铱催化4-氨基吲哚的区域和对映选择性c7 -烯丙基烷基化反应。

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-07-31 DOI:10.1021/acs.orglett.5c02636

Jianbin Wang, Hang Lv and Junling Zhao*,

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引用次数: 0

摘要

报道了第一个由铱催化的4-氨基吲哚和外消旋支化烯丙基酯的分子间直接烷基化反应。不同的取代底物可在温和的反应条件下得到相应的c7 -烯丙化产物，收率中高（43-80%），区域和对映体选择性高（82-99% ee）。对产品中的乙烯基进行了代表性的转化，以检验该方案的实用性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Iridium-Catalyzed Regio- and Enantioselective C7-Allylic Alkylation of 4-Aminoindoles

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Iridium-Catalyzed Regio- and Enantioselective C7-Allylic Alkylation of 4-Aminoindoles

The first iridium-catalyzed direct intermolecular indole C7-allylic alkylation of 4-aminoindoles and racemic branched allylic esters was reported. Various substituted substrates were applicable to give the corresponding C7-allylated products in moderate to high yields (43–80%) with high regio- and enantioselectivities (82–99% ee) under mild reaction conditions. Representative transformations of the vinyl group in the product were carried out to examine the utility of this protocol.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.