{"title":"了解细胞死亡模式和敏感性的变异性:对靶向癌症治疗的潜在影响。","authors":"Magdalena Wegrzyn, Malgorzata Adamiec-Organisciok, Anahit Dawicka, Daniel Fochtman, Seweryn Galecki, Ngoni Magate, Kinga Bartel, Daria Gendosz de Carrillo, Emilia Witek-Zelazny, Magdalena Skonieczna","doi":"10.1016/j.yexcr.2025.114688","DOIUrl":null,"url":null,"abstract":"<p><p>Cell death is an inseparable mechanism accompanying the individual development of multicellular organisms. In every organism, there must be a constant exchange and regulation of the number of cells in tissues, consisting of the control of their proliferation, inhibition of the cell cycle, or induction of cell death pathways. The proper functioning of the physiological mechanisms of cell death (e.g., apoptotic) determines the maintenance of homeostasis, understood as the internal balance of the body, which directly depends on the appropriate pH levels, osmotic pressure, or concentration of individual chemical compounds. Regulated cell death (RCD) plays an important role in the body's homeostasis, but in case of its disruption, and without control over the regulation of one or more types of cell death, it can cause diseases such as cancer, neurodegeneration, and autoimmune diseases. RCD can take many forms, including apoptosis, necroptosis, or ferroptosis. This review focuses the variability in dominant modes of cell death, sensitivity, and response pathways across different tumor cell lines. Understanding these dynamics is essential for optimizing novel treatment modalities and improving cancer's patient prognosis.</p>","PeriodicalId":12227,"journal":{"name":"Experimental cell research","volume":" ","pages":"114688"},"PeriodicalIF":3.5000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Understanding variability in cell death modes and sensitivity: Potential implications for targeted cancer therapies.\",\"authors\":\"Magdalena Wegrzyn, Malgorzata Adamiec-Organisciok, Anahit Dawicka, Daniel Fochtman, Seweryn Galecki, Ngoni Magate, Kinga Bartel, Daria Gendosz de Carrillo, Emilia Witek-Zelazny, Magdalena Skonieczna\",\"doi\":\"10.1016/j.yexcr.2025.114688\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Cell death is an inseparable mechanism accompanying the individual development of multicellular organisms. In every organism, there must be a constant exchange and regulation of the number of cells in tissues, consisting of the control of their proliferation, inhibition of the cell cycle, or induction of cell death pathways. The proper functioning of the physiological mechanisms of cell death (e.g., apoptotic) determines the maintenance of homeostasis, understood as the internal balance of the body, which directly depends on the appropriate pH levels, osmotic pressure, or concentration of individual chemical compounds. Regulated cell death (RCD) plays an important role in the body's homeostasis, but in case of its disruption, and without control over the regulation of one or more types of cell death, it can cause diseases such as cancer, neurodegeneration, and autoimmune diseases. RCD can take many forms, including apoptosis, necroptosis, or ferroptosis. This review focuses the variability in dominant modes of cell death, sensitivity, and response pathways across different tumor cell lines. Understanding these dynamics is essential for optimizing novel treatment modalities and improving cancer's patient prognosis.</p>\",\"PeriodicalId\":12227,\"journal\":{\"name\":\"Experimental cell research\",\"volume\":\" \",\"pages\":\"114688\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2025-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Experimental cell research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.yexcr.2025.114688\",\"RegionNum\":3,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/7/30 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Experimental cell research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.yexcr.2025.114688","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/30 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
Understanding variability in cell death modes and sensitivity: Potential implications for targeted cancer therapies.
Cell death is an inseparable mechanism accompanying the individual development of multicellular organisms. In every organism, there must be a constant exchange and regulation of the number of cells in tissues, consisting of the control of their proliferation, inhibition of the cell cycle, or induction of cell death pathways. The proper functioning of the physiological mechanisms of cell death (e.g., apoptotic) determines the maintenance of homeostasis, understood as the internal balance of the body, which directly depends on the appropriate pH levels, osmotic pressure, or concentration of individual chemical compounds. Regulated cell death (RCD) plays an important role in the body's homeostasis, but in case of its disruption, and without control over the regulation of one or more types of cell death, it can cause diseases such as cancer, neurodegeneration, and autoimmune diseases. RCD can take many forms, including apoptosis, necroptosis, or ferroptosis. This review focuses the variability in dominant modes of cell death, sensitivity, and response pathways across different tumor cell lines. Understanding these dynamics is essential for optimizing novel treatment modalities and improving cancer's patient prognosis.
期刊介绍:
Our scope includes but is not limited to areas such as: Chromosome biology; Chromatin and epigenetics; DNA repair; Gene regulation; Nuclear import-export; RNA processing; Non-coding RNAs; Organelle biology; The cytoskeleton; Intracellular trafficking; Cell-cell and cell-matrix interactions; Cell motility and migration; Cell proliferation; Cellular differentiation; Signal transduction; Programmed cell death.