Chrono-Vax试验方案:流感疫苗接种时间对60-85岁成年人免疫反应的影响

IF 1.9 3区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
Koen Vink , Tamara M.J. Brouwers , Lisa Beckers , Debbie Smit , Martijn Vos , Teun Guichelaar , Tobias N. Bonten , Laura Kervezee , Debbie van Baarle , Jacco Wallinga
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引用次数: 0

摘要

越来越多的证据表明,接种疫苗的时间影响免疫反应,一些研究表明,在老年人中,上午接种流感疫苗比下午接种疫苗能引起更强的抗体反应。现有的试验侧重于抗体反应,对比两个时间组(上午和下午),而没有评估其他免疫参数,如t细胞反应,它们在对呼吸道病毒的免疫中也起着至关重要的作用,并可能有助于对疫苗接种的时间依赖性反应。因此,Chrono-Vax试验旨在确定流感疫苗接种时间对抗体和t细胞反应的影响,该时间窗口为09:00-17:00,以获得最佳给药时间的新见解。此外,本研究将探讨时间类型如何影响疫苗接种时间与疫苗诱导免疫反应之间的关系,并检查疫苗接种时间对疫苗接种后6个月内流感样疾病(ILI)和流感感染发生率的影响。共有440名60-85岁的成年人将被纳入试验,并在09:00至17:00之间的随机时间接种季节性流感疫苗。将在基线和接种后28天采集血样,以确定疫苗诱导的免疫反应。参与者将在接种疫苗后6个月内分别使用日记和快速诊断自我测试监测ILI症状和流感感染。因此,Chrono-Vax试验旨在确定一天中接种流感疫苗的最佳时间,从而有助于制定更有效的疫苗接种策略,并增强老年人对严重疾病的保护。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Chrono-Vax trial protocol: The effect of the time of day of influenza vaccination on immune responses in adults aged 60–85 years
Increasing evidence suggests that timing of vaccine administration affects immune responses, with some studies indicating that morning administration of the influenza vaccine elicits a stronger antibody response than afternoon vaccination in older adults. Existing trials focused on antibody responses, contrasting two time groups (morning versus afternoon), without assessing other immunological parameters, such as T-cell responses, which also play a crucial role in immunity to respiratory viruses and may contribute to the time-of-day dependent response to vaccination. Therefore, the Chrono-Vax trial aims to determine the effect of influenza vaccination timing on antibody and T-cell responses across a continuous time window from 09:00–17:00 to gain novel insights into an optimal administration time. Additionally, this study will investigate how chronotype influences the relationship between vaccination timing and vaccine-induced immune responses and examine the impact of vaccination timing on the incidence of influenza-like illness (ILI) and influenza infection up to six months post-vaccination. A total of 440 adults aged 60–85 years will be included in the trial and receive the seasonal influenza vaccine at a random time between 09:00 and 17:00. Blood samples will be collected at baseline and 28 days post-vaccination to determine vaccine-induced immune responses. ILI symptoms and influenza infection will be monitored by participants up to six months after vaccination using a diary and rapid diagnostic self-tests, respectively. As such, the Chrono-Vax trial aims to determine the optimal time of day for influenza vaccination, thereby contributing to more effective vaccination strategies and increased protection against severe disease in older adults.
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来源期刊
CiteScore
3.70
自引率
4.50%
发文量
281
审稿时长
44 days
期刊介绍: Contemporary Clinical Trials is an international peer reviewed journal that publishes manuscripts pertaining to all aspects of clinical trials, including, but not limited to, design, conduct, analysis, regulation and ethics. Manuscripts submitted should appeal to a readership drawn from disciplines including medicine, biostatistics, epidemiology, computer science, management science, behavioural science, pharmaceutical science, and bioethics. Full-length papers and short communications not exceeding 1,500 words, as well as systemic reviews of clinical trials and methodologies will be published. Perspectives/commentaries on current issues and the impact of clinical trials on the practice of medicine and health policy are also welcome.
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