英国晚期/复发子宫内膜癌患者的真实世界回顾性观察研究
IF 3.2
Q2 ONCOLOGY
引用次数: 0
摘要
引言：子宫内膜癌（EC）缺乏可靠的真实数据（RWD）。在英国（UK），自2020年以来，基于肿瘤错配修复（MMR）状态的EC分子分类，即MMR缺陷（dMMR）或MMR精通（MMRp），已被推荐用于诊断。本研究描述了晚期/复发性EC患者的特征，记录了治疗途径，并使用英国国家卫生服务（NHS）信托基金的RWD评估了按MMR状态分层的临床结果。方法：这项回顾性观察性研究收集了2000年至2023年7个NHS信托机构的电子健康记录（EHRs）。临床结果包括总生存期（OS）和下一次治疗时间（TTNT）。结果：数据来自731例EC患者（79%晚期，21%复发）。总体而言，56.63%的患者接受了全身治疗；大多数患者在一线接受了铂类化疗（1L）。166例患者为MMR状态，其中25.30%为dMMR。总体而言，1L的TTNT中位数为1.22年（95%可信区间[CI] 1.02-1.37）。整个队列从1L开始的中位OS为1.80年（95% CI 1.59-2.16）， dMMR组为4.25年（95% CI 1.67-未达到[NR]）， MMRp组为2.36年（95% CI 2.10-2.36），未知MMR组为1.64年（95% CI 1.32-1.98）。结论：虽然解释受到样本量小的阻碍，但该分析表明MMR亚组之间的结果存在差异，强调了生物标志物检测对EC患者的重要性。MMR的历史记录较低；需要在将电子病历与生物标志物数据联系起来方面进行一致的测试和改进，以检查结果与MMR状态之间的关系。本文章由计算机程序翻译，如有差异，请以英文原文为准。
A Real-World Retrospective Observational Study of Patients with Advanced/Recurrent Endometrial Cancer Across England.
Introduction: Robust real-world data (RWD) on endometrial cancer (EC) are lacking. In the United Kingdom (UK), molecular classification of EC based on tumour mismatch repair (MMR) status, either MMR-deficient (dMMR) or MMR-proficient (MMRp), has been recommended at diagnosis since 2020. This study characterised patients with advanced/recurrent EC, documented treatment pathways and evaluated clinical outcomes stratified by MMR status using RWD from National Health Service (NHS) trusts in England.
Methods: This retrospective, observational study captured electronic health records (EHRs) from seven NHS trusts from 2000 to 2023. Clinical outcomes included overall survival (OS) and time to next treatment (TTNT).
Results: Data were retrieved from 731 patients with EC (79% advanced, 21% recurrent). Overall, 56.63% of patients received systemic treatment; most received platinum-based chemotherapy in first line (1L). MMR status was identified for 166 patients, with 25.30% being dMMR. Overall, 1L median TTNT was 1.22 years (95% confidence interval [CI] 1.02-1.37). Median OS from the start of 1L was 1.80 years (95% CI 1.59-2.16) in the whole cohort, 4.25 years (95% CI 1.67-not reached [NR]) in the dMMR group, 2.36 years (95% CI 2.10-2.36) in the MMRp group and 1.64 years (95% CI 1.32-1.98) in the unknown MMR group.
Conclusions: Although interpretation is hampered by small sample sizes, this analysis is suggestive of a difference in outcomes between MMR subgroups, underlining the importance of biomarker testing for patients with EC. Historic recording of MMR status was low; consistent testing and improvements in linking EHRs to biomarker data are needed to examine the relationship between outcomes and MMR status.
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来源期刊
Oncology and Therapy
ONCOLOGY-
CiteScore
3.40
自引率
0.00%
发文量
31
审稿时长
6 weeks
期刊介绍：
Now indexed in PubMed
Aims and Scope
Oncology and Therapy is an international, peer reviewed, rapid-publication (peer review in 2 weeks, published 3–4 weeks from acceptance) journal dedicated to the publication of high-quality pre-clinical, clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of therapeutics and interventions (including devices) across all therapeutic areas. Studies relating to diagnostics and diagnosis, pharmacoeconomics, public health, epidemiology, quality of life, and patient care, management, and education are also encouraged.
