Silver-catalyzed/NBS-mediated regioselective bromophosphoryloxylation of alkynes with P(O)-OH bonds

A facile and convenient silver-catalyzed/NBS-mediated regioselective bromophosphoryloxylation of alkynes with P(O)-OH bonds has been developed. This methodology provides a straightforward approach for the difunctionalization of alkynes, enabling the synthesis of α-phosphoryl-substituted β‑bromo styrene derivatives. Notably, the reaction exhibits broad substrate scope, accommodating diverse alkyne and P(O)-OH compounds with varied electronic and steric properties, and affords corresponding products in moderate to excellent yields. Mechanistic studies, including controlled stepwise experiments, further support a plausible reaction pathway.