contemporary society, imposing significant economic and social burdens worldwide. Phosphatidylserine (PS), a functionally diverse phospholipid, demonstrates multiple biological activities. This study delves into the efficacy and underlying mechanisms of PS in mitigating high-fat diet (HFD)-induced obesity in mice. Comprehensive physiological and biochemical assessments revealed that both preventive and therapeutic interventions with PS effectively attenuated lipid accumulation, liver dysfunction, and obesity associated with HFD consumption. Metabolomic analyses further illuminated that HFD mice hepatic cholic acid (CA), β-muricholic acid (β-MCA), and deoxycholic acid (DCA) contents were significantly decreased by 42.5%–58.5%, 66.4%–69.0%, and 11.0%–12.2%, respectively, after PS administration. And serum α-muricholic acid (α-MCA) and ω-muricholic acid (ω-MCA) were also significantly reduced by 19.2%–23.4% and 9.3%–11.5%, respectively. 16S rDNA sequencing highlighted the modulatory effects of PS on gut microbiota composition in HFD mice. Specifically, PS treatment positively correlated with the abundance of Alloprevotella and inversely correlated with Parasutterella, Olsenella, and Allobaculum, suggesting a targeted modulation of the gut microbial ecosystem. In summary, this study highlights the therapeutic potential of PS in mitigating HFD-induced obesity through modulation of bile acid metabolism and gut microbiota composition. These findings provide a scientific foundation for further exploration of PS as a viable nutraceutical or therapeutic agent in obesity intervention strategies.

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来源期刊
Journal of Food Science
Journal of Food Science 工程技术-食品科技
CiteScore
7.10
自引率
2.60%
发文量
412
审稿时长
3.1 months
期刊介绍: The goal of the Journal of Food Science is to offer scientists, researchers, and other food professionals the opportunity to share knowledge of scientific advancements in the myriad disciplines affecting their work, through a respected peer-reviewed publication. The Journal of Food Science serves as an international forum for vital research and developments in food science. The range of topics covered in the journal include: -Concise Reviews and Hypotheses in Food Science -New Horizons in Food Research -Integrated Food Science -Food Chemistry -Food Engineering, Materials Science, and Nanotechnology -Food Microbiology and Safety -Sensory and Consumer Sciences -Health, Nutrition, and Food -Toxicology and Chemical Food Safety The Journal of Food Science publishes peer-reviewed articles that cover all aspects of food science, including safety and nutrition. Reviews should be 15 to 50 typewritten pages (including tables, figures, and references), should provide in-depth coverage of a narrowly defined topic, and should embody careful evaluation (weaknesses, strengths, explanation of discrepancies in results among similar studies) of all pertinent studies, so that insightful interpretations and conclusions can be presented. Hypothesis papers are especially appropriate in pioneering areas of research or important areas that are afflicted by scientific controversy.
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