波兰儿童1型糖尿病发病时糖尿病酮症酸中毒患病率的变化:2006-2014年和2015-2023年两个9年期间的比较分析

IF 5.6 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Pediatric Diabetes Pub Date : 2025-07-23 eCollection Date: 2025-01-01 DOI:10.1155/pedi/8927409
Elżbieta Niechciał, Michał Bielecki, Adrianna Geppert, Sebastian Kokociński, Kamil Kopa, Patrycja Wiącek, Oliwia Witkowska, Laura Dwulit, Olga Mejer, Andrzej Kędzia
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引用次数: 0

摘要

目的:随着1型糖尿病(T1D)患病率的逐渐增加,发病时发生糖尿病酮症酸中毒(DKA)的风险可能越来越大。DKA的患病率因地理区域而异,从瑞典的约13%到阿拉伯联合酋长国的80%不等。本研究旨在比较大波兰(波兰)在两个9年期间儿童发病T1D中DKA的患病率。方法:我们评估了年龄儿童DKA的患病率。结果:18岁以下新诊断T1D的儿童2432例。DKA总体患病率为51.3% (n = 1248),在两个9年期间呈显著上升趋势,从2006-2014年的47.7%上升至2015-2023年的53.4% (p=0.007)。有显著的转变向更严重的DKA表现。轻度DKA患病率从51.3%下降到47.0% (p=0.145),中度DKA患病率从33.1%下降到25.2% (p=0.003),重度DKA患病率从15.5%急剧上升到27.7% (p < 0.001)。结论:尽管T1D在波兰的发病率越来越高,但医疗保健和父母对T1D症状的认识仍然很低,这导致T1D的识别延迟。儿童T1D发病时DKA的发病率不断上升是一个令人担忧的公共卫生问题,需要采取多方面的教育、预防和早期干预措施。解决这些挑战可能有助于减少DKA的患病率,并改善T1D儿童的临床结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Changes in the Prevalence of Diabetes Ketoacidosis at the Onset of Type 1 Diabetes in Polish Children: A Comparative Analysis Between Two 9-Year Periods-2006-2014 and 2015-2023.

Changes in the Prevalence of Diabetes Ketoacidosis at the Onset of Type 1 Diabetes in Polish Children: A Comparative Analysis Between Two 9-Year Periods-2006-2014 and 2015-2023.

Objective: Having been facing a progressive increase in the prevalence of type 1 diabetes (T1D), there might be a growing risk of the development of diabetic ketoacidosis (DKA) at disease onset. The prevalence of DKA varies widely by geographic region, ranging from approximately 13% in Sweden to 80% in the United Arab Emirates. This study aimed to compare the prevalence of DKA in childhood-onset T1D from Greater Poland (Poland) in two 9-year periods. Methods: We assessed the prevalence of DKA in children aged <18 years with newly diagnosed T1D in Greater Poland (Poland) in two 9-year periods, 2006-2014 and 2015-2023, in a retrospective review of a complete regional cohort. DKA and its severity were classified according to International Society for Pediatric and Adolescent Diabetes (ISPAD) guidelines. Results: Over the 18 years, 2432 children below 18 years of age with newly diagnosed T1D were recorded. The overall prevalence of DKA was 51.3% (n = 1248), and it rose significantly in two nine-year periods, from 47.7% in 2006-2014 to 53.4% in 2015-2023 (p=0.007). There was a significant shift toward more severe presentations of DKA. While the prevalence of mild DKA decreased slightly from 51.3% to 47.0% (p=0.145), and moderate DKA had a notable decline from 33.1% to 25.2% (p=0.003), the proportion of severe DKA cases rose sharply from 15.5% to 27.7% (p < 0.001). Conclusions: Despite the increasing incidence of T1D in Poland, healthcare, and parental awareness of T1D symptoms remain low, which results in delayed T1D recognition. The escalating prevalence of DKA at T1D onset in children is a concerning public health issue that necessitates a multifaceted approach to education, prevention, and early intervention. Addressing these challenges might help reduce the prevalence of DKA and improve clinical outcomes for children with T1D.

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来源期刊
Pediatric Diabetes
Pediatric Diabetes 医学-内分泌学与代谢
CiteScore
6.60
自引率
14.70%
发文量
141
审稿时长
4-8 weeks
期刊介绍: Pediatric Diabetes is a bi-monthly journal devoted to disseminating new knowledge relating to the epidemiology, etiology, pathogenesis, management, complications and prevention of diabetes in childhood and adolescence. The aim of the journal is to become the leading vehicle for international dissemination of research and practice relating to diabetes in youth. Papers are considered for publication based on the rigor of scientific approach, novelty, and importance for understanding mechanisms involved in the epidemiology and etiology of this disease, especially its molecular, biochemical and physiological aspects. Work relating to the clinical presentation, course, management and outcome of diabetes, including its physical and emotional sequelae, is considered. In vitro studies using animal or human tissues, whole animal and clinical studies in humans are also considered. The journal reviews full-length papers, preliminary communications with important new information, clinical reports, and reviews of major topics. Invited editorials, commentaries, and perspectives are a regular feature. The editors, based in the USA, Europe, and Australasia, maintain regular communications to assure rapid turnaround time of submitted manuscripts.
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