Seokjun Kim, Yejun Son, Jiyeon Oh, Soeun Kim, Wonwoo Jang, Sooji Lee, Lee Smith, Damiano Pizzol, Jinseok Lee, Hayeon Lee, Christa J Nehs, Matthew A Nehs, Junyang Jung, Jiseung Kang, Dong Keon Yon
{"title":"185个国家脑和中枢神经系统癌症的全球负担，以及到2050年的预测：基于人群的GLOBOCAN 2022系统分析","authors":"Seokjun Kim, Yejun Son, Jiyeon Oh, Soeun Kim, Wonwoo Jang, Sooji Lee, Lee Smith, Damiano Pizzol, Jinseok Lee, Hayeon Lee, Christa J Nehs, Matthew A Nehs, Junyang Jung, Jiseung Kang, Dong Keon Yon","doi":"10.1007/s11060-025-05164-0","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Brain and central nervous system (CNS) cancers are associated with high mortality and morbidity. Here, we aimed to systematically evaluate and compare brain and CNS cancer between pediatric and adult populations.</p><p><strong>Methods: </strong>This study utilized the GLOBOCAN 2022 database to analyze incidence and mortality estimates for brain and CNS cancers across 185 countries and territories in 2022. Joinpoint regression was employed to estimate the average annual percent change in age-standardized incidence rates (ASIR) and age-standardized mortality rates (ASMR).</p><p><strong>Results: </strong>In 2022, the global estimated ASIR of brain and CNS cancers was 3.5 per 100,000 people, with 321,624 new cases. An estimated 248,403 deaths were attributed to brain and CNS cancer, with an ASMR of 2.6 per 100,000 people. In 2022, pediatric brain and CNS cancers in individuals aged 0-14 years ranked second globally for both incidence and mortality across various cancer subtypes, while for individuals aged ≥ 15 years, they ranked 19th and 12th, respectively. Globally, the mortality-to-incidence ratios of brain and CNS cancer were 47.7% in pediatrics aged 0-14 years and 77.8% in individuals aged ≥ 15 years, respectively. By 2050, if current trends persist, brain and CNS cancer among individuals aged 0-14 years is projected to decrease by 9.2% globally, but this trend is limited to countries with higher Human Development Index (HDI). Among individuals aged ≥ 15 years, if incidence rates remain constant, global estimated cases of brain and CNS cancer are projected to increase by 32.9% by 2050 and all HDI subgroups are predicted to experience an upward trend in incidence, with the magnitude of increase being more significant in lower HDI up to 2050.</p><p><strong>Conclusion: </strong>This study identified substantial geographical and socioeconomic inequalities in the brain and CNS cancers globally, with potential underreporting concerns in pediatric cases and increasing burdens predicted up to 2050, particularly in lower HDI countries.</p>","PeriodicalId":16425,"journal":{"name":"Journal of Neuro-Oncology","volume":" ","pages":"673-685"},"PeriodicalIF":3.1000,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Global burden of brain and central nervous system cancer in 185 countries, and projections up to 2050: a population-based systematic analysis of GLOBOCAN 2022.\",\"authors\":\"Seokjun Kim, Yejun Son, Jiyeon Oh, Soeun Kim, Wonwoo Jang, Sooji Lee, Lee Smith, Damiano Pizzol, Jinseok Lee, Hayeon Lee, Christa J Nehs, Matthew A Nehs, Junyang Jung, Jiseung Kang, Dong Keon Yon\",\"doi\":\"10.1007/s11060-025-05164-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Brain and central nervous system (CNS) cancers are associated with high mortality and morbidity. Here, we aimed to systematically evaluate and compare brain and CNS cancer between pediatric and adult populations.</p><p><strong>Methods: </strong>This study utilized the GLOBOCAN 2022 database to analyze incidence and mortality estimates for brain and CNS cancers across 185 countries and territories in 2022. Joinpoint regression was employed to estimate the average annual percent change in age-standardized incidence rates (ASIR) and age-standardized mortality rates (ASMR).</p><p><strong>Results: </strong>In 2022, the global estimated ASIR of brain and CNS cancers was 3.5 per 100,000 people, with 321,624 new cases. An estimated 248,403 deaths were attributed to brain and CNS cancer, with an ASMR of 2.6 per 100,000 people. In 2022, pediatric brain and CNS cancers in individuals aged 0-14 years ranked second globally for both incidence and mortality across various cancer subtypes, while for individuals aged ≥ 15 years, they ranked 19th and 12th, respectively. Globally, the mortality-to-incidence ratios of brain and CNS cancer were 47.7% in pediatrics aged 0-14 years and 77.8% in individuals aged ≥ 15 years, respectively. By 2050, if current trends persist, brain and CNS cancer among individuals aged 0-14 years is projected to decrease by 9.2% globally, but this trend is limited to countries with higher Human Development Index (HDI). Among individuals aged ≥ 15 years, if incidence rates remain constant, global estimated cases of brain and CNS cancer are projected to increase by 32.9% by 2050 and all HDI subgroups are predicted to experience an upward trend in incidence, with the magnitude of increase being more significant in lower HDI up to 2050.