儿科新发中毒死亡率评分与中毒严重程度评分预测儿科重症监护病房急性中毒儿童住院死亡率的准确性

IF 2.1 4区 医学 Q3 TOXICOLOGY
Toxicology Research Pub Date : 2025-07-30 eCollection Date: 2025-08-01 DOI:10.1093/toxres/tfaf108
Meray Medhat Shokry Zaghary, Hend Gamal Aref, Wafaa Abdel-Ghaffar Ali
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引用次数: 0

摘要

小儿急性中毒是一个严重的全球公共卫生问题,是儿科发病和死亡的主要原因。探讨修改后的儿科新中毒死亡率评分(child new-PMS)用于儿科急性中毒患者的准确率,并将其与中毒严重程度评分(PSS)进行比较。本研究对2021年1月至2024年1月期间入住儿科重症监护病房(PICU)的急性儿科中毒患者(181例)进行了研究。男性占48.6%,女性占51.4%;中位年龄为5岁。从病例的命运来看,65.2%完全康复,16.57%病程复杂,18.23%死亡。50分以上患儿新经前期综合征对死亡率的判别准确率为85.3%,敏感性为78.8%,特异性为77.7%,阳性预测值为44%,阴性预测值为94%。2以上PSS对死亡率的判别准确率为84.5%,敏感性为97%,特异性为71.6%,阳性预测值为43.2%,阴性预测值为99%。结论:PSS和小儿新PMS可有效预测小儿急性中毒患者的死亡率。儿科新经前症候群评分在进入PICU之前就很容易计算,因为它取决于在院前阶段就可以获得的客观指标,如生命体征、精神状态、人口统计学和中毒相关变量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Accuracy of Pediatric new poisoning mortality score versus poisoning severity score in prediction of in-hospital mortality of acutely poisoned children admitted to Pediatric intensive care unit.

Acute pediatric poisoning is a severe global public health issue that represents a leading cause of morbidity and mortality in pediatrics. The study discussed the accuracy rate of the new PMS to be applied to pediatric acutely poisoned patients after modification to be called the pediatric new poisoning mortality score (pediatric new-PMS) and compared it to the poisoning severity score (PSS). The study was conducted on acutely pediatric intoxicated patients admitted to a pediatric intensive care unit (PICU) during the period from January 2021 to January 2024 (181 cases). 48.6% of cases were males, and 51.4% were females; the median age was 5 years. Regarding the fate of cases, 65.2% recovered completely, 16.57% recovered with a complicated course, and 18.23% died. The pediatric new-PMS above 50 points had an accuracy rate of 85.3% with good discrimination for mortality, sensitivity of 78.8%, specificity of 77.7%, positive predictive value of 44%, and negative predictive value of 94%. The PSS above 2 had an accuracy rate of 84.5% with good discrimination for mortality, sensitivity of 97%, specificity of 71.6%, positive predictive value of 43.2%, and negative predictive value of 99%. The study concluded that the PSS and pediatric new PMS can be used efficiently to predict mortality in acute pediatric intoxicated patients. The pediatric new-PMS score is easy to calculate even before admission to PICU, as it depends on objective markers that can be obtained even in the prehospital stage, such as vital signs, mental state, demographics, and poisoning-related variables.

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来源期刊
Toxicology Research
Toxicology Research TOXICOLOGY-
CiteScore
3.60
自引率
0.00%
发文量
82
期刊介绍: A multi-disciplinary journal covering the best research in both fundamental and applied aspects of toxicology
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