依加替莫德联合类固醇治疗HAM/TSP 1例报告。

IF 3.9 2区医学 Q1 CLINICAL NEUROLOGY

Annals of Clinical and Translational Neurology Pub Date : 2025-07-30 DOI:10.1002/acn3.70156

Jiahui Zeng, Wotu Tian, Jingran Yang, Yanping Yang, Li Cao, Xinghua Luan

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引用次数: 0

摘要

htlv -1相关脊髓病/热带痉挛性截瘫（HAM/TSP）是一种进行性神经系统疾病，治疗方案有限。我们报告了一位54岁女性，患有10年进行性HAM/TSP，先前对利妥昔单抗难治性，经历了痉挛性截瘫和神经源性膀胱功能障碍的恶化。经依加替莫德和皮质类固醇联合治疗后，患者痉挛、膀胱功能和生活质量均有显著改善。该病例突出了艾加替莫德作为难治性HAM/TSP辅助治疗的潜力，提示了一种新的免疫调节策略，并值得进一步研究联合治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Efgartigimod Combined With Steroid Treatment for HAM/TSP: A Case Report

查看原文本刊更多论文

Efgartigimod Combined With Steroid Treatment for HAM/TSP: A Case Report

HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a progressive neurological disorder with limited treatment options. We report a 54-year-old female with decade-long, progressive HAM/TSP, previously refractory to rituximab, who experienced worsening spastic paraparesis and neurogenic bladder dysfunction. She showed remarkable improvement in spasticity, bladder function, and quality of life following combination therapy with efgartigimod and corticosteroids. This case highlights efgartigimod's potential as an adjunctive therapy for refractory HAM/TSP, suggesting a new immune modulation strategy and warranting further research into combination treatments.

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来源期刊

Annals of Clinical and Translational Neurology Medicine-Neurology (clinical)

CiteScore

9.10

自引率

1.90%

发文量

218

审稿时长

8 weeks

期刊介绍： Annals of Clinical and Translational Neurology is a peer-reviewed journal for rapid dissemination of high-quality research related to all areas of neurology. The journal publishes original research and scholarly reviews focused on the mechanisms and treatments of diseases of the nervous system; high-impact topics in neurologic education; and other topics of interest to the clinical neuroscience community.