</p><p><strong>Conclusion: </strong>This study identified substantial geographical and socioeconomic inequalities in the brain and CNS cancers globally, with potential underreporting concerns in pediatric cases and increasing burdens predicted up to 2050, particularly in lower HDI countries.</p>\",\"PeriodicalId\":16425,\"journal\":{\"name\":\"Journal of Neuro-Oncology\",\"volume\":\" \",\"pages\":\"673-685\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2025-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Neuro-Oncology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s11060-025-05164-0\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/7/28 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Neuro-Oncology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s11060-025-05164-0","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/28 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Global burden of brain and central nervous system cancer in 185 countries, and projections up to 2050: a population-based systematic analysis of GLOBOCAN 2022.
Background: Brain and central nervous system (CNS) cancers are associated with high mortality and morbidity. Here, we aimed to systematically evaluate and compare brain and CNS cancer between pediatric and adult populations.
Methods: This study utilized the GLOBOCAN 2022 database to analyze incidence and mortality estimates for brain and CNS cancers across 185 countries and territories in 2022. Joinpoint regression was employed to estimate the average annual percent change in age-standardized incidence rates (ASIR) and age-standardized mortality rates (ASMR).
Results: In 2022, the global estimated ASIR of brain and CNS cancers was 3.5 per 100,000 people, with 321,624 new cases. An estimated 248,403 deaths were attributed to brain and CNS cancer, with an ASMR of 2.6 per 100,000 people. In 2022, pediatric brain and CNS cancers in individuals aged 0-14 years ranked second globally for both incidence and mortality across various cancer subtypes, while for individuals aged ≥ 15 years, they ranked 19th and 12th, respectively. Globally, the mortality-to-incidence ratios of brain and CNS cancer were 47.7% in pediatrics aged 0-14 years and 77.8% in individuals aged ≥ 15 years, respectively. By 2050, if current trends persist, brain and CNS cancer among individuals aged 0-14 years is projected to decrease by 9.2% globally, but this trend is limited to countries with higher Human Development Index (HDI). Among individuals aged ≥ 15 years, if incidence rates remain constant, global estimated cases of brain and CNS cancer are projected to increase by 32.9% by 2050 and all HDI subgroups are predicted to experience an upward trend in incidence, with the magnitude of increase being more significant in lower HDI up to 2050.
Conclusion: This study identified substantial geographical and socioeconomic inequalities in the brain and CNS cancers globally, with potential underreporting concerns in pediatric cases and increasing burdens predicted up to 2050, particularly in lower HDI countries.
期刊介绍：
The Journal of Neuro-Oncology is a multi-disciplinary journal encompassing basic, applied, and clinical investigations in all research areas as they relate to cancer and the central nervous system. It provides a single forum for communication among neurologists, neurosurgeons, radiotherapists, medical oncologists, neuropathologists, neurodiagnosticians, and laboratory-based oncologists conducting relevant research. The Journal of Neuro-Oncology does not seek to isolate the field, but rather to focus the efforts of many disciplines in one publication through a format which pulls together these diverse interests. More than any other field of oncology, cancer of the central nervous system requires multi-disciplinary approaches. To alleviate having to scan dozens of journals of cell biology, pathology, laboratory and clinical endeavours, JNO is a periodical in which current, high-quality, relevant research in all aspects of neuro-oncology may be found.
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