不饱和醇侧链通过无迹激活基团的区域发散中断镍催化链行走。

IF 15.6 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Journal of the American Chemical Society Pub Date : 2025-07-30 DOI:10.1021/jacs.5c09426

Hao Wang, Huihui Zhang, Marta Martínez-Belmonte, Jordi Benet-Buchholz and Ruben Martin*,

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引用次数: 0

摘要

在这里，我们描述了不饱和脂肪醇的区域发散中断链行走。该方法利用无迹基团的潜力，在远端亚甲基sp3 C- h位点上形成C(sp3)-C（sp3）和C(sp3)-氮键，通过明智地选择配体来选择位点。该方案的特点是其广泛的适用性，提供非常规的分离，以获得β/γ-取代的脂肪族醇，否则很难达到。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Regiodivergent Interrupted Ni-Catalyzed Chain-Walking of Unsaturated Alcohol Side-Chains via Traceless Activating Groups

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Regiodivergent Interrupted Ni-Catalyzed Chain-Walking of Unsaturated Alcohol Side-Chains via Traceless Activating Groups

Herein, we describe a regiodivergent interrupted chain-walking of unsaturated aliphatic alcohols. The method leverages the potential of traceless groups to forge C(sp³)–C(sp³) and C(sp³)–nitrogen bonds at distal methylene sp³ C–H sites, with site selectivity dictated by a judicious choice of the ligand. The protocol is distinguished by its broad applicability, offering unconventional disconnections to access β/γ-substituted aliphatic alcohols that are difficult to reach otherwise.

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来源期刊

Journal of the American Chemical Society 化学-化学综合

CiteScore

24.40

自引率

6.00%

发文量

2398

审稿时长

1.6 months

期刊介绍： The flagship journal of the American Chemical Society, known as the Journal of the American Chemical Society (JACS), has been a prestigious publication since its establishment in 1879. It holds a preeminent position in the field of chemistry and related interdisciplinary sciences. JACS is committed to disseminating cutting-edge research papers, covering a wide range of topics, and encompasses approximately 19,000 pages of Articles, Communications, and Perspectives annually. With a weekly publication frequency, JACS plays a vital role in advancing the field of chemistry by providing essential research.