The journal is of interest to a broad audience of healthcare professionals and publishes original research, reviews, communications and letters. The journal is read by a global audience and receives submissions from all over the world. Oncology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of all scientifically and ethically sound research.
Rapid Publication
The journal’s rapid publication timelines aim for a peer review decision within 2 weeks of submission. If an article is accepted it will be published online 3-4 weeks from acceptance. These rapid timelines are achieved through the combination of a dedicated in-house editorial team, who closely manage article workflow, and an extensive Editorial and Advisory Board who assist with rapid peer review. This allows the journal to support the rapid dissemination of research, whilst still providing robust peer review. Combined with the journal’s open access model this allows for the rapid and efficient communication of the latest research and reviews, allowing the advancement of clinical therapies.
Personal Service
The journal’s dedicated in-house editorial team offer a personal “concierge service” meaning that authors will always have a personal point of contact able to update them on the status of their manuscript. The editorial team check all manuscripts to ensure that articles conform to the most recent COPE, GPP and ICMJE publishing guidelines. This supports the publication of ethically sound and transparent research. We also encourage pre-submission enquiries and are always happy to provide a confidential assessment of manuscripts.
Digital features and plain language summaries
Oncology and Therapy offers a range of additional features designed to increase the visibility, readership and educational value of the journal’s content. Each article is accompanied by key summary points, giving a time-efficient overview of the content to a wide readership. Articles may be accompanied by plain language summaries to assist readers who have some knowledge of, but not in-depth expertise in, the area to understand the scientific content and overall implications of the article. The journal also provides the option to include various types of digital features including animated abstracts, video abstracts, slide decks, audio slides, instructional videos, infographics, podcasts and animations. All additional features are peer reviewed to the same high standard as the article itself. If you consider that your paper would benefit from the inclusion of a digital feature, please let us know. Our editorial team are able to create high-quality slide decks and infographics in-house, and video abstracts through our partner Research Square, and would be happy to assist in any way we can. For further information about digital features, please contact the journal editor (see ‘Contact the Journal’ for email address), and see the ‘Guidelines for digital features and plain language summaries’ document under ‘Submission guidelines’.
Preprints
We encourage posting of preprints of primary research manuscripts on preprint servers, authors'' or institutional websites, and open communications between researchers whether on community preprint servers or preprint commenting platforms. Posting of preprints is not considered prior publication and will not jeopardize consideration in our journals.
Please see here for further information on preprint sharing: https://www.springer.com/gp/authors-editors/journal-author/journal-author-helpdesk/submission/1302#c16721550
Peer Review Process
Upon submission, manuscripts are assessed by the editorial team to ensure they fit within the aims and scope of the journal and are also checked for plagiarism. All suitable submissions are then subject to a comprehensive single-blind peer review. Reviewers are selected based on their relevant expertise and publication history in the subject area. The journal has an extensive pool of editorial and advisory board members who have been selected to assist with peer review based on the afore-mentioned criteria.
At least two extensive reviews are required to make the editorial decision, with the exception of some article types such as Commentaries, Editorials and Letters which are generally reviewed by one member of the Editorial Board. Where reviewer recommendations are conflicted, the editorial board will be contacted for further advice and a presiding decision.
Manuscripts are then either accepted, rejected or authors are required to make major or minor revisions (both reviewer comments and editorial comments may need to be addressed). Once a revised manuscript is re-submitted, it is assessed along with the responses to reviewer comments and if it has been adequately revised it will be accepted for publication. Accepted manuscripts are then copyedited and typeset by the production team before online publication. Appeals against decisions following peer review are considered on a case by case basis and should be sent to the journal editor.
Copyright
Oncology and Therapy''s content is published open access under the Creative Commons Attribution-Noncommercial License, which allows users to read, copy, distribute, and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited. The author assigns the exclusive right to any commercial use of the article to Springer. For more information about the Creative Commons Attribution-Noncommercial License, click here: http://creativecommons.org/licenses/by-nc/4.0
Publication Fees
Upon acceptance of an article, authors will be required to pay the mandatory Rapid Service Fee of £3650/€4500/$5100. The journal will consider fee discounts for developing countries and this is decided on a case by case basis.
Open Access
All articles published by Oncology and Therapy are published open access
Contact
For more information about the journal, including pre-submission enquiries, please contact managing editor Lydia Alborn at lydia.alborn@springer.com.
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