降低主动脉支架的回弹力-降低支架诱导的新入腔风险

IF 4.8 2区 医学 Q1 COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS
Meixuan Li , Tao Ma , Jianming Li , Zhuangyuan Meng , Yunhan Cai , Chen Peng , Shengzhang Wang
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引用次数: 0

摘要

目的本研究利用患者特异性模型,从力学角度定量分析降低支架回弹力对胸血管内主动脉修复(TEVAR)术后主动脉近端和远端着陆区的影响。方法基于术前ct血管造影(CTA)图像建立患者特异性主动脉夹层(AD)模型。根据患者实际使用的支架,利用Isight (Dassault systemmes, France)优化设计平台,结合Kriging模型和非支配排序遗传算法(NSGA-II)对支架结构进行优化,减小回弹力。将最终优化的支架虚拟植入患者主动脉,与原支架进行比较,从力学角度分析降低支架回弹力对TEVAR后近端和远端着陆区的影响。结果在近端着陆区,优化后的支架最大主应力峰值为257.0 KPa,比原支架降低1.5%。在远端着陆区,最大主应力峰值为148.7 KPa,比原支架降低19.9%。远端着陆区最大主应力峰值减小幅度远大于近端着陆区。优化前后,远端着落区最大主应力峰值位置保持在内膜瓣边界,位于主动脉大曲率处。结论降低支架回弹力可以降低主动脉近端和远端着陆区的应力,从而降低支架诱导新入的风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Reducing the spring-back force of the aortic stent graft — decreasing the risk of stent graft-induced new entry

Objective

This study utilized patient-specific model to quantitatively analyze, from a mechanical perspective, the impact of reducing the spring-back force of the stent graft on the proximal and distal landing zones of the aorta after thoracic endovascular aortic repair (TEVAR).

Methods

A patient-specific aortic dissection (AD) model was established based on preoperative computed tomography angiogram (CTA) images. The stent graft structure, according to the stent graft actually used by the patient, was optimized to reduce spring-back force using the Isight (Dassault Systèmes, France) optimization design platform, in combination with the Kriging model and Non-dominated sorting genetic algorithm (NSGA-II). The final optimized stent graft was virtually implanted into the patient’s aorta and compared with the original stent graft to analyze, from a mechanical perspective, the impact of reducing the spring-back force of the stent graft on the proximal and distal landing zones after TEVAR.

Results

In the proximal landing zone, the peak value of maximum principal stress caused by the final optimized stent graft was 257.0 KPa, a 1.5 % reduction compared to the original stent graft. In the distal landing zone, the peak value of maximum principal stress was 148.7 KPa, a 19.9 % reduction compared to the original stent graft. The reduction in peak maximum principal stress in the distal landing zone was much greater than in the proximal landing zone. Before and after optimization, the location of the peak value of maximum principal stress in the distal landing zone remained at the boundary of the intima flap and was located on the greater curvature of the aorta.

Conclusion

Reducing the spring-back force of the stent graft can decrease the stress on the proximal and distal landing zones of the aorta, thereby reducing the risk of stent graft-induced new entry.
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来源期刊
Computer methods and programs in biomedicine
Computer methods and programs in biomedicine 工程技术-工程:生物医学
CiteScore
12.30
自引率
6.60%
发文量
601
审稿时长
135 days
期刊介绍: To encourage the development of formal computing methods, and their application in biomedical research and medical practice, by illustration of fundamental principles in biomedical informatics research; to stimulate basic research into application software design; to report the state of research of biomedical information processing projects; to report new computer methodologies applied in biomedical areas; the eventual distribution of demonstrable software to avoid duplication of effort; to provide a forum for discussion and improvement of existing software; to optimize contact between national organizations and regional user groups by promoting an international exchange of information on formal methods, standards and software in biomedicine. Computer Methods and Programs in Biomedicine covers computing methodology and software systems derived from computing science for implementation in all aspects of biomedical research and medical practice. It is designed to serve: biochemists; biologists; geneticists; immunologists; neuroscientists; pharmacologists; toxicologists; clinicians; epidemiologists; psychiatrists; psychologists; cardiologists; chemists; (radio)physicists; computer scientists; programmers and systems analysts; biomedical, clinical, electrical and other engineers; teachers of medical informatics and users of educational software.
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