Esraa Abdo Moustafa, Nahed Nasser Eid El-Sayed, Marwa A. Fouad, Ahmed M. El Kerdawy, Manal Abdel Fattah Ezzat, Heba Abdelrasheed Allam
{"title":"喹诺酮作为一种特殊的支架：早期经典和最近先进的合成途径，创新的神经保护潜力和结构-活性关系的简要概述","authors":"Esraa Abdo Moustafa, Nahed Nasser Eid El-Sayed, Marwa A. Fouad, Ahmed M. El Kerdawy, Manal Abdel Fattah Ezzat, Heba Abdelrasheed Allam","doi":"10.1002/ddr.70132","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>Neurodegenerative disorders represent the second largest group of diseases worldwide. 2(1<i>H</i>)-quinolone and its structural congener, 4(1<i>H</i>)-quinolone have recently become significant topics in the field of drug design and development of modulators of neurotransmitter systems and neuroprotective agents to tackle neurodegenerative disorders. In this review, the structural properties and the early classical as well as the recent novel synthetic strategies for 2(1<i>H</i>)-/4(1<i>H</i>)-quinolone are discussed. The neuropharmacological activity and mechanisms of action of several 2(1<i>H</i>)-/4(1<i>H</i>)-quinolinone-based compounds are demonstrated with special emphasis on the structure–activity relationships (SAR). Therefore, the perspectives elaborated in this review could guide medicinal chemists for rational design and development of novel 2(1<i>H</i>)-/4(1<i>H</i>)-quinolone therapeutic candidates targeting neurodegenerative diseases.</p>\n </div>","PeriodicalId":11291,"journal":{"name":"Drug Development Research","volume":"86 5","pages":""},"PeriodicalIF":4.2000,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Quinolone as a Privileged Scaffold: A Brief Overview on Early Classical and Recent Advanced Synthetic Pathways, Innovative Neuroprotective Potential, and Structure-Activity Relationships\",\"authors\":\"Esraa Abdo Moustafa, Nahed Nasser Eid El-Sayed, Marwa A. Fouad, Ahmed M. El Kerdawy, Manal Abdel Fattah Ezzat, Heba Abdelrasheed Allam\",\"doi\":\"10.1002/ddr.70132\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n <p>Neurodegenerative disorders represent the second largest group of diseases worldwide. 2(1<i>H</i>)-quinolone and its structural congener, 4(1<i>H</i>)-quinolone have recently become significant topics in the field of drug design and development of modulators of neurotransmitter systems and neuroprotective agents to tackle neurodegenerative disorders. In this review, the structural properties and the early classical as well as the recent novel synthetic strategies for 2(1<i>H</i>)-/4(1<i>H</i>)-quinolone are discussed. The neuropharmacological activity and mechanisms of action of several 2(1<i>H</i>)-/4(1<i>H</i>)-quinolinone-based compounds are demonstrated with special emphasis on the structure–activity relationships (SAR). Therefore, the perspectives elaborated in this review could guide medicinal chemists for rational design and development of novel 2(1<i>H</i>)-/4(1<i>H</i>)-quinolone therapeutic candidates targeting neurodegenerative diseases.</p>\\n </div>\",\"PeriodicalId\":11291,\"journal\":{\"name\":\"Drug Development Research\",\"volume\":\"86 5\",\"pages\":\"\"},\"PeriodicalIF\":4.2000,\"publicationDate\":\"2025-08-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Drug Development Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/ddr.70132\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug Development Research","FirstCategoryId":"3","ListUrlMain":"https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/ddr.70132","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Quinolone as a Privileged Scaffold: A Brief Overview on Early Classical and Recent Advanced Synthetic Pathways, Innovative Neuroprotective Potential, and Structure-Activity Relationships
Neurodegenerative disorders represent the second largest group of diseases worldwide. 2(1H)-quinolone and its structural congener, 4(1H)-quinolone have recently become significant topics in the field of drug design and development of modulators of neurotransmitter systems and neuroprotective agents to tackle neurodegenerative disorders. In this review, the structural properties and the early classical as well as the recent novel synthetic strategies for 2(1H)-/4(1H)-quinolone are discussed. The neuropharmacological activity and mechanisms of action of several 2(1H)-/4(1H)-quinolinone-based compounds are demonstrated with special emphasis on the structure–activity relationships (SAR). Therefore, the perspectives elaborated in this review could guide medicinal chemists for rational design and development of novel 2(1H)-/4(1H)-quinolone therapeutic candidates targeting neurodegenerative diseases.
期刊介绍：
Drug Development Research focuses on research topics related to the discovery and development of new therapeutic entities. The journal publishes original research articles on medicinal chemistry, pharmacology, biotechnology and biopharmaceuticals, toxicology, and drug delivery, formulation, and pharmacokinetics. The journal welcomes manuscripts on new compounds and technologies in all areas focused on human therapeutics, as well as global management, health care policy, and regulatory issues involving the drug discovery and development process. In addition to full-length articles, Drug Development Research publishes Brief Reports on important and timely new research findings, as well as in-depth review articles. The journal also features periodic special thematic issues devoted to specific compound classes, new technologies, and broad aspects of drug discovery and development.
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