{"title":"路易体痴呆。","authors":"Bhavana R Patel","doi":"10.1212/cont.0000000000001604","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>This article reviews the diagnosis of dementia with Lewy bodies, the prodromal phase of dementia with Lewy bodies, and management of the disease.</p><p><strong>Latest developments: </strong>The diagnostic criteria and characterization of syndromes for prodromal dementia with Lewy bodies facilitate earlier recognition of individuals at risk of Lewy body dementia. Earlier diagnosis may prevent iatrogenic complications, guide families to seek appropriate resources, and provide an opportunity for future therapeutic interventions in the clinical prodrome. Advances in biomarkers include the detection of phosphorylated α-synuclein in cutaneous nerve fibers and the CSF α-synuclein seed amplification assay.</p><p><strong>Essential points: </strong>Dementia with Lewy bodies is a complex disease that requires an interdisciplinary approach to optimize diagnosis and management. Frequently occurring copathology, most commonly with Alzheimer disease, leads to greater cognitive decline, increased likelihood of admission to a long-term care facility, and a higher risk of mortality. Use of available biomarkers may better guide appropriate diagnosis and management.</p>","PeriodicalId":52475,"journal":{"name":"CONTINUUM Lifelong Learning in Neurology","volume":"31 4","pages":"956-978"},"PeriodicalIF":0.0000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Dementia With Lewy Bodies.\",\"authors\":\"Bhavana R Patel\",\"doi\":\"10.1212/cont.0000000000001604\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>This article reviews the diagnosis of dementia with Lewy bodies, the prodromal phase of dementia with Lewy bodies, and management of the disease.</p><p><strong>Latest developments: </strong>The diagnostic criteria and characterization of syndromes for prodromal dementia with Lewy bodies facilitate earlier recognition of individuals at risk of Lewy body dementia. Earlier diagnosis may prevent iatrogenic complications, guide families to seek appropriate resources, and provide an opportunity for future therapeutic interventions in the clinical prodrome. Advances in biomarkers include the detection of phosphorylated α-synuclein in cutaneous nerve fibers and the CSF α-synuclein seed amplification assay.</p><p><strong>Essential points: </strong>Dementia with Lewy bodies is a complex disease that requires an interdisciplinary approach to optimize diagnosis and management. Frequently occurring copathology, most commonly with Alzheimer disease, leads to greater cognitive decline, increased likelihood of admission to a long-term care facility, and a higher risk of mortality. Use of available biomarkers may better guide appropriate diagnosis and management.</p>\",\"PeriodicalId\":52475,\"journal\":{\"name\":\"CONTINUUM Lifelong Learning in Neurology\",\"volume\":\"31 4\",\"pages\":\"956-978\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"CONTINUUM Lifelong Learning in Neurology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1212/cont.0000000000001604\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"CONTINUUM Lifelong Learning in Neurology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1212/cont.0000000000001604","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}
Objective: This article reviews the diagnosis of dementia with Lewy bodies, the prodromal phase of dementia with Lewy bodies, and management of the disease.
Latest developments: The diagnostic criteria and characterization of syndromes for prodromal dementia with Lewy bodies facilitate earlier recognition of individuals at risk of Lewy body dementia. Earlier diagnosis may prevent iatrogenic complications, guide families to seek appropriate resources, and provide an opportunity for future therapeutic interventions in the clinical prodrome. Advances in biomarkers include the detection of phosphorylated α-synuclein in cutaneous nerve fibers and the CSF α-synuclein seed amplification assay.
Essential points: Dementia with Lewy bodies is a complex disease that requires an interdisciplinary approach to optimize diagnosis and management. Frequently occurring copathology, most commonly with Alzheimer disease, leads to greater cognitive decline, increased likelihood of admission to a long-term care facility, and a higher risk of mortality. Use of available biomarkers may better guide appropriate diagnosis and management.
期刊介绍:
Continue your professional development on your own schedule with Continuum: Lifelong Learning in Neurology®, the American Academy of Neurology" self-study continuing medical education publication. Six times a year you"ll learn from neurology"s experts in a convenient format for home or office. Each issue includes diagnostic and treatment outlines, clinical case studies, a topic-relevant ethics case, detailed patient management problem, and a multiple-choice self-assessment examination.