内源性人疱疹病毒6A/B。

IF 3.8 2区医学 Q2 VIROLOGY

Journal of Virology Pub Date : 2025-09-23 Epub Date: 2025-08-01 DOI:10.1128/jvi.01054-25

Louis Flamand, Jesse Arbuckle, Pascale Bonnafous, Vincent Descamps, Joshua A Hill, Ruth Jarrett, Keith Jerome, Benedikt B Kaufer, Rie Koide, Anthony L Komaroff, Peter Medveczky, Hiroki Miura, Yasuko Mori, Nicholas Parrish, Philip E Pellett, Michael Wood, Tetsushi Yoshikawa, Danielle M Zerr

{"title":"内源性人疱疹病毒6A/B。","authors":"Louis Flamand, Jesse Arbuckle, Pascale Bonnafous, Vincent Descamps, Joshua A Hill, Ruth Jarrett, Keith Jerome, Benedikt B Kaufer, Rie Koide, Anthony L Komaroff, Peter Medveczky, Hiroki Miura, Yasuko Mori, Nicholas Parrish, Philip E Pellett, Michael Wood, Tetsushi Yoshikawa, Danielle M Zerr","doi":"10.1128/jvi.01054-25","DOIUrl":null,"url":null,"abstract":"Human herpesviruses 6A and 6B (HHV-6A/B) can integrate into the germline, resulting in inherited viral DNA-now proposed to be called \"endogenous HHV-6A/B (eHHV-6A/B).\" Present in 0.2-3% of humans, this integrated DNA is passed to offspring and may reactivate, posing health risks such as angina or lupus. To reduce confusion caused by varied terminology, researchers advocate using \"eHHV-6A/B\" for inherited forms and reserving \"chromosomally integrated\" for somatic integrations only.","PeriodicalId":17583,"journal":{"name":"Journal of Virology","volume":" ","pages":"e0105425"},"PeriodicalIF":3.8000,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12456139/pdf/","citationCount":"0","resultStr":"{\"title\":\"Endogenous human herpesviruses 6A/B.\",\"authors\":\"Louis Flamand, Jesse Arbuckle, Pascale Bonnafous, Vincent Descamps, Joshua A Hill, Ruth Jarrett, Keith Jerome, Benedikt B Kaufer, Rie Koide, Anthony L Komaroff, Peter Medveczky, Hiroki Miura, Yasuko Mori, Nicholas Parrish, Philip E Pellett, Michael Wood, Tetsushi Yoshikawa, Danielle M Zerr\",\"doi\":\"10.1128/jvi.01054-25\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Human herpesviruses 6A and 6B (HHV-6A/B) can integrate into the germline, resulting in inherited viral DNA-now proposed to be called \\\"endogenous HHV-6A/B (eHHV-6A/B).\\\" Present in 0.2-3% of humans, this integrated DNA is passed to offspring and may reactivate, posing health risks such as angina or lupus. To reduce confusion caused by varied terminology, researchers advocate using \\\"eHHV-6A/B\\\" for inherited forms and reserving \\\"chromosomally integrated\\\" for somatic integrations only.\",\"PeriodicalId\":17583,\"journal\":{\"name\":\"Journal of Virology\",\"volume\":\" \",\"pages\":\"e0105425\"},\"PeriodicalIF\":3.8000,\"publicationDate\":\"2025-09-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12456139/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Virology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1128/jvi.01054-25\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/8/1 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"VIROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Virology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1128/jvi.01054-25","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/1 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"VIROLOGY","Score":null,"Total":0}

引用次数: 0

摘要

人类疱疹病毒6A和6B （HHV-6A/B）可以整合到种系中，导致遗传病毒dna -现在被提议称为“内源性HHV-6A/B （eHHV-6A/B）”。存在于0.2% -3%的人类中，这种整合的DNA会传递给后代，并可能重新激活，带来诸如心绞痛或狼疮等健康风险。为了减少不同术语造成的混淆，研究人员主张使用“eHHV-6A/B”来表示遗传形式，而保留“染色体整合”仅用于体细胞整合。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Endogenous human herpesviruses 6A/B.

Human herpesviruses 6A and 6B (HHV-6A/B) can integrate into the germline, resulting in inherited viral DNA-now proposed to be called "endogenous HHV-6A/B (eHHV-6A/B)." Present in 0.2-3% of humans, this integrated DNA is passed to offspring and may reactivate, posing health risks such as angina or lupus. To reduce confusion caused by varied terminology, researchers advocate using "eHHV-6A/B" for inherited forms and reserving "chromosomally integrated" for somatic integrations only.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of Virology 医学-病毒学

CiteScore

10.10

自引率

7.40%

发文量

906

审稿时长

1 months

期刊介绍： Journal of Virology (JVI) explores the nature of the viruses of animals, archaea, bacteria, fungi, plants, and protozoa. We welcome papers on virion structure and assembly, viral genome replication and regulation of gene expression, genetic diversity and evolution, virus-cell interactions, cellular responses to infection, transformation and oncogenesis, gene delivery, viral pathogenesis and immunity, and vaccines and antiviral agents.