了解细胞死亡模式和敏感性的变异性:对靶向癌症治疗的潜在影响。

IF 3.5 3区 生物学 Q3 CELL BIOLOGY
Experimental cell research Pub Date : 2025-08-01 Epub Date: 2025-07-30 DOI:10.1016/j.yexcr.2025.114688
Magdalena Wegrzyn, Malgorzata Adamiec-Organisciok, Anahit Dawicka, Daniel Fochtman, Seweryn Galecki, Ngoni Magate, Kinga Bartel, Daria Gendosz de Carrillo, Emilia Witek-Zelazny, Magdalena Skonieczna
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引用次数: 0

摘要

细胞死亡是多细胞生物个体发育过程中不可分割的机制。在每一个生物体中,组织中细胞数量的交换和调节必然存在,包括控制细胞增殖、抑制细胞周期或诱导细胞死亡途径。细胞死亡生理机制(如凋亡)的正常运作决定了体内平衡的维持,即身体的内部平衡,这直接取决于适当的pH值、渗透压或单个化合物的浓度。调节细胞死亡(RCD)在机体内稳态中起着重要作用,但如果其被破坏,并且无法控制一种或多种细胞死亡的调节,则可能导致癌症、神经变性和自身免疫性疾病等疾病。RCD有多种形式,包括细胞凋亡、坏死下垂或铁下垂。本文综述了不同肿瘤细胞系中细胞死亡的主要模式、敏感性和反应途径的可变性。了解这些动态对于优化新的治疗方式和改善癌症患者预后至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Understanding variability in cell death modes and sensitivity: Potential implications for targeted cancer therapies.

Cell death is an inseparable mechanism accompanying the individual development of multicellular organisms. In every organism, there must be a constant exchange and regulation of the number of cells in tissues, consisting of the control of their proliferation, inhibition of the cell cycle, or induction of cell death pathways. The proper functioning of the physiological mechanisms of cell death (e.g., apoptotic) determines the maintenance of homeostasis, understood as the internal balance of the body, which directly depends on the appropriate pH levels, osmotic pressure, or concentration of individual chemical compounds. Regulated cell death (RCD) plays an important role in the body's homeostasis, but in case of its disruption, and without control over the regulation of one or more types of cell death, it can cause diseases such as cancer, neurodegeneration, and autoimmune diseases. RCD can take many forms, including apoptosis, necroptosis, or ferroptosis. This review focuses the variability in dominant modes of cell death, sensitivity, and response pathways across different tumor cell lines. Understanding these dynamics is essential for optimizing novel treatment modalities and improving cancer's patient prognosis.

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来源期刊
Experimental cell research
Experimental cell research 医学-细胞生物学
CiteScore
7.20
自引率
0.00%
发文量
295
审稿时长
30 days
期刊介绍: Our scope includes but is not limited to areas such as: Chromosome biology; Chromatin and epigenetics; DNA repair; Gene regulation; Nuclear import-export; RNA processing; Non-coding RNAs; Organelle biology; The cytoskeleton; Intracellular trafficking; Cell-cell and cell-matrix interactions; Cell motility and migration; Cell proliferation; Cellular differentiation; Signal transduction; Programmed cell death.
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