{"title":"胆囊切除术与显微结肠炎的风险：一项系统综述和荟萃分析。","authors":"Zhaoxu Tian, Hongying Tang, Guoming Sun, Jianjun Shen, Yangri Duan, Hangbin Jin","doi":"10.1177/17562848251357067","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Several observational studies suggest a potential association between cholecystectomy and the risk of developing microscopic colitis (MC). However, the current findings remain inconsistent.</p><p><strong>Objectives: </strong>To address this discrepancy, we conducted a systematic review and meta-analysis to comprehensively assess the association between cholecystectomy and the risk of MC.</p><p><strong>Design: </strong>Systematic review and meta-analysis.</p><p><strong>Data sources and methods: </strong>A systematic search of PubMed, Embase, and Web of Science was conducted to identify studies evaluating the association between cholecystectomy and MC risk. Studies were eligible if they reported effect estimates or provided sufficient data for calculation. Two independent authors extracted the data and assessed the quality of included studies. A random-effects model was used to pool odds ratios (ORs), with subgroup analyses performed according to patient characteristics and study quality.</p><p><strong>Results: </strong>Six observational studies were included in the final analysis. The pooled OR was 0.80 (95% confidence interval: 0.52-1.22), and sensitivity analysis confirmed the robustness of the results, indicating no significant association between cholecystectomy and MC risk. Subgroup analyses based on geographic location, study design, study quality, methods of cholecystectomy data collection, control populations, and MC subtypes consistently showed no significant association.</p><p><strong>Conclusion: </strong>Current evidence suggests no statistically significant association between cholecystectomy and the risk of MC. Future research should include populations with diverse geographic and ethnic backgrounds, utilize medical records for accurate surgical history, and account for potential confounding factors. Large-scale prospective studies will be essential to obtain more reliable and definitive conclusions.</p><p><strong>Trial prospero registration: </strong>CRD42024592056.</p>","PeriodicalId":48770,"journal":{"name":"Therapeutic Advances in Gastroenterology","volume":"18 ","pages":"17562848251357067"},"PeriodicalIF":3.4000,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12290341/pdf/","citationCount":"0","resultStr":"{\"title\":\"Cholecystectomy and the risk of microscopic colitis: a systematic review and meta-analysis.\",\"authors\":\"Zhaoxu Tian, Hongying Tang, Guoming Sun, Jianjun Shen, Yangri Duan, Hangbin Jin\",\"doi\":\"10.1177/17562848251357067\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Several observational studies suggest a potential association between cholecystectomy and the risk of developing microscopic colitis (MC). 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引用次数: 0
摘要
背景：几项观察性研究表明胆囊切除术与发生显微结肠炎（MC）的风险之间存在潜在关联。然而，目前的研究结果仍然不一致。目的：为了解决这一差异，我们进行了一项系统综述和荟萃分析，以全面评估胆囊切除术与mc风险之间的关系。数据来源和方法：对PubMed、Embase和Web of Science进行系统搜索，以确定评估胆囊切除术与MC风险之间关系的研究。如果研究报告了效果估计或提供了足够的计算数据，则该研究是合格的。两位独立作者提取了数据并评估了纳入研究的质量。随机效应模型用于汇集优势比（or），并根据患者特征和研究质量进行亚组分析。结果：6项观察性研究被纳入最终分析。合并OR为0.80(95%可信区间：0.52-1.22)，敏感性分析证实了结果的稳健性，表明胆囊切除术与MC风险无显著相关性。基于地理位置、研究设计、研究质量、胆囊切除术数据收集方法、对照人群和MC亚型的亚组分析一致显示无显著相关性。结论：目前的证据表明胆囊切除术与MC风险之间没有统计学上显著的关联。未来的研究应包括不同地理和种族背景的人群，利用医疗记录获得准确的手术史，并考虑潜在的混杂因素。为了获得更可靠和明确的结论，大规模的前瞻性研究将是必不可少的。试用普洛斯普洛斯注册：CRD42024592056。
Cholecystectomy and the risk of microscopic colitis: a systematic review and meta-analysis.
Background: Several observational studies suggest a potential association between cholecystectomy and the risk of developing microscopic colitis (MC). However, the current findings remain inconsistent.
Objectives: To address this discrepancy, we conducted a systematic review and meta-analysis to comprehensively assess the association between cholecystectomy and the risk of MC.
Design: Systematic review and meta-analysis.
Data sources and methods: A systematic search of PubMed, Embase, and Web of Science was conducted to identify studies evaluating the association between cholecystectomy and MC risk. Studies were eligible if they reported effect estimates or provided sufficient data for calculation. Two independent authors extracted the data and assessed the quality of included studies. A random-effects model was used to pool odds ratios (ORs), with subgroup analyses performed according to patient characteristics and study quality.
Results: Six observational studies were included in the final analysis. The pooled OR was 0.80 (95% confidence interval: 0.52-1.22), and sensitivity analysis confirmed the robustness of the results, indicating no significant association between cholecystectomy and MC risk. Subgroup analyses based on geographic location, study design, study quality, methods of cholecystectomy data collection, control populations, and MC subtypes consistently showed no significant association.
Conclusion: Current evidence suggests no statistically significant association between cholecystectomy and the risk of MC. Future research should include populations with diverse geographic and ethnic backgrounds, utilize medical records for accurate surgical history, and account for potential confounding factors. Large-scale prospective studies will be essential to obtain more reliable and definitive conclusions.
期刊介绍：
Therapeutic Advances in Gastroenterology is an open access journal which delivers the highest quality peer-reviewed original research articles, reviews, and scholarly comment on pioneering efforts and innovative studies in the medical treatment of gastrointestinal and hepatic disorders. The journal has a strong clinical and pharmacological focus and is aimed at an international audience of clinicians and researchers in gastroenterology and related disciplines, providing an online forum for rapid dissemination of recent research and perspectives in this area.
The editors welcome original research articles across all areas of gastroenterology and hepatology.
The journal publishes original research articles and review articles primarily. Original research manuscripts may include laboratory, animal or human/clinical studies – all phases. Letters to the Editor and Case Reports will also be considered.
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