Hao Wang,Huihui Zhang,Marta Martínez-Belmonte,Jordi Benet-Buchholz,Ruben Martin
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Regiodivergent Interrupted Ni-Catalyzed Chain-Walking of Unsaturated Alcohol Side-Chains via Traceless Activating Groups.
Herein, we describe a regiodivergent interrupted chain-walking of unsaturated aliphatic alcohols. The method leverages the potential of traceless groups to forge C(sp3)-C(sp3) and C(sp3)-nitrogen bonds at distal methylene sp3 C-H sites, with site selectivity dictated by a judicious choice of the ligand. The protocol is distinguished by its broad applicability, offering unconventional disconnections to access β/γ-substituted aliphatic alcohols that are difficult to reach otherwise.
期刊介绍:
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