{"title":"肺移植术后肺功能检测报告的国际惯例","authors":"Jens Gottlieb MD , Erika Lease MD , Merel Hellemons MD, PhD , Kieran Halloran MD , Tereza Martinu MD, MHSc","doi":"10.1016/j.jhlto.2025.100347","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Spirometry interpretation after lung transplantation (LTx) is complex, requiring a clear understanding of reference values and normal thresholds globally. Abnormal values are typically based on general population reference standards.</div></div><div><h3>Methods</h3><div>In April 2025, a 10-question online survey was conducted among International Society of Heart and Lung Transplantation-members to determine the reference values and normal thresholds used worldwide for post-transplant spirometry interpretation.</div></div><div><h3>Results</h3><div>Responses from 58 centers, covering 22,080 lung transplant recipients and representing ∼40% of global transplant activity, were analyzed. Most patients (63%) were followed in the United States or Canada. Global lung initiative (GLI) reference was used for 60%, with 47% using the race-neutral version. The lower limit of normal (LLN) was reported in only 19% of pulmonary function assessments. Regional differences were noted in obstruction definition and impairment grading.</div></div><div><h3>Conclusions</h3><div>While GLI-reference values are widely adopted, 40% of centers have yet to implement them, and LLN remains underutilized in spirometry reporting after LTx.</div></div>","PeriodicalId":100741,"journal":{"name":"JHLT Open","volume":"9 ","pages":"Article 100347"},"PeriodicalIF":0.0000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Worldwide practices in pulmonary function test reporting after lung transplantation\",\"authors\":\"Jens Gottlieb MD , Erika Lease MD , Merel Hellemons MD, PhD , Kieran Halloran MD , Tereza Martinu MD, MHSc\",\"doi\":\"10.1016/j.jhlto.2025.100347\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Spirometry interpretation after lung transplantation (LTx) is complex, requiring a clear understanding of reference values and normal thresholds globally. Abnormal values are typically based on general population reference standards.</div></div><div><h3>Methods</h3><div>In April 2025, a 10-question online survey was conducted among International Society of Heart and Lung Transplantation-members to determine the reference values and normal thresholds used worldwide for post-transplant spirometry interpretation.</div></div><div><h3>Results</h3><div>Responses from 58 centers, covering 22,080 lung transplant recipients and representing ∼40% of global transplant activity, were analyzed. Most patients (63%) were followed in the United States or Canada. Global lung initiative (GLI) reference was used for 60%, with 47% using the race-neutral version. The lower limit of normal (LLN) was reported in only 19% of pulmonary function assessments. Regional differences were noted in obstruction definition and impairment grading.</div></div><div><h3>Conclusions</h3><div>While GLI-reference values are widely adopted, 40% of centers have yet to implement them, and LLN remains underutilized in spirometry reporting after LTx.</div></div>\",\"PeriodicalId\":100741,\"journal\":{\"name\":\"JHLT Open\",\"volume\":\"9 \",\"pages\":\"Article 100347\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"JHLT Open\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2950133425001429\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"JHLT Open","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2950133425001429","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
肺移植（LTx）后肺活量测定的解释是复杂的，需要清楚地了解参考值和全球正常阈值。异常值通常基于一般人群参考标准。方法2025年4月，在国际心肺移植学会（International Society of Heart and Lung transplantation）成员中进行了一项包含10个问题的在线调查，以确定全球范围内用于移植后肺活量测定解释的参考值和正常阈值。结果分析了来自58个中心的回复，涵盖22,080名肺移植受者，占全球移植活动的40%。大多数患者（63%）在美国或加拿大接受了随访。60%的人使用全球肺倡议（GLI）参考，47%的人使用种族中立版本。只有19%的肺功能评估报告了正常（LLN）的下限。在梗阻定义和损伤分级方面存在区域差异。结论虽然glii参考值被广泛采用，但40%的中心尚未实施，LLN在LTx后肺活量报告中仍未得到充分利用。
Worldwide practices in pulmonary function test reporting after lung transplantation
Background
Spirometry interpretation after lung transplantation (LTx) is complex, requiring a clear understanding of reference values and normal thresholds globally. Abnormal values are typically based on general population reference standards.
Methods
In April 2025, a 10-question online survey was conducted among International Society of Heart and Lung Transplantation-members to determine the reference values and normal thresholds used worldwide for post-transplant spirometry interpretation.
Results
Responses from 58 centers, covering 22,080 lung transplant recipients and representing ∼40% of global transplant activity, were analyzed. Most patients (63%) were followed in the United States or Canada. Global lung initiative (GLI) reference was used for 60%, with 47% using the race-neutral version. The lower limit of normal (LLN) was reported in only 19% of pulmonary function assessments. Regional differences were noted in obstruction definition and impairment grading.
Conclusions
While GLI-reference values are widely adopted, 40% of centers have yet to implement them, and LLN remains underutilized in spirometry reporting after LTx.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
