Meixuan Li , Tao Ma , Jianming Li , Zhuangyuan Meng , Yunhan Cai , Chen Peng , Shengzhang Wang
{"title":"降低主动脉支架的回弹力-降低支架诱导的新入腔风险","authors":"Meixuan Li , Tao Ma , Jianming Li , Zhuangyuan Meng , Yunhan Cai , Chen Peng , Shengzhang Wang","doi":"10.1016/j.cmpb.2025.108993","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>This study utilized patient-specific model to quantitatively analyze, from a mechanical perspective, the impact of reducing the spring-back force of the stent graft on the proximal and distal landing zones of the aorta after thoracic endovascular aortic repair (TEVAR).</div></div><div><h3>Methods</h3><div>A patient-specific aortic dissection (AD) model was established based on preoperative computed tomography angiogram (CTA) images. The stent graft structure, according to the stent graft actually used by the patient, was optimized to reduce spring-back force using the Isight (Dassault Systèmes, France) optimization design platform, in combination with the Kriging model and Non-dominated sorting genetic algorithm (NSGA-II). The final optimized stent graft was virtually implanted into the patient’s aorta and compared with the original stent graft to analyze, from a mechanical perspective, the impact of reducing the spring-back force of the stent graft on the proximal and distal landing zones after TEVAR.</div></div><div><h3>Results</h3><div>In the proximal landing zone, the peak value of maximum principal stress caused by the final optimized stent graft was 257.0 KPa, a 1.5 % reduction compared to the original stent graft. In the distal landing zone, the peak value of maximum principal stress was 148.7 KPa, a 19.9 % reduction compared to the original stent graft. The reduction in peak maximum principal stress in the distal landing zone was much greater than in the proximal landing zone. Before and after optimization, the location of the peak value of maximum principal stress in the distal landing zone remained at the boundary of the intima flap and was located on the greater curvature of the aorta.</div></div><div><h3>Conclusion</h3><div>Reducing the spring-back force of the stent graft can decrease the stress on the proximal and distal landing zones of the aorta, thereby reducing the risk of stent graft-induced new entry.</div></div>","PeriodicalId":10624,"journal":{"name":"Computer methods and programs in biomedicine","volume":"271 ","pages":"Article 108993"},"PeriodicalIF":4.8000,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Reducing the spring-back force of the aortic stent graft — decreasing the risk of stent graft-induced new entry\",\"authors\":\"Meixuan Li , Tao Ma , Jianming Li , Zhuangyuan Meng , Yunhan Cai , Chen Peng , Shengzhang Wang\",\"doi\":\"10.1016/j.cmpb.2025.108993\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><div>This study utilized patient-specific model to quantitatively analyze, from a mechanical perspective, the impact of reducing the spring-back force of the stent graft on the proximal and distal landing zones of the aorta after thoracic endovascular aortic repair (TEVAR).</div></div><div><h3>Methods</h3><div>A patient-specific aortic dissection (AD) model was established based on preoperative computed tomography angiogram (CTA) images. The stent graft structure, according to the stent graft actually used by the patient, was optimized to reduce spring-back force using the Isight (Dassault Systèmes, France) optimization design platform, in combination with the Kriging model and Non-dominated sorting genetic algorithm (NSGA-II). The final optimized stent graft was virtually implanted into the patient’s aorta and compared with the original stent graft to analyze, from a mechanical perspective, the impact of reducing the spring-back force of the stent graft on the proximal and distal landing zones after TEVAR.</div></div><div><h3>Results</h3><div>In the proximal landing zone, the peak value of maximum principal stress caused by the final optimized stent graft was 257.0 KPa, a 1.5 % reduction compared to the original stent graft. In the distal landing zone, the peak value of maximum principal stress was 148.7 KPa, a 19.9 % reduction compared to the original stent graft. The reduction in peak maximum principal stress in the distal landing zone was much greater than in the proximal landing zone. Before and after optimization, the location of the peak value of maximum principal stress in the distal landing zone remained at the boundary of the intima flap and was located on the greater curvature of the aorta.</div></div><div><h3>Conclusion</h3><div>Reducing the spring-back force of the stent graft can decrease the stress on the proximal and distal landing zones of the aorta, thereby reducing the risk of stent graft-induced new entry.</div></div>\",\"PeriodicalId\":10624,\"journal\":{\"name\":\"Computer methods and programs in biomedicine\",\"volume\":\"271 \",\"pages\":\"Article 108993\"},\"PeriodicalIF\":4.8000,\"publicationDate\":\"2025-07-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Computer methods and programs in biomedicine\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0169260725004109\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Computer methods and programs in biomedicine","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0169260725004109","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS","Score":null,"Total":0}
Reducing the spring-back force of the aortic stent graft — decreasing the risk of stent graft-induced new entry
Objective
This study utilized patient-specific model to quantitatively analyze, from a mechanical perspective, the impact of reducing the spring-back force of the stent graft on the proximal and distal landing zones of the aorta after thoracic endovascular aortic repair (TEVAR).
Methods
A patient-specific aortic dissection (AD) model was established based on preoperative computed tomography angiogram (CTA) images. The stent graft structure, according to the stent graft actually used by the patient, was optimized to reduce spring-back force using the Isight (Dassault Systèmes, France) optimization design platform, in combination with the Kriging model and Non-dominated sorting genetic algorithm (NSGA-II). The final optimized stent graft was virtually implanted into the patient’s aorta and compared with the original stent graft to analyze, from a mechanical perspective, the impact of reducing the spring-back force of the stent graft on the proximal and distal landing zones after TEVAR.
Results
In the proximal landing zone, the peak value of maximum principal stress caused by the final optimized stent graft was 257.0 KPa, a 1.5 % reduction compared to the original stent graft. In the distal landing zone, the peak value of maximum principal stress was 148.7 KPa, a 19.9 % reduction compared to the original stent graft. The reduction in peak maximum principal stress in the distal landing zone was much greater than in the proximal landing zone. Before and after optimization, the location of the peak value of maximum principal stress in the distal landing zone remained at the boundary of the intima flap and was located on the greater curvature of the aorta.
Conclusion
Reducing the spring-back force of the stent graft can decrease the stress on the proximal and distal landing zones of the aorta, thereby reducing the risk of stent graft-induced new entry.
期刊介绍:
To encourage the development of formal computing methods, and their application in biomedical research and medical practice, by illustration of fundamental principles in biomedical informatics research; to stimulate basic research into application software design; to report the state of research of biomedical information processing projects; to report new computer methodologies applied in biomedical areas; the eventual distribution of demonstrable software to avoid duplication of effort; to provide a forum for discussion and improvement of existing software; to optimize contact between national organizations and regional user groups by promoting an international exchange of information on formal methods, standards and software in biomedicine.
Computer Methods and Programs in Biomedicine covers computing methodology and software systems derived from computing science for implementation in all aspects of biomedical research and medical practice. It is designed to serve: biochemists; biologists; geneticists; immunologists; neuroscientists; pharmacologists; toxicologists; clinicians; epidemiologists; psychiatrists; psychologists; cardiologists; chemists; (radio)physicists; computer scientists; programmers and systems analysts; biomedical, clinical, electrical and other engineers; teachers of medical informatics and users of educational software.