圆锥角膜眼表微生物群免疫轴的研究。

IF 2.6 4区医学 Q2 ALLERGY

Current Opinion in Allergy and Clinical Immunology Pub Date : 2025-10-01 Epub Date: 2025-08-01 DOI:10.1097/ACI.0000000000001098

Riham Shawer, Abraham Solomon

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引用次数: 0

摘要

综述目的：这篇综述的目的是给读者提供关于圆锥角膜中眼表微生物群功能的最新和发展的信息。最新发现：最近的研究支持了微生物组在圆锥角膜发病中的作用。眼表细菌产生的许多代谢物可影响宿主组织。微生物群的变化可能影响这些代谢物的组成，这可能通过改变角膜的代谢环境对圆锥角膜产生影响。摘要：了解圆锥角膜中眼表微生物群的功能可以为创造新的治疗方式开辟新的途径。

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Unraveling the immune axis of ocular surface microbiota in keratoconus.

Purpose of review: This review's objective is to give readers an update on recent and developing information about the function of the ocular surface microbiome in keratoconus.

Recent findings: The microbiome's function in the pathogenesis of keratoconus is supported by recent research. Numerous metabolites that are produced by the ocular surface bacteria can affect the host tissue. A shift in the microbiota may influence the composition of these metabolites, which could have an effect on keratoconus by altering the cornea's metabolic environment.

Summary: Gaining insight into the function of the ocular surface microbiota in keratoconus could open up new avenues for the creation of new therapeutic modalities.

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来源期刊

Current Opinion in Allergy and Clinical Immunology 医学-过敏

CiteScore

5.90

自引率

3.60%

发文量

109

审稿时长

6-12 weeks

期刊介绍： This reader-friendly, bimonthly resource provides a powerful, broad-based perspective on the most important advances from throughout the world literature. Featuring renowned guest editors and focusing exclusively on one to three topics, every issue of Current Opinion in Allergy and Clinical Immunology delivers unvarnished, expert assessments of developments from the previous year. Insightful editorials and on-the-mark invited reviews cover key subjects such as upper airway disease; mechanisms of allergy and adult asthma; paediatric asthma and development of atopy; food and drug allergies; and immunotherapy.