{"title":"阵发性运动障碍。","authors":"Abhimanyu Mahajan","doi":"10.1212/cont.0000000000001596","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>This article summarizes the current understanding of paroxysmal movement disorders, including clinical features, pathophysiology, assessment, genetics, and treatment. It additionally discusses the intriguing overlap of these disorders with epilepsy.</p><p><strong>Latest developments: </strong>There is an expansion of the traditional genotype-phenotype correlation among paroxysmal movement disorders. A single genotype may present with many clinical presentations, and different genetic variations may present with a similar phenotype. In addition to recognizing the clinical presentation through careful history and examination, the approach to patients with paroxysmal movement disorders increasingly includes genetic testing for treatment and prognostication.</p><p><strong>Essential points: </strong>The spectrum of paroxysmal movement disorders continues to expand. Prompt and accurate recognition of the presenting syndrome can lead to effective treatment and symptomatic relief. It is imperative to recognize secondary causes of paroxysmal movement disorders. A greater understanding of shared molecular mechanisms and genetics may help to better tailor therapeutic strategies in the future.</p>","PeriodicalId":52475,"journal":{"name":"CONTINUUM Lifelong Learning in Neurology","volume":"31 4","pages":"1152-1181"},"PeriodicalIF":0.0000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Paroxysmal Movement Disorders.\",\"authors\":\"Abhimanyu Mahajan\",\"doi\":\"10.1212/cont.0000000000001596\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>This article summarizes the current understanding of paroxysmal movement disorders, including clinical features, pathophysiology, assessment, genetics, and treatment. It additionally discusses the intriguing overlap of these disorders with epilepsy.</p><p><strong>Latest developments: </strong>There is an expansion of the traditional genotype-phenotype correlation among paroxysmal movement disorders. A single genotype may present with many clinical presentations, and different genetic variations may present with a similar phenotype. In addition to recognizing the clinical presentation through careful history and examination, the approach to patients with paroxysmal movement disorders increasingly includes genetic testing for treatment and prognostication.</p><p><strong>Essential points: </strong>The spectrum of paroxysmal movement disorders continues to expand. Prompt and accurate recognition of the presenting syndrome can lead to effective treatment and symptomatic relief. It is imperative to recognize secondary causes of paroxysmal movement disorders. A greater understanding of shared molecular mechanisms and genetics may help to better tailor therapeutic strategies in the future.</p>\",\"PeriodicalId\":52475,\"journal\":{\"name\":\"CONTINUUM Lifelong Learning in Neurology\",\"volume\":\"31 4\",\"pages\":\"1152-1181\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"CONTINUUM Lifelong Learning in Neurology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1212/cont.0000000000001596\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"CONTINUUM Lifelong Learning in Neurology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1212/cont.0000000000001596","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}
Objective: This article summarizes the current understanding of paroxysmal movement disorders, including clinical features, pathophysiology, assessment, genetics, and treatment. It additionally discusses the intriguing overlap of these disorders with epilepsy.
Latest developments: There is an expansion of the traditional genotype-phenotype correlation among paroxysmal movement disorders. A single genotype may present with many clinical presentations, and different genetic variations may present with a similar phenotype. In addition to recognizing the clinical presentation through careful history and examination, the approach to patients with paroxysmal movement disorders increasingly includes genetic testing for treatment and prognostication.
Essential points: The spectrum of paroxysmal movement disorders continues to expand. Prompt and accurate recognition of the presenting syndrome can lead to effective treatment and symptomatic relief. It is imperative to recognize secondary causes of paroxysmal movement disorders. A greater understanding of shared molecular mechanisms and genetics may help to better tailor therapeutic strategies in the future.
期刊介绍：
Continue your professional development on your own schedule with Continuum: Lifelong Learning in Neurology®, the American Academy of Neurology" self-study continuing medical education publication. Six times a year you"ll learn from neurology"s experts in a convenient format for home or office. Each issue includes diagnostic and treatment outlines, clinical case studies, a topic-relevant ethics case, detailed patient management problem, and a multiple-choice self-assessment examination.
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