{"title":"egfr突变的肺腺癌向鳞状细胞癌转化过程中获得FGFR1和NSD3扩增：1例报告","authors":"Naoki Fukunaga MD , Hideki Terai MD, PhD , Rui Nomura MD , Yutaka Kurebayashi MD, PhD , Kohei Nakamura MD, PhD , Ryutaro Kawano MD , Kohei Shigeta MD, PhD , Koji Okabayashi MD , Katsuhito Kinoshita MD , Akihiko Ogata MD , Lisa Shigematsu MD , Fumimaro Ito MD , Hatsuyo Takaoka MD , Takahiro Fukushima MD , Shigenari Nukaga MD, PhD , Keiko Ohgino MD, PhD , Hiroyuki Yasuda MD, PhD , Hiroshi Nishihara MD, PhD , Yuko Kitagawa MD, PhD , Koichi Fukunaga MD, PhD","doi":"10.1016/j.jtocrr.2025.100862","DOIUrl":null,"url":null,"abstract":"<div><div>Histologic transformation from adenocarcinoma to SCLC is a recognized mechanism of resistance in lung cancer. However, the transformation into squamous cell carcinoma is less common, and the associated genomic alterations remain unclear. Here, we present a case of lung adenocarcinoma harboring an EGFR (<em>EGFR</em>) mutation that transformed into squamous cell carcinoma. Although <em>EGFR</em> L858R mutation was detected throughout the transformation, genomic analyses were performed during the disease course, revealing the amplification of <em>FGFR1</em> and <em>NSD3</em>, which have recently been proposed as potential driver oncogenes in lung squamous cell carcinoma. This case report highlights the genomic alterations observed in repeatedly biopsied specimens, along with a review of the relevant literature.</div></div>","PeriodicalId":17675,"journal":{"name":"JTO Clinical and Research Reports","volume":"6 9","pages":"Article 100862"},"PeriodicalIF":3.5000,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Acquisition of FGFR1 and NSD3 Amplifications During the Transformation of EGFR-Mutated Lung Adenocarcinoma into Squamous Cell Carcinoma: A Case Report\",\"authors\":\"Naoki Fukunaga MD , Hideki Terai MD, PhD , Rui Nomura MD , Yutaka Kurebayashi MD, PhD , Kohei Nakamura MD, PhD , Ryutaro Kawano MD , Kohei Shigeta MD, PhD , Koji Okabayashi MD , Katsuhito Kinoshita MD , Akihiko Ogata MD , Lisa Shigematsu MD , Fumimaro Ito MD , Hatsuyo Takaoka MD , Takahiro Fukushima MD , Shigenari Nukaga MD, PhD , Keiko Ohgino MD, PhD , Hiroyuki Yasuda MD, PhD , Hiroshi Nishihara MD, PhD , Yuko Kitagawa MD, PhD , Koichi Fukunaga MD, PhD\",\"doi\":\"10.1016/j.jtocrr.2025.100862\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Histologic transformation from adenocarcinoma to SCLC is a recognized mechanism of resistance in lung cancer. However, the transformation into squamous cell carcinoma is less common, and the associated genomic alterations remain unclear. Here, we present a case of lung adenocarcinoma harboring an EGFR (<em>EGFR</em>) mutation that transformed into squamous cell carcinoma. Although <em>EGFR</em> L858R mutation was detected throughout the transformation, genomic analyses were performed during the disease course, revealing the amplification of <em>FGFR1</em> and <em>NSD3</em>, which have recently been proposed as potential driver oncogenes in lung squamous cell carcinoma. This case report highlights the genomic alterations observed in repeatedly biopsied specimens, along with a review of the relevant literature.</div></div>\",\"PeriodicalId\":17675,\"journal\":{\"name\":\"JTO Clinical and Research Reports\",\"volume\":\"6 9\",\"pages\":\"Article 100862\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2025-06-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"JTO Clinical and Research Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2666364325000797\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"JTO Clinical and Research Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666364325000797","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}
Acquisition of FGFR1 and NSD3 Amplifications During the Transformation of EGFR-Mutated Lung Adenocarcinoma into Squamous Cell Carcinoma: A Case Report
Histologic transformation from adenocarcinoma to SCLC is a recognized mechanism of resistance in lung cancer. However, the transformation into squamous cell carcinoma is less common, and the associated genomic alterations remain unclear. Here, we present a case of lung adenocarcinoma harboring an EGFR (EGFR) mutation that transformed into squamous cell carcinoma. Although EGFR L858R mutation was detected throughout the transformation, genomic analyses were performed during the disease course, revealing the amplification of FGFR1 and NSD3, which have recently been proposed as potential driver oncogenes in lung squamous cell carcinoma. This case report highlights the genomic alterations observed in repeatedly biopsied specimens, along with a review of the relevant literature.
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