健康成人输水管脑脊液流量参数的相位对比MRI测量的内部和内部可靠性

IF 2.3 2区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Quantitative Imaging in Medicine and Surgery Pub Date : 2025-07-01 Epub Date: 2025-06-30 DOI:10.21037/qims-24-1589
Pan Liu, Yann Attekeble, Jiachen Xie, Kimi Owashi, Heimiri Monnier, Serge Metanbou, Cyrille Capel, Olivier Balédent
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引用次数: 0

摘要

背景:脑脊液(CSF)水动力学参数对神经退行性疾病的认识和诊断至关重要。本研究旨在评估采用相衬磁共振成像(PC-MRI)在健康成人不同操作人员中测量的输水管脑脊液流量参数的管间和管内可靠性。方法:选取38名健康成人为研究对象。三名操作员使用PC-MRI独立量化输水管CSF流量参数。测量的参数包括水面(渡槽的横截面积)、每冲程净流量、流量振幅、峰值平均流速和冲程体积。使用类内相关系数[inter - ater的ICC(3,1)和inter - ater信度的ICC(1,1)]来评估测量一致性。非参数测试评估了速度编码(VENC)、性别、年龄和心脏周期对测量变异性的影响。结果:大部分渡槽参数具有良好至优异的可靠性,其ICC(3,1)值在0.75 ~ 0.99之间。Surface的可靠性较差,ICC(3,1)为0.37,ICC(1,1)为0.33、0.54和0.84。净流量表现出中等的一致性,ICC(3,1)为0.84,ICC(1,1)为0.78,0.87和0.92。VENC显著增加了噪声强度,降低了净流量可靠性(结论:研究证实,PC-MRI测量的大多数渡槽CSF流量参数在不同操作人员和重复测量中都是可靠的。然而,由于可靠性较低,净流量和表面积需要仔细考虑。这些结果为脑脊液水动力学测量在神经退行性疾病诊断和监测中的临床应用提供了有价值的参考。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Interrater and intrarater reliability of aqueduct CSF flow parameters measured by phase-contrast MRI in healthy adults.

Background: Cerebrospinal fluid (CSF) hydrodynamic parameters at the aqueduct of Sylvius are critical for understanding and diagnosing neurodegenerative diseases. This study aims to assess both interrater and intrarater reliability of aqueduct CSF flow parameters measured by phase-contrast magnetic resonance imaging (PC-MRI) across different operators in healthy adults.

Methods: Thirty-eight healthy adult participants were included in the study. Three operators independently quantified aqueduct CSF flow parameters using PC-MRI. Parameters measured included surface (cross-sectional area of aqueduct), net flow per stroke, flow amplitude, peak mean velocity, and stroke volume. Intraclass correlation coefficients [ICC (3,1) for interrater and ICC (1,1) for intrarater reliability] were used to evaluate measurement consistency. Non-parametric tests assessed the impact of velocity encoding (VENC), sex, age, and cardiac period on measurement variability.

Results: Most aqueduct parameters exhibited good to excellent reliability, with ICC (3,1) values ranging from 0.75 to 0.99. Surface demonstrated poor reliability with an ICC (3,1) of 0.37 and ICC (1,1) of 0.33, 0.54 and 0.84. Net flow rate demonstrated moderate consistency with an ICC (3,1) of 0.84 and ICC (1,1) of 0.78, 0.87 and 0.92. VENC significantly increased noise intensity and decreased net flow rate reliability (P<0.01). Gender analysis showed that males had significantly higher surface area (P<0.01), stroke volume (P=0.04), and net flow rate (P<0.01) compared to females.

Conclusions: The study confirmed that most aqueduct CSF flow parameters measured by PC-MRI are reliable both across different operators and in repeated measurements. However, net flow rate and surface area require careful consideration due to lower reliability. These findings provide a valuable reference for the clinical application of CSF hydrodynamic measurements in diagnosing and monitoring neurodegenerative diseases.

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来源期刊
Quantitative Imaging in Medicine and Surgery
Quantitative Imaging in Medicine and Surgery Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
4.20
自引率
17.90%
发文量
252
期刊介绍: Information not localized